Yafeng QIU
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: the mechanisms of microbial infections and host immune response
1. Introduction
EDUCATION
1997-2001 B.S., Veterinary Medicine (D.V.M. equivalent), Shandong Agricultural University, China
2001-2006 Ph.D., Preventive Veterinary Medicine, Nanjing Agricultural University, China (Supervisor: Prof. Puyan Chen)
PROFESSIONAL EXPERIENCE
2006-2009 Assistant Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), China
2009-2011 Associate Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), China
2011-2013 Postdoc Research Fellow, Division of Pulmonary&Critical Care Medicine, Department of Internal Medicine, University of Michigan
2014-present Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), China
2021-2023 Executive group leader, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), China
2024-present Group leader, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS), China
2. Contact Information
Tel: +86-21-34293635
FAX: +86-21-54081818
E-mail: yafengq@shvri.ac.cn
3. Research Interests
My research interests focus on the mechanisms of microbial infections and host immune response, mainly working on immunopathogenesis of swine respiratory diseases and zoonic diseases. The details are as follows:
Swine respiratory diseases: 1) Epidemiological characteristics of bacteria including Glaesserella parasuis , Bordetella bronchiseptica , and Streptococcus suis and so on, which contribute to Porcine Respiratory Disease Complex (PRDC); 2) Immnunopathogenesis of viral-bacterial co-infections, like PRRSV and Glaesserella parasuis co-infection; 3) Immunopathogenesis of PRRSV infection; 4) Vaccines against bacterial infections
Zoonic diseases: 1) Immunopathogenesis of Japanese encephalitis virus (JEV); 2) Replicon of JEV, which will be used as a tool for vaccine development.
4. Selected Publications
(1). Zhu, L., Wang, J.Y., Zhang, Y.B., Xiang, X., Liu, K., Wei, J.C., Li, Z.J., Shao, D.H., Li, B.B., Ma, Z.Y., and Qiu, Y.F.* (2023) A Porcine DNMT1 Variant: Molecular Cloning and Generation of Specific Polyclonal Antibody. Genes , 14(7):1324. doi: 10.3390/genes14071324.
(2). Chen, X.J#., Shi, H.Y#., Cheng, X.Y., Wang, X.X., Li, Z.J., Shao, D.H., Liu, K., Wei, J.C., Li, B.B., Wang, J., Zhou, B., Ma, Z.Y.*, and Qiu, Y.F.* (2022) Expression Analysis of Outer Membrane Protein HPS_06257 in Different Strains of Glaesserella parasuis and Its Potential Role in Protective Immune Response against HPS_06257-Expressing Strains via Antibody-Dependent Phagocytosis. Veterinary Sciences , 9(7), 342. doi:10.3390/vetsci9070342.
(3). Zhang, Y.B., Xiang, X., Lu, Y., Li, H., Wahaab, A., Sharma, M., Liu, K., Wei, J.C., Li, Z.J., Shao, D.H., Li, B.B., Ma, Z.Y.*, and Qiu, Y.F.* (2021) Downregulation of miR-296-3p by highly pathogenic porcine reproductive and respiratory syndrome virus activates the IRF1/TNF-αsignaling axis in porcine alveolar macrophages. Archives of Virology , 166(2): 511-519. DOI: 10.1007/s00705-020-04921-y.
(4). Wahaab, A., Mustafa, B.E., Hameed, M., Stevenson, N.J., Anwar, M.N., Liu, K., Wei, J.C., Qiu,Y.F.*, Ma Z.Y.* (2021) Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review. Viruses , 14(1):44. doi: 10.3390/v14010044
(5). Wahaab, A., Liu, K., Hameed, M., Anwar, M.N., Kang L., Li C.X., Ma, X.C., Wajid, A., Yang, Y., Khan, U.H., Wei, J.C., Li, B.B., Shao, D.H., Qiu, Y.F.*, Ma, Z.Y.* (2021). Identification of Cleavage Sites Proteolytically Processed by NS2B-NS3 Protease in Polyprotein of Japanese Encephalitis Virus. Pathogens , 10(2): 102. doi: 10.3390/pathogens10020102.
(6). Huang, H. #, Sharma, M. #, Zhang, Y.B., Li, C.X., Liu, K., Wei, J.C., Shao, D.H., Li, B.B., Ma, Z.Y., Cao, R.B.*, and Qiu, Y.F.* (2020). Expression Profile of Porcine TRIM26 and Its Inhibitory Effect on Interferon-β Production and Antiviral Response. Genes , 11(10): E1226. doi: 10.3390/genes11101226.
(7). Zhang, Y.B., Li, H., Xiang, X., Lu, Y., Sharma, M., Li, Z.J., Liu, K., Wei, J.C., Shao, D.H., Li, B.B., Ma, Z.Y., and Qiu, Y.F.* (2020). Identification of DNMT3B2 as the Predominant Isoform of DNMT3B in Porcine Alveolar Macrophages and Its Involvement in LPS-Stimulated TNF-a Expression. Genes , 11 (9): E1065. doi: 10.3390/genes11091065.
(8). Lu, Y.#, Zhang, Y.B.#, Sharma, M, Liu, K., Wei, J.C., Shao, D.H., Li, B.B., Tong, G.Z., Olszewski, M.A., Ma, Z.Y.*, and Qiu, Y.F.* (2020). Notch signaling contributes to the expression of inflammatory cytokines induced by highly pathogenic porcine reproductive and respiratory syndrome virus (HP-PRRSV) infection in porcine alveolar macrophages. Developmental & Comparative Immunology , 108: 103690.
(9). Xiang, X.#, Zhang, Y.B.#, Li, Q.Q., Wei, J.C., Liu, K., Shao, D.H., Li, B.B., Olszewski, M.A., Ma, Z.Y.*, and Qiu, Y.F.* (2020). Expression profile of porcine scavenger receptor A and its role in bacterial phagocytosis by macrophages. Developmental & Comparative Immunology , 104: 103534.
(10). Wang, Z.T.#, Zhang, Y.B.#, Wang, L.Y.#, Wei, J.C., Liu, K., Shao, D.H., Li, B.B., Liu, L.H., Ma, Z.Y.*, and Qiu, Y.F.* (2020). Comparative genomic analysis of Bordetella bronchiseptica isolates from the lungs of pigs with porcine respiratory disease complex (PRDC). Infection, Genetics and Evolution , 81: 104258