Jinlin ZHOU

Ph. D, M.V.M，Head of Division of Animal parasitology

Chief-scientist，Professor

E-mail: jinlinzhou@shvri.ac.cn

Tel: 021-34293138 (O)

Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;

1. Education

2000-2002 Postdoctoral, Department of Veterinary Medicine, Hokkaido University, Sapporo, Japan.

1995-1998 PhD, Veterinary Parasitology, Graduate School of Chinese Academy of Agricultural Sciences, Beijing, China.

1989-1992 MS degree, Veterinary Parasitology, Nanjing Agricultural University, Nanjing, China.

1985-1989 BSc degree, Veterinary Medicine, Anhui Agriculture University, Hefei, China

2. Professional Experience

2007.1-present, Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

2006.9-2006.12, Associate Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China

2004.4-2006.8, Visit Scientist, National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Japan

2002.10-2004.3, Associate Professor, Shanghai Institute of Animal parasitology, Chinese Academy of Agricultural Sciences. Shanghai, China

3. Current Research Topics

Development of the dsRNA anti-tick agent

Epidemiology of emerging and re-emerging protozoan diseases in China

The relationship between ticks and tick-borne protozoan

4. Publications

(1). Mohsin N, Malik I, Zhang H, Hassan IA, Cao J, Zhou Y, Hameed M, Kuthu ZH, Zhou J. Proteomic Analysis of Exosome-Like Vesicles Isolated From Saliva of the Tick Haemaphysalis longicornis, Frontiers in Cellular and Infection Microbiology, 2020.10: 10:3389

(2). Nawaz M, Malik I, Hameed M, Hussain Kuthu Z, Zhou J. Modifications of histones in parasites as drug targets. Vet Parasitol. 2020 Feb;278:109029. doi: 10.1016/j.vetpar.2020.109029.

(3). Xu Z, Yan Y, Zhang H, Cao J, Zhou Y, Xu Q, Zhou J. A serpin from the tick Rhipicephalus haemaphysaloides: Involvement in vitellogenesis. Vet Parasitol. 2020 Mar;279:109064. doi: 10.1016/j.vetpar.2020.109064.

(4). Hassan IA, Wang Y, Zhou Y, Cao J, Zhang H, Zhou J. Cross protection induced by combined Subolesin-based DNA and protein immunizations against adult Haemaphysalis longicornis. Vaccine. 2020 Jan 22;38(4):907-915. doi: 10.1016/j.vaccine.2019.10.076.

(5). Wei N, Lu J, Gong H, Xu Z, Zhang H, Cui L, Zhou J, Lin Z. Inclusion of PD-L1 into a recombinant profilin antigen enhances immunity against Babesia microti in a murine model. Ticks Tick Borne Dis. 2020 Jul;11(4):101446. doi: 10.1016/j.ttbdis.2020.101446.

(6). Wang F, Wang Y, Wang G, Zhang H, Kuang C, Zhou Y, Cao J, Zhou J. Ovary Proteome Analysis Reveals RH36 Regulates Reproduction via Vitellin Uptake Mediated by HSP70 Protein in Hard Ticks. Frontiers in Cellular and Infection Microbiology 2020 Mar 10;10:93. doi: 10.3389/fcimb.2020.00093.

(7). Kuang C, Wang F, Zhou Y, Cao J, Zhang H, Gong H, Zhou R, Zhou J. Molecular characterization of clathrin heavy chain (Chc) in Rhipicephalus haemaphysaloides and its effect on vitellogenin (Vg) expression via the clathrin-mediated endocytic pathway. Exp Appl Acarol. 2020 Jan;80(1):71-89. doi: 10.1007/s10493-019-00438-5.

(8). Zhang H, Wang Z, Huang J, Cao J, Zhou Y, Zhou J. A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in Babesia microti. Front Vet Sci. 2020 Feb 18;7:76. doi: 10.3389/fvets.2020.00076.

(9). Wang Y, Hu S, Tuerdi M, Yu X, Zhang H, Zhou Y, Cao J, da Silva Vaz I Jr, Zhou J. Initiator and executioner caspases in salivary gland apoptosis of Rhipicephalus haemaphysaloides. Parasit Vectors. 2020 Jun 5;13(1):288. doi: 10.1186/s13071-020-04164-5.

(10). Xu Z, Yan Y, Cao J, Zhou Y, Zhang H, Xu Q, Zhou J. A family of serine protease inhibitors (serpins) and its expression profiles in the ovaries of Rhipicephalus haemaphysaloides. Infect Genet Evol. 2020 Apr 29;84:104346. doi: 10.1016/j.meegid.2020.104346.

(11). Nawaz M, Malik MI, Hameed M, Zhou J, Research progress on the composition and function of parasite-derived exosomes. Acta Trop. 2019 Aug;196:30-36. doi: 10.1016/j.actatropica.2019.05.004

(12). Zhao Y, Huang J, Cao J, Zhou Y, Gong H, Zhang H, Zhou J. 4-NBT, a specific inhibitor of Babesia microti thioredoxin reductase, affects parasite biochemistry and proteomic properties. Ticks Tick Borne Dis. 2019 Aug;10(5):1018-1027. doi: 10.1016/j.ttbdis.2019.05.004.

(13). Xu Z, Lin Z, Wei N, Di Q, Cao J, Zhou Y, Gong H, Zhang H, Zhou J. Immunomodulatory effects of Rhipicephalus haemaphysaloides serpin RHS2 on host immune responses. Parasit Vectors. 2019 Jul 11;12(1):341. doi: 10.1186/s13071-019-3607-4.

(14). Wei N, Lin Z, Xu Z, Gong H, Zhang H, Zhou Y, Cao J, Li G, Zhou J. Immunosuppressive effects of tick protein RHcyst1  on  murine bone  marrow derived dendritic cells. Parasit Vectors. 2019,12(1):169.

(15). Wang F,  Gong H,  Zhang H,  Zhou Y,  Cao J,  Zhou J.  Molecular characterization, tissue-specific expression, and RNA knockdown of the  putative  heatshock cognate 70 protein from Rhipicephalus haemaphysaloides. Parasitol Res. 2019,118(5):1363-1370.

(16). Malik MI, Nawaz M, Hassan IA, Zhang H, Gong H, Cao J, Zhou Y, Zhou J. A microRNA profile of saliva and role of miR-375 in Haemaphysalis longicornis (Ixodida: Ixodidae). Parasit Vectors. 2019 Feb 1;12(1):68.

(17). Wei N, Lin Z, Xu Z, Cao J, Zhou Y, Zhang H, Gong H, Zhou J, Li G. A Tick Cysteine Protease Inhibitor RHcyst-1 Exhibits Antitumor Potential. Cellular Physiology and Biochemistry, 2018; 46: 2385-2400.

(18). Zhang Y, Cui J, Zhou Y, Cao J, Gong H, Zhang H, Zhou J. Liposome mediated double-stranded RNA delivery to silence ribosomal protein P0 in the tick Rhipicephalus haemaphysaloides. Ticks and Tick Borne Diseases. 2018 9(3):638-644.

(19). Huang J, Xiong K, Zhang H, Zhao Y, Cao J, Zhou Y, Gong H, Zhou J. Babesia microti thioredoxin 3 is an effective antioxidant and involved in the response to antiprotozoal drugs. Ticks and Tick Borne Diseases. 2018,9(3):645-653.

(20). Huang J, Xiong K, Zhang H, Zhao Y, Cao J, Gong H, Zhou Y, Zhou J. Molecular characterization of Babesia microti thioredoxin (BmTrx2) and its expression patterns induced by antiprotozoal drugs. Parasit and Vectors. 2018, 11(1):38.

(21). Hai X, Zhang H, Wang Z, Gong H, Cao J, Zhou Y, Zhou J. Identification of 2-Cys peroxiredoxin (BmTPx-2) as antioxidant active molecule from  Babesia microti . Frontiers in Microbiology, 2017, 8:1959.

(22). Huang Q, Cao J, Zhou Y, Huang J, Gong H, Zhang H, Zhu X, Zhou J.                                                                                                            Babesia microti aldo-keto reductase-like protein involved in antioxidant and anti-parasite response, Frontiers in Microbiology, 2017，8:2006.

(23). Wu J, Cao J, Zhou Y, Zhang H, Gong H, Zhou J. Evaluation on infectivity of  Babesia microti  to domestic animals and ticks outside the Ixodes genus. Frontiers in Microbiology, 2017，8:1915.

(24). Zhang J, Liu Q, Wang D, Li W, Beugnet F, Zhou J. Epidemiological survey of ticks and tick-borne pathogens in pet dogs in south-eastern China. Parasite. 2017，24:35.

(25). Yu X, Zhou Y, Cao J, Zhang H, Gong H, ZhouJ. Caspase-1 participates in apoptosis of salivary glands in Rhipicephalus haemaphysaloides. Parasites & Vectors,2017, 10:225.

(26). Wang F, Lu X, Guo F, Gong H, Zhang H, Zhou Y, Cao J, Zhou J. The immunomodulatory protein RH36 is relating to blood-feeding success and oviposition in hard ticks, Veterianry Parasitology. 2017,240,49-59.

(27). Zhang H, Qiao R, Gong H, Jie C, Zhou Y, Zhou J. Identification and anticoagulant activity of a novel kunitz-type protein ha11 from the salivary gland of the tick  hyalomma asiaticum . Experimental & Applied Acarology , 2017，71(1), 71-85.