Hongjun CHEN

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Fields: early warning, prevention, and control of emerging and re-emerging animal viruses

1. Introduction

Professor Chen is the group’s chief scientist, head of Achievement Transformation Department, deputy editor of “Chinese Journal of animal infectious diseases”, and head of the Veterinary Drug Evaluation Center, SHVRI, CAAS.

Prof. Chen’s research focuses on emerging and re-emerging animal viruses such as African swine fever virus (ASFV), Avian influenza virus (AIV), and Fowl adenovirus (FAdV). He conducts research on molecular pathogenesis of disease-causing mechanisms, and develop rapid diagnostic techniques for early detection of these viruses. He also works on the development of immune adjuvants and novel vaccines for the prevention and control of emerging and re-emerging viruses. He has successively presided over more than 10 national and provincial projects. He has published more than 200 papers in journals including PNAS, EMI, NC, JCR and JVI. He has also obtained two clinical approvals for animal vaccines or antibodies.

2. Contact Information

E-mail: vetchj@shvri.ac.cn

3. Published Articles

(1). Liu Y, Shen Z, Xie Z, Song Y, Li Y, Liang R, Gong L, Di D, Liu J, Liu J, Chen Z, Yu W, Lv L, Zhong Q, Liao X, Tian C, Wang R, Song Q, Wang H, Peng G, Chen H. 2023. African swine fever virus I73R is a critical virulence-related gene: A potential target for attenuation. Proc Natl Acad Sci U S A 120:e2210808120.

(2). Liu Y, Xie Z, Li Y, Song Y, Di D, Liu J, Gong L, Chen Z, Wu J, Ye Z, Liu J, Yu W, Lv L, Zhong Q, Tian C, Song Q, Wang H, Chen H. 2023. Evaluation of an I177L gene-based five-gene-deleted African swine fever virus as a live attenuated vaccine in pigs. Emerg Microbes Infect 12:2148560.

(3). Huang S, Li Y, Zhang S, Chen Y, Su W, Sanchez DJ, Mai JDH, Zhi X, Chen H#, Ding X^#. 2024. A self-assembled graphene oxide adjuvant induces both enhanced humoral and cellular immune responses in influenza vaccine. J Control Release 365:716-728.

(4). Tian C, Liu Y, Di D, Xie Z, Li Y, Wang R, Li J, Liu J, Chen H. 2024. Immunogenicity and efficacy of an LNP-mRNAprepared from African Swine Fever Virus K205R. Journal of Integrative Agriculture. (Accepted)

(5). Gao H, Di D, Wu Q, Li J, Liu X, Xu Z, Xu S, Wu C, Gong L, Sun Y, Zhang G, Chen H, Wang H. 2024. Pathogenicity and horizontal transmission evaluation of a novel isolated African swine fever virus strain with a three-large-fragment-gene deletion. Vet Microbiol 290:110002.

(6). Yu W, Liu J, Liu Y, Forlenza M, Chen H. 2024. Application of CRISPR/Cas9 for Rapid Genome Editing of Pseudorabies Virus and Bovine Herpesvirus-1. Viruses 16.

(7). Duan X, Liu Y, Chen Z, Xie Z, Tian C, Li Y, Lv L, Wang R, Liu J, Chen H. 2023. Identification of monoclonal antibody targeting epitope on p72 trimeric spike of African swine fever virus. Virus Genes 59:582-590.

(8). Xie Z, Liu Y, Di D, Liu J, Gong L, Chen Z, Li Y, Yu W, Lv L, Zhong Q, Song Y, Liao X, Song Q, Wang H, Chen H. 2022. Protection Evaluation of a Five-Gene-Deleted African Swine Fever Virus Vaccine Candidate Against Homologous Challenge. Front Microbiol 13:902932.

(9). Liu Y, Li Y, Xie Z, Ao Q, Di D, Yu W, Lv L, Zhong Q, Song Y, Liao X, Song Q, Wang H, Chen H. 2021. Development and in vivo evaluation of MGF100-1R deletion mutant in an African swine fever virus Chinese strain. Vet Microbiol 261:109208.

(10). Liu J, Shi X, Lv L, Wang K, Yang Z, Li Y, Chen H. 2021. Characterization of Co-infection With Fowl Adenovirus Serotype 4 and 8a. Front Microbiol 12:771805.

(11). Liu J, Mei N, Wang Y, Shi X, Chen H. 2021. Identification of a novel immunological epitope on Hexon of fowl adenovirus serotype 4. AMB Express 11:153.

(12). Chen H, Angel M, Li W, Finch C, Gonzalez AS, Sutton T, Santos J, Perez DR. 2014. All-in-one bacmids: an efficient reverse genetics strategy for influenza A virus vaccines. J Virol 88:10013-25.