Tongling SHAN
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: Basic and Applied Research on viral metagenomic and Coronaviruses
1. Introduction
Our research focuses on animal virus spectrum, the etiology of PEDV and the mechanism of the interactive game between the virus and the host. ① Depicted the virus spectrum of animal species, and found novel viruses; ② the molecular mechanisms of host antiviral proteins inhibiting the proliferation of virus; ③ the new mechanism of virus antagonizing host. In the past five years, I have published 40 SCI papers in Microbiome (1), Autophagy (3), Journal of Virology (7), Journal of Biological Chemistry (2). Headed the national key research and development program, the youth science and technology award of the Chinese academy of agriculture, and the vice president of the national innovation alliance for wildlife biosafety control.
2. Contact Information
Email: shantongling@shvri.ac.cn
Tel: 13671979543
Address: 518 Ziyue Road, Minhang District, Shanghai, 200241, China
3. Selected Publications
(*corresponding author，#co-first author)
(1). Xueying Zhai*, Ning Kong*, Yu Zhang*, Yiyi Song*, Wenzhen Qin* , Xinyu Yang, Chenqian Ye, Manqing Ye, Wu Tong, Changlong Liu, Hao Zheng, Hai Yu, Wen Zhang, Xia Yang, Gaiping Zhang #, Guangzhi Tong #, Tongling Shan #. N protein of PEDV plays chess game with host proteins by selective autophagy. Autophagy. 2023;1-15. doi: 10.1080/15548627.2023.2181615. Online ahead of print.
(2). Tongling Shan *, Shixing Yang * , Haoning Wang *, Hao Wang* , Ju Zhang , Ga Gong, Yuqing Xiao, Jie Yang, Xiaolong Wang, Juan Lu, Min Zhao, Zijun Yang, Xiang Lu, Ziyuan Dai， Yumin He, Xu Chen, Rui Zhou, Yuxin Yao, Ning Kong, Jian Zeng, Xiaochun Wang, Quan Shen, Xutao Deng, Jianmin Zhang, Eric Delwart , Guangzhi Tong #, Wen Zhang#.Virome in cloaca of wild and breeding birds revealed diversity of significant viruses. Microbiome. 2022. 12;10(1):60. doi: 10.1186/s40168-022-01246-7.
(3). Dage Sun*, Ning Kong*, Sujie Dong *, Xiaoyong Chen, Wenzhen Qin, Hua Wang, Yajuan Jiao, Huanjie Zhai, Liwei Li, Fei Gao, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong # and Tongling Shan #.2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8. Autophagy. 2022;18(8):1969-1981. doi: 10.1080/15548627.2021.2015740..
(4). Ning Kong*, Tongling Shan*, Hua Wang, Yajuan Jiao , Yewen Zuo , Liwei Li, Wu Tong, Lingxue Yu, Yifeng Jiang , Yanjun Zhou , Guoxin Li, Fei Gao, Hai Yu , Hao Zheng , Guangzhi Tong#. BST2 Suppresses Porcine Epidemic Diarrhea Virus Replication by Targeting and Degrading Virus Nucleocapsid Protein With Selective Autophagy. Autophagy. 2020;16(10):1737-1752. doi: 10.1080/15548627.2019.1707487
(5). Min Zhao*, Chanjuan Yue*, Zijun Yang, Yunli Li, Dongsheng Zhang, Ju Zhang, Shixing Yang, Quan Shen, Xiaoyan Su, Dunwu Qi, Rui Ma, Yuqing Xiao, Rong Hou, Xia Yan, Lin Li, Yanshan Zhou, Jiabin Liu, Xiaochun Wang, Wei Wu, Wen Zhang#, Tongling Shan#, Songrui Liu#.Viral metagenomics unveiled extensive communications of viruses within giant pandas and their associated organisms in the same ecosystem. Science of the Total Environment. 2022 Jan 20;153317. doi: 10.1016/j.scitotenv.2022.153317. Online ahead of print.
(6). Xiaoquan Wang*, Wu Tong *, Xinyu Yang*, Huanjie Zhai*, Wenzhen Qin, Changlong Liu, Hao Zheng, Hai Yu, Guangzhi Tong Zhendong Zhang#, Ning Kong#, Tongling Shan #. RBM14 inhibits PEDV replication by recruiting P62 to degrade nuclear coat protein N through the autophagy pathway and promoting IFN expression. Journal of Virology, 2024
(7). Xinyu Yang*, Ning Kong*, Wenzhen Qin*, Xueying Zhai, Yiyi Song, Wu Tong, Changlong Liu, Hao Zheng, Hai Yu, Wen Zhang#, Guangzhi Tong#, and Tongling Shan#. PGAM5 Degrades PDCoV N Protein and Activates Type-I Interferon to Antagonize Viral Replication. Journal of Virology, 2023 Oct 26:e0147023. doi: 10.1128/jvi.01470-23.
(8). Wenzhen Qina, b*, Ning Konga *, Chunmei Wang a *, Sujie Donga, Huanjie Zhaia, Xueying Zhaia, Xinyu Yanga, Chenqian Yea, Manqing Yea, Wu Tonga, Changlong Liua, Lingxue Yua, Hao Zhenga, Hai Yua, Daoliang Lanb, Wen Zhangc#, Guangzhi Tonga#, Tongling Shana#. hnRNP K degrades viral nucleocapsid protein and induces type I IFN production to inhibit porcine epidemic diarrhea virus replication. Journal of Virology. 2022 Nov 1:e0155522. doi: 10.1128/jvi.01555-22. Online ahead of print.
(9). Wenzhen Qina, b*, Ning Konga *, Yu Zhangc*, Chunmei Wang a *, Sujie Donga, Huanjie Zhaia, Xueying Zhaia, Xinyu Yanga, Chenqian Yea, Manqing Yea, Wu Tonga, Changlong Liua, Lingxue Yua, Hao Zhenga, Hai Yua, Wen Zhangd, Daoliang Lanb, Guangzhi Tonga#, Tongling Shana#. PTBP1 suppresses porcine epidemic diarrhea virus replication via inducing protein degradation and IFN production. Journal of Biological Chemistry. 2023 Jun 29;299(8):104987. doi: 10.1016/j.jbc.2023.104987.
(10). Xueying Zhaia, b*, Ning Kongb *, Chunmei Wang b *, Wenzhen Qinb, Sujie Dongb, Huanjie Zhaib, Xinyu Yangb, Chenqian Yeb, Manqing Yeb, Guoxin Lib, Wu Tongb, Changlong Liub, Hao Zhengb, Hai Yub, Wen Zhangc, Xia Yang a#, Guangzhi Tongb#, Tongling Shanb#. PRPF19 limits porcine epidemic diarrhea virus replication through targeting and degrading viral capsid protein. Journal of Virology. 2023 Jan 31;97(1):e0161422. doi: 10.1128/jvi.01614-22
(11). Sujie Dong *, Ning Kong *, Chunmei Wang*,Youwen Li, Dage Sun, Wenzhen Qin, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong #, Tongling Shan #.FUBP3 degrades the PEDV nucleocapsid protein and induces the production of type I interferon. Journal of Virology. 2022 Jul 13;96(13):e0061822. doi: 10.1128/jvi.00618-22. Epub 2022 Jun 13
(12). Wenzhen Qin*, Ning Kong *, Yu Zhang*, Sujie Dong, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Hai Yu, Wen Zhang, Guangzhi Tong, Daoliang Lan#, Wu Tong#, Tongling Shan#. Nuclear ribonucleoprotein RALY targets virus nucleocapsid protein and induces autophagy to restrict porcine epidemic diarrhea virus replication. Journal of Biological Chemistry. 2022 Aug;298(8):102190. doi: 10.1016/j.jbc.2022.102190. Epub 2022 Jun 24.
(13). Sujie Dong *, Ning Kong *, Yu Zhang*, Youwen Li*, Dage Sun, Wenzhen Qin, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong #, Tongling Shan #.TARDBP inhibits porcine epidemic diarrhea virus replication by degrading viral nucleocapsid protein and activating type I IFN signaling. Journal of Virology. 2022 May 25;96(10):e0007022. doi: 10.1128/jvi.00070-22. Epub 2022 May 2
(14). Hua Wang*, Ning Kong*, Yajuan Jiao*, Sujie Dong*, Dage Sun, Xiaoyong Chen, Hao Zheng, Wu Tong, Hai Yu, Lingxue Yu, Wen Zhang, Guangzhi Tong#, Tongling Shan#.EGR1 suppresses porcine epidemic diarrhea virus replication by regulating IRAV to degrade viral nucleocapsid protein. Journal of Virology. 2021 Jul 21:JVI0064521. doi: 10.1128/JVI.00645-21. Epub ahead of print. PMID: 34287043.
(15). Zijun Yang*, Hao Wang*, Shixing Yang, Xiaochun Wang, Quan Shen, Likai Ji, Jian Zeng, Wen Zhang#, Haiyan Gong#, Tongling Shan#. Virome diversity of ticks feeding on domestic mammals in China. Virologica sinica. 2023 11;S1995-820X(23)00009-3. doi: 10.1016/j.virs.2023.02.001. Online ahead of print.
(16). Ziyuan Dai*, Haoning Wang*, Haisheng Wu*, Qing Zhang, Likai Ji, Xiaochun Wang, Quan Shen, Shixing Yang, Xiao Ma, Tongling Shan#, Wen Zhang#. Parvovirus dark matter in the cloaca of wild birds. Gigascience. 2023;12:giad001. doi: 10.1093/gigascience/giad001.
(17). Min Zhao*,, Siwen Bao*,, Diandian Xu, Jingxian He , Han Zhang , Likai Ji, Shixing Yang, Xiaochun Wang, Quan Shen, Jia Liu, Qing Zhang, Xiao Ma#, Wen Zhang #, Tongling Shan #. Virome of wild rats (Rattus norvegicus) captured far from pig farms in Jiangsu province of China reveals novel porcine circovirus type 2d (PCV2d) sequences. Virology Journal. 2023 Mar 9;20(1):46. doi: 10.1186/s12985-023-02005-2
(18). Yajuan Jiao*, Ning Kong*, Hua Wang*, Dage Sun*, Sujie Dong, Xiaoyong Chen, Hao Zheng, Wu Tong, Hai Yu, Lingxue Yu, Yaowei Huang, Huan Wang, Baokun Sui, Ling Zhao, Ying Liao, Wen Zhang, Guangzhi Tong #, Tongling Shan#.PABPC4 broadly inhibits coronavirus replication by degrading nucleocapsid protein through selective autophagy. Microbiology Spectrum. 2021, 6: e0090821. doi: 10.1128/Spectrum.00908-21.
(19). Yuan Xi*, Xiaojie Jiang*, Xinrui Xie*, Min Zhao, Han Zhang, Kailin Qin, Xiaochun Wang, Yuwei Liu, Shixing Yang, Quan Shen , Likai Ji , Peng Shang# , Wen Zhang# , Tongling Shan#. Viromics Reveals the High Diversity of Viruses from Fishes of the Tibet Highland. Microbiology Spectrum. 2023 Jun 15;11(3):e0094623. doi: 10.1128/spectrum.00946-23
(20). Huanjie Zhai, Wenzhen Qin, Sujie Dong, Xinyu Yang, Xueying Zhai, Wu Tong, Changlong Liu, Hao Zheng, Hai Yu , Ning Kong, Guangzhi Tong, Tongling Shan. PEDV N protein capture protein translation element PABPC1 and eIF4F to promote viral replication. Veterinary Microbiology. 2023 Aug 9;284:109844. doi: 10.1016/j.vetmic.2023.109844.