Zhaoguo CHEN
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: biology, invasion, pathogenic, and immune mechanisms of food-borne parasites
1. Introduction
Dr. ZHAOGUO CHEN, born in April 1970 in Yuhuan County, Zhejiang Province, P. R. China. He is a Professor, PI of SHVRI, CAAS, and the chief expert of Research Team of Animal Derived Food Safety. He is also the deputy director of the Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs, Laboratory of Quality and Safety Risk Assessment for Animal Products on Biohazards (Shanghai) of Ministry of Agriculture and Rural Affairs. His work mainly focus on the biology, invasion, pathogenic, and immune mechanisms of food-borne parasites including Cryptosporidium spp., Toxoplasma gondii , E chinococcus spp., Enterocytozoon , etc., prevention and control technologies of zoonotic parasitic diseases, and monitoring and risk assessment of animal derived food safety.
2. Education Background
2.1 Doctor's degree: Preventive Veterinary Medicine, Graduate School of Chinese Academy of Agricultural Sciences, China, from September 2008 to July 2011.
2.2 Master's degree: Preventive Veterinary Medicine, Graduate School of Chinese Academy of Agricultural Sciences, China, from September 1996 to July 1999.
2.3 Bachelor's degree: Veterinary Medicine, Department of Animal Husbandry and Veterinary Medicine, Zhejiang Agricultural University, China, from September 1988 to July 1992.
3. Employment
3.1 Research Team of Animal Derived Food Safety, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (SHVRI-CAAS); The Key Laboratory of Animal Parasitology of Ministry of Agriculture and Rural Affairs, Laboratory of Quality and Safety Risk Assessment for Animal Products on Biohazards (Shanghai) of Ministry of Agriculture and Rural Affairs.
Position: Professor, Chief Expert, and Deputy Director, from January 2016 to now.
3.2 Department of Animal Parasitology and Parasitic Diseases, Research Team of Animal Protozoiasis, SHVRI-CAAS; The Laboratory of Quality and Safety Risk Assessment for Animal Products on Biohazards (Shanghai) of Ministry of Agriculture and Rural Affairs.
Position: Professor, PI, and Deputy Director, from January 2010 to December 2015.
3.3 Department of Animal Parasitology and Parasitic Diseases, SHVRI-CAAS, from October 2004 to December 2009.
Position: Associate Professor, PI.
3.4 Laboratorio de Malaria, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Spain, from November 2003 to October 2004.
Position: Visiting Scholar.
3.5 Shanghai Animal Biotechnology Research Center, Shanghai Institute of Domestic Animal Parasitic Diseases, Chinese Academy of Agricultural Sciences; Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, from July 2000 to November 2003.
Position: Assistant Professor (July 2000 - December 2002), Associate Professor (January 2003 - November 2003), Director Assistant (July 2000 - November 2003); Visiting Scholar (July 2000 - July 2002).
3.6 Department of Poultry Parasitic Diseases (the Third Department), Shanghai Institute of Domestic Animal Parasitic Diseases, Chinese Academy of Agricultural Sciences, from July 1992 to June 2000.
Position: Researcher Assistant (July 1992-December 1997), Assistant Professor (January 1998 to June 2000), and Director Assistant (January 1998-June 2000).
4. Technical Standards
[1] Zhaoguo Chen, Rongsheng Mi, Yan Huang, Lushi Liu, Yan Wang. Nested PCR method for detection of Cryptosporidium spp. GB/T 35942-2018, National Standard, issued on February 06, 2018, and implemented on September 01, 2018.
[2] Hui Dong, Bing Huang, Hongyu Han, Zhaoguo Chen, Qiping Zhao, Shunhai Zhu. Diagnostic techniques of animal coccidiosis. GB/T18647-2020, National Standard, issued and implementation on December 14, 2020, (Replacing: Bing Huang, Zhaoguo Chen, Qi Bai. Diagnostic techniques of animal coccidiosis. GB/T18647-2002, National Standard, issued on February 19, 2002, and implemented on May 01, 2002).
[3] Zhaoguo Chen, Rongsheng Mi, Yan Huang, Haiyan Gong, Junjie Hu. Detection methods of Sarcocystis spp. in animal-derived foods. NY/T 4031-2021, Agricultural Trade Standard, issued on December 15 2021, and implemented on June 01 2022.
[4] Kehe Huang, Fu Chen, Zhaoguo Chen. Modified acid-fast staining technique for detection of Cryptosporidium spp. oocysts, NY/T 1949-2010, Agricultural Trade Standard, issued on September 21 2010, and implemented on December 01 2010.
[5] Hongjun Chen, Zhuyun SUN, Tong Sun, Zhaorong YU, Zhaoguo Chen, Jinlin Zhou, Yang Hong, Xiaofeng Wei, Yong Zhao, Chun Fan, Jianhua Hu, Guoqiang Chen, Yongjun Chen, Huili Liu. Laboratory chicken and duck - Part 2: Parasitology monitoring. DB31/T 1377.2-2022, Shanghai Regional Standard, issued on October 28 2022, and implemented February 01 2023.
5. Publications
Some of the published papers are as follows:
[1] Xiaoli Zhang1, Chenxi Wei1, Yajie Lv, Rongsheng Mi, Baoping Guo, Sajid Ur Rahman, Yehua Zhang, Long Cheng, Haiyan Jia, Yan Huang, Xiangan Han, Haiyan Gong*, Zhaoguo Chen*. EgSeverin and Eg14-3-3zeta from Echinococcus granulosus are potential antigens for serological diagnosis of echinococcosis in dogs and sheep. Microbial Pathogenesis, 2023, 179: 106110. doi: 10.1016/j.micpath.2023.106110.
[2] Long Cheng, Sajid Ur Rahman, Hai-Yan Gong, Rong-Sheng Mi, Yan Huang, Yan Zhang, Ju-Liang Qin, Cheng-Cong Yin, Min Qian* and Zhao-Guo Chen*. Transcriptome analysis of a newly established mouse model of Toxoplasma gondii pneumonia. Parasites & Vectors, 2023, 16: 59. doi: 10.1186/s13071-022-05639-3.
[3] Ying Zhang, Long Cheng, Hongyu Qiu, Tiancong Sun, Ruipeng Deng, Haiyan Gong, Rongsheng Mi, Yan Huang, Chunren Wang* and Zhaoguo Chen*. Hypothetical bromodomain-containing protein 5 is required for the growth of Toxoplasma gondii . Veterinary Parasitology, 2022, 309: 109767. doi: 10.1016/j.vetpar.2022.109767.
[4] Tiancong Sun1, Yu Chen1, Rongsheng Mi, Haiyan Gong, Shasha Zhou, Xiangan Han, Yan Huang*, Zhaoguo Chen*. Fibrillarin RNA methylase is an interacting protein of Cryptosporidium parvum calmodulin-like protein (CpCML). Microbial Pathogenesis, 2022, 170: 105679. doi: 10.1016/j.micpath.2022.105679.
[5] Yan Huang1, Yu Chen1, Yuxuan Liu, Rongsheng Mi, Xiangan Han, Haiyan Gong, Long Cheng, Zhaoguo Chen*. Isolation and identification of sporozoite membrane protein of Cryptosporidium parvum and evaluation of calmodulin-like protein immune protection. Parasite Immunology, 2022, 44(8): e12937. doi: 10.1111/pim.12937.
[6] Sajid Ur Rahman, Haiyan Gong, Rongsheng Mi, Yan Huang, Xiangan Han and Zhaoguo Chen*. Chitosan protects immunosuppressed mice against Cryptosporidium parvum infection through TLR4/STAT1 signaling pathways and gut microbiota modulation. Frontiers in Immunology, 2022, 12: 784683. doi: 10.3389/fimmu.2021.784683.
[7] Sajid UrRahman, Keke Zhou, ShaSha Zhou, Tiancong Sun, Rongsheng Mi, Yan Huang, Xiangan Han, Haiyan Gong*, Zhaoguo Chen*. Curcumin mitigates Cryptosporidium parvum infection through modulation of gut microbiota and innate immune-related genes in immunosuppressed neonatal mice. Microbial Pathogenesis, 2022, 164:105424. doi: 10.1016/j.micpath.2022.105424.
[8] Sajid Ur Rahman, Rongsheng Mi, Shasha Zhou, Haiyan Gong, Munib Ullah, Yan Huang, Xiangan Han, Zhaoguo Chen*. Advances in therapeutic and vaccine targets for Cryptosporidium : Challenges and possible mitigation strategies. Acta Tropica, 2022, 226: 106273. doi: 10.1016/j.actatropica.2021.106273.
[9] Yehua Zhang1, Jianhua Xie1, Rongsheng Mi, Hongquan Ling, Lu Luo, Haiyan Jia, Xiaoli Zhang, Yan Huang, Haiyan Gong, Xiangan Han, Zheng Zeng*, Zhaoguo Chen*. Molecular detection and genetic characterization of Toxoplasma gondii in pork from Chongqing, southwest China. Acta Tropica, 2021, 224: 106134. doi: 10.1016/j.actatropica.2021.106134.
[10] Yan Zhang, Rongsheng Mi, Lijuan Yang, Haiyan Gong, Chunzhong Xu, Yongqi Feng, Xinsheng Chen, Yan Huang, Xiangan Han and Zhaoguo Chen*. Wildlife is a potential source of human infections of Enterocytozoon bieneusi and Giardia duodenalis in Southeastern China. Frontiers in Microbiology, 2021, 12: 692837. doi: 10.3389/fmicb.2021.692837.
[11] Tao Sun1, Sajid Ur Rahman1, Jinzhong Cai, Jiangyong Zeng, Rongsheng Mi, Yehua Zhang, Haiyan Gong, Hongcai Ma, Yan Huang, Xiangan Han, Quan Zhao*, Zhaoguo Chen*. Seroprevalence and associated risk factors of Toxoplasma gondii infection in yaks ( Bos grunniens ) on the Qinghai-Tibetan Plateau of China. Parasite, 2021, 28: 43. doi: 10.1051/parasite/2021043.
[12] Jialing Yao, Zhengmao Xu, Zeyu Sun, Keke Zhou, Jinmiao Lu, Rongsheng Mi, Yan Huang, Xiangan Han, Keyi Ren, Zhaoguo Chen*, Haiyan Gong*. Response of leucine-rich repeat domain-containing protein in Haemaphysalis longicornis to Babesia microti infection and its ligand identification. Infect Immun, 2021, 89(5): e00268-20. doi: 10.1128/IAI.00268-20.
[13] Xu Wang, Haiyan Jia, Haiyan Gong, Yan Zhang, Rongsheng Mi, Yehua Zhang, Xiangan Han, Zhaoguo Chen*. Expression and functionality of allergenic genes regulated by simulated gastric juice in Anisakis pegreffii . Parasitology International, 2021, 80: 102223. doi: 10.1016/j.parint.2020.102223.
[14] Xiaoli Zhang1, Rongsheng Mi1, Yehua Zhang, Shijie Zhang, Tao Sun, Haiyan Jia, Yan Huang, Haiyan Gong, Xiangan Han, Zhaoguo Chen*. Low prevalence of spargana infection in farmed frogs in the Yangtze River Delta of China. Infection, Genetics and Evolution, 2020, 85: 104466. doi: 10.1016/j.meegid.2020.104466.
[15] Yan Zhang1, Rongsheng Mi1, Jiabing Yang, Jinxiang Wang, Haiyan Gong, Yan Huang, Xu Wang, Xiangan Han, Haining Zhou*, Zhaoguo Chen*. Enterocytozoon bieneusi genotypes in farmed goats and sheep in Ningxia, China. Infection, Genetics and Evolution, 2020, 85: 104559. doi: 10.1016/j.meegid.2020.104559.
[16] Yehua Zhang, Rongsheng Mi, Yan Huang, Luming Xia, Yushu Cai, Haiyan Jia, Xiaoli Zhang, Heng Yang, Xu Wang, Xiangan Han, Zhaoguo Chen*. Molecular detection and genetic characterization of Toxoplasma gondii in pork in Shanghai, China. Food Control, 2019, 99: 57–63. doi: 10.1016/j.actatropica.2021.106134.
[17] Heng Yang†, Rongsheng Mi†, Long Cheng, Yan Huang, Rui An, Yehua Zhang, Haiyan Jia, Xiaoli Zhang, Xu Wang, Xiangan Han and Zhaoguo Chen*. Prevalence and genetic diversity of Enterocytozoon bieneusi in sheep in China. Parasites & Vectors, 2018, 11:587. doi: 10.1186/s13071-018-3178-9.
[18] Yan Huang, Yue Song, Yanmin You, Rongsheng Mi, Xiangan Han, Haiyan Gong, Zhaoguo Chen*, Yongjie Liu*. Development of an immunocompetent mouse model susceptible to Cryptosporidium tyzzeri infection. Parasite Immunology, 2021, 43: e12800. doi: 10.1111/pim.12800.
[19] Rongsheng Mi, Xiaojuan Wang, Yan Huang, Guodong Mu, Yehua Zhang, Haiyan Jia, Xiaoli Zhang, Heng Yang, Xu Wang, Xiangan Han, Zhaoguo Chen*. Sheep as a potential source of zoonotic cryptosporidiosis in China. Applied and Environmental Microbiology, 2018, 84: e00868-18. doi: 10.1128/AEM.00868-18.
[20] Yan Huang, Wei Cao, Kai Shi, Rongsheng Mi, Ke Lu, Zhaoguo Chen*. Protective efficacy of recombinant Cryptosporidium parvum CpPRP1 sushi domain against C. tyzzeri infection in mice. Parasite Immunol. 2017, 39(9):e12449. doi: 10.1111/pim.12449.
[21] Rongsheng Mi, Xiaojiao Yang, Yan Huang, Long Cheng, Ke Lu, Xiangan Han and Zhaoguo Chen*. Immunolocation and enzyme activity analysis of Cryptosporidium parvum enolase. Parasites & Vectors, 2017, 10:273. doi: 10.1186/s13071-017-2200-y.
[22] Li-li Liu1, Zhao-guo Chen1, Rong-sheng Mi, Ke-yu Zhang, Ying-chun Liu, Wei Jiang, Chen-zhong Fei, Fei-qun Xue∗, Tao Li ∗.Effect of Acetamizuril on enolase in second-generation merozoites of Eimeria tenella . Veterinary Parasitology, 2016, 215: 88–91. doi: 10.1016/j.vetpar.2015.11.011.
[23] Zhaoguo Chen*, Rongsheng Mi, Huizhu Yu, Yaojun Shi, Yan Huang, Yongjun Chen, Peng Zhou, Youmin Cai, Jiaojiao Lin*. Prevalence of Cryptosporidium spp. in pigs in Shanghai, China. Veterinary Parasitology, 2011, 181(2-4): 113-119. doi: 10.1016/j.vetpar.2011.04.037.
6. Contact information
Tel: +86-21-34293397
E-mail: zhaoguochen@shvri.ac.cn, chenzhaoguo@caas.cn