Dr. Yanjun Zhou, Professor, PhD

Research direction: immune and pathogenic mechanism of Porcine Reproductive and Respiratory Syndrome Virus, Porcine Epidemic Diarrhea Virus and development of new genetic engineering vaccine.

1. Resume

Dr. Yanjun Zhou, Ph.D., research professor, doctoral supervisor, chief scientist of the research team for prevention and control of porcine viral reproductive disorders and diseases. She was included in the training plan of Shanghai leading talent reserve team in 2011.

She mainly engaged in the immune and pathogenic mechanism of Porcine Reproductive and Respiratory Syndrome Virus, Porcine Epidemic Diarrhea Virus and the development of new genetic engineering vaccines. She has presided over more than ten national, provincial and ministerial scientific research projects, including National Natural Science Foundation projects, National Key R&D Programs and National "863" Programs. She participated in more than 20 research projects, such as the National "973" Plan Project and the National Modern Agricultural Industrial Technology Pig System Project. The scientific research achievements of Dr. Yanjun Zhou won 2 second prizes of national scientific and technological progress award and 7 provincial and ministerial-level scientific and technological awards. She had obtained 1 new veterinary drug registration certificate and 1 agricultural genetically modified safety certificate, and her 12 national invention patents were authorized. For article publication, she had published more than 100 articles in professional academic journals, including more than 40 articles in SCI journals. For student training, she had trained more than 20 doctoral and master students.

2. Contact information

Telephone number: 021-34293135

Email Address: yjzhou@shvri.ac.cn

3. Representative articles

(1). Chen P, Zhu J, Yu J, Liu R, Lao M, Yu L, Gao F, Jiang Y, Liu C, Tong W, Liu H, Tong G*, Zhou Y*. Porcine epidemic diarrhea virus strain FJzz1 infection induces type I/III IFNs production through RLRs and TLRs-mediated signaling. Front Immunol. 2022 Jul 25;13:984448.

(2). Li L, Qiao S, Li G, Tong W, Dong S, Liu J, Guo Z, Zheng H, Zhao R, Tong G, Zhou Y*, Gao F*. The Indirect ELISA and Monoclonal Antibody against African Swine Fever Virus p17 Revealed Efficient Detection and Application Prospects. Viruses. 2022 Dec 23;15(1):50.

(3). Chen P, Tan X, Lao M, Wu X, Zhao X, Zhou S, Yu J, Zhu J, Yu L, Tong W, Gao F, Yu H, Liu C, Jiang Y, Tong G*, Zhou Y*. The Novel PRRSV Strain HBap4-2018 with a Unique Recombinant Pattern Is Highly Pathogenic to Piglets. Virol Sin. 2021 , 36(6): 1611-1625.

(4). Jiang Y, Tong W, Yu L, Li L, Gao F, Li G, Liu C, Chen P, Shen Q, Zhang Y, Zhou Y*, Tong G*. Identification of Virulence Associated Region during Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus during Attenuation In Vitro: Complex Question with Different Strain Backgrounds. Viruses. 2021 , 14(1):40.

(5). Jiang Y, Li X, Yu L, Tong W, Chen P, Wang S, Zhao K, Tan X, Gao F, Yu H, Li G, Li L, Zhang Y, van den Born E, Zhou Y*, Tong G*. Immune efficacy of a candidate porcine reproductive and respiratory syndrome vaccine rHN-NP49 administered by a Needle-free intradermal delivery system in comparison with intramuscular injection. Vaccine. 2021 , 39(39):5557-5562.

(6). Chen P, Zhao X, Zhou S, Zhou T, Tan X, Wu X, Tong W, Gao F, Yu L, Jiang Y, Yu H, Yang Z, Tong G*, Zhou Y*. A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro. Virol Sin. 2021 , 36(5):1052-1065.

(7). Yu L, Wang X, Yu H, Jiang Y, Gao F, Tong W, Li L, Li H, Yang S, Chen P, Yang D, Zhang W, Tong G*, Zhou Y*. The emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus with additional 120aa deletion in Nsp2 region in Jiangxi, China. Transbound Emerg Dis. 2018, 65(6):1740-1748.

(8). Chen P, Wang K, Hou Y, Li H, Li X, Yu L, Jiang Y, Gao F, Tong W, Yu H, Yang Z, Tong G*, Zhou Y*. Genetic evolution analysis and pathogenicity assessment of porcine epidemic diarrhea virus strains circulating in part of China during 2011-2017. Infect Genet Evol. 2019, 69:153-165.

(9). Wang K, Xie C, Zhang J, Zhang W, Yang D, Yu L, Jiang Y, Yang S, Gao F, Yang Z, Zhou Y*, Tong G*. The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea Virus. Sci Rep. 2016 Dec 19;6:39010.

(10). Zhou Y, Wu Y, Zhu J, Tong W, Yu H, Jiang Y, Tong G*. Complete genome sequence of a virulent porcine epidemic diarrhea virus strain. J Virol. 2012 Dec;86(24):13862.

4. Representative patents

(1). Porcine Epidemic Diarrhea Virus vaccine and its preparation method, national invention patent, 202110187738.3.

(2). Monoclonal antibody of Porcine Delta Coronavirus N protein, epitope and application thereof, national invention patent, ZL201711127879.6.

(3). Attenuated vaccine strain marked by genetic engineering of Porcine Reproductive and Respiratory Syndrome Virus and application thereof, national invention patent, ZL201110146821.2.

(4). ELISA differential diagnosis kit for PRRSV gene-labeled vaccine strain, method and application thereof, national invention patent, ZL201310240060.6.

(5). ELISA differential diagnosis kit for PRRSV gene-labeled vaccine strain, method and application thereof, national invention patent, ZL201310217805.7.

(6). RT-PCR differential diagnosis kit for Porcine Epidemic Diarrhea Virus and its application, national invention patent, ZL201310217682.7.

(7). Infectious clone vaccine strain of Porcine Reproductive and Respiratory Syndrome Virus and application thereof, national invention patent, ZL201010559005.X.

(8). Recombinant PRRSV attenuated vaccine strain expressing GM-CSF, preparation method and application thereof, national invention patent, ZL201410056557.7.

(9). Construction method and application of PRRSV recombinant plasmid expressing luciferase gene of Renila or Firefly, national invention patent, ZL201510069182.2

(10). Virulent strain of Porcine Reproductive and Respiratory Syndrome Virus, attenuated vaccine strain thereof and application thereof, national invention patent，ZL200810097546.8.

5. Rewards

(1). Heilongjiang Province Patent Gold Award: the virulent strain of Porcine Reproductive and Respiratory Syndrome Virus, its attenuated vaccine strain and its application, ranked third, certificate number: 2022-03, 2022.

(2). Second prize of technological invention in Heilongjiang Province: research and application of prevention and control technology of highly pathogenic porcine blue ear disease, ranking third, certificate number: 2013-144-03, 2013.

(3). The first prize of scientific and technological achievements of China Academy of Agricultural Sciences: isolation and identification of highly pathogenic Porcine Reproductive and Respiratory Syndrome pathogen and development and application of attenuated vaccine, ranked third with certificate number: 2012-1-06-R03, 2012.

(4). China Agricultural Science and Technology Award-Excellent Innovation Team Award (equivalent to the first prize of scientific research achievements): innovative team for prevention and control of Porcine Reproductive and Respiratory Syndrome, ranked fifth, certificate number: TD2015-R-009-05, 2015.

(5). Second prize of national scientific and technological progress: prevention and control technology and application of Porcine Reproductive and Respiratory Syndrome, ranked eighth, certificate number: 2010-J-203-2-07-R08, 2010.