Quan WANG
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: New high-throughput rapid detection technology for harmful substances in animal derived foods; Screening and identification of key antioxidant genes in Toxoplasma gondii and their role in natural immune evasion mechanisms; Screening diagnostic markers, vaccine candidates and drug targets for toxoplasmosis.
1. Introduction
Educationbackground
1988.09-1993.07
Undergraduate student, Nanjing Agricultural University (NAU), Degree of Veterinary Medicine, Nanjing, China.
1997.09 -2000.07
Master student, The Graduate School, Chinese Academy of Agricultural Sciences(CAAS), Degree of Preventive Veterinary Medicine, Beijing, China.
2008.09-2011.07
Ph.D. student, Nanjing Agricultural University (NAU), Degree of Veterinary Science, Nanjing, China.
Work experience
1993.09-1998.12
Research Assistant, Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China.
1999.01-2004.12
Research Associate, Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China.
2005.01 -2012.12
Associate Professor, Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China.
2013.01-now
Professor, Shanghai Veterinary Research Institute (SHVRI), Chinese Academy of Agricultural Sciences (CAAS), Shanghai, China.
2. Contact Information
Tel: +86-21-34293397
E-mail: wangquan@shvri.ac.cn
3. Research Projects
Projects Host of
(1). Natural Science Foundation of Shanghai
Name: Genome wide CRISPR / cas9 screen identifying key antioxidant genes of Toxoplasma gondii and the mechanism of these genes in natural immune escape (Project No. 22ZR1476000; 2020/04- 2025/03)
(2). Shanghai Science and Technology Promotion Agriculture Innovation Program
Name: Analysis of key risk pathways for the transmission of Toxoplasma gondii by stray cats in Shanghai and integration and demonstration of comprehensive prevention and control technologies(Project No. 2022-02-08-00-12-F01085; Sub-Project; 2022/04-2025/03)
(3). Shanghai Science and Technology Promotion Agriculture Innovation Program
Name: Research and application a detection system based on the Lanthanide microsphere test paper and the IAC sample pretreatment for precise detection of prohibited drugs and toxins in aquatic products (Project No. 2020-02-08-00-08-F01486; 2020/06 - 2024/06)
(4). Shanghai Science and Technology Commission Project
Name: Research on Quantitative detection of prohibited drugs and toxins in aquatic products using a lanthanide microsphere strip detection system based on smartphone manipulation (Project No. 19391901900; 2019/10 - 2022/09)
(5). the National Key Research and Development Programs of China
Name: Research on monitoring and early warning technologies for potential invasive livestock and poultry diseases(Project No. 2016YFD0501101; Sub-Project;2016/07 - 2020/12)
(6). Natural Science Foundation of Shanghai
Name: Effects of TR gene and three ROPs genes on virulence of Toxoplasma gondii I. (Project No. 17ZR1437300; 2017/01- 2019/12)
(7). Special Fund for Agro-scientific Research in the Public Interest
Name: Using microfluidic PCR Chip Technology for rapid detection technology research and demonstration of agricultural disease. (Project No. 201303045; 2013/01-2017/12)
(8). Shanghai science and Technology Commission technical standard Projects
Name: The research on new technical standards assay of rapid detection for nitrofuran metabolite in Animal-derived food. (Project No. 13DZ0502701; Sub-Project; 2013/07 -2016/07)
4. Selected Publications
(1). Xiaomei Wang , Chen Yang , Wei Jiang , Manyu Zhang , Ruifang Li, Yajuan Lin , Quan Wang* Rapid quantitative detection of okadaic acid in shellfish using lanthanide-labelled fluorescent-nanoparticle immunochromatographic test strips Food Control, 2023, Food Control 148:109635.
(2). Qi Liu, Wei Jiang, Yun Chen, Manyu Zhang, Xiaoling Geng and Quan Wang*.Study on Circulating Antigens in Serum of Mice With Experimental Acute Toxoplasmosis . Frontiers in Microbiology. 2021,1:612252. doi: 10.3389/fmicb.2020.612252.
(3). Yun Chen，Qi Liu， Jun-Xin Xue，Man-Yu Zhang，Xiao-Ling Geng， Quan Wang*，Wei Jiang*. Genome-Wide CRISPR/Cas9 Screen Identifies New Genes Critical for Defense Against Oxidant Stress in Toxoplasma gondii , Frontiers in Microbiology, 2021, 12: 1-13 ,doi: 10.3389/fmicb.2021.670705.
(4). Qi Liu， Wei Jiang, Yun Chen, Manyu Zhang, Xiaoling Geng and Quan Wang*.Diagnostic value of circulating antigens in the serum of piglets with experimental acute toxoplasmosis . The Journal of Immunology, 2022, 208(3): 697-706.
(5). Quan Wang, MengYao Long, CaiYun Lv, SiPei Xin, XianGan Han, Wei Jiang*. Lanthanide- labeled fluorescent-nanoparticle immunochromatographic strips enable rapid and quantitative detection of Escherichia coli O157:H7 in food samples. Food Control l. 2020,19:106894.
(6). Quan Wang, Yingchun Liu, Mingyan Wang,Yongjun Chen and Wei Jiang*. A multiplex immunochromatographic test using gold nanoparticles for the rapid and simultaneous detection of four nitrofuran metabolites in fish samples. Analytical and Bioanalytical Chemistry. 2018， 410(1): 223-233.
(7). Junxin Xue,Wei Jiang, Yongjun Chen, Fengju Gong,Minyan Wang, Peng Zeng,Can Xia,Quan Wang*,and Kehe HuangJunxin Xue,*Thioredoxin reductase from Toxoplasma gondii :an essential virulence effector with antioxidant function The FASEB Journal the FASEB Journal, 2017, 31(10): 4447-4457.
(8). Junxin Xue, Wei Jiang, Yongjun Chen, Yingchun Liu, Huajing Zhang, Yan Xiao, Yuanbiao Qiao,Kehe Huang* and Quan Wang*. Twenty-six circulating antigens and two novel diagnostic candidate molecules identified in the serum of canines with experimental acute toxoplasmosis . Parasites & Vectors (2016) 9:374.
(9). Ying-Chun Liu, Wei Jiang, Yong-Jun Chen, Yan Xiao, Jin-Lei Shi, Yuan-Biao Qiao, Hua-Jing Zhang, Tao-Li, Quan Wang*. A novel chemiluminescent ELISA for detecting furaltadone metabolite,3-amino-5-morpholinomethyl-2-oxazolidone (AMOZ) in fish, egg, honey Journal of Immunological Methods,2013,395: 36-39.
(10). Wei Jiang, Yingchun Liu, Yongjun Chen, PeterChun, Kailing Yao, Xiangan Han, Shaohui Wang,Shengqingyu,Yongjie Liu, Quan Wang*. A novel dynamic flow immunochromatographic test (DFICT) using gold nanoparticles for the serological detection of Toxoplasma gondii infection in dogs and cats. Biosensors and Bioelectronics. 2015 (72): 133–139.
5. Selected Patents and Standards
(1). A method for detecting bacteria using colloidal gold test strips containing bispecific antibodies, October 13, 2023, China, ZL 202011146123.8
(2). An efficient method and target protein for detecting acute infection of Toxoplasma gondii , June 27, 2017, China, ZL20151027187.5
(3). A method for detecting acute infection of Toxoplasma gondii and its target protein, February 8, 2017, China, ZL20151027186.2
(4). An immunomagnetic bead conjugated specific monoclonal antibodies and its preparation method for rapidly enriching Vibrio cholerae , August 9, 2022, China, ZL202110921205.3
(5). Anti Staphylococcus aureus monoclonal antibody, application, and immunomagnetic beads containing it, April 1, 2022, China, ZL202110729090.8
(6). A reagent kit, primer pair, probe, and method for detecting Vibrio parahaemolyticus , June 19, 2020, China, ZL201910281743.3
(7). A single chain antibody against influenza virus and its preparation method and application, June 4, 2014, China, ZL01210063870.4
(8). Leucomalachite green complete antigen and monoclonal antibody preparation techniques , May 20, 2009, China, ZL2005N10060994
(9). Monoclonal antibodies against GroEL protein of Riemerella anatipestifer , hybridoma cell lines and their applications, September 28, 2016, China, ZL201410088918.6
(10). A dual real-time fluorescence detection method for Vibrio parahaemolyticus and Vibrio cholerae in aquatic animals, Industry Standard for entry-exit inspection and quarantine SN/T 5125-2019.
6. Awards
Third Prize of Science and Technology Progress Award from Shanghai Municipal Science and Technology Commission, "Development and Application of New Technologies in the prevention and control testing of animal diseases and animal derived food safety ",Wang Yan; Jiang Wei; Jiang Wenming; Wang Quan; Sun Tao; Li Chunyang; Huang Zhongrong, 2017.