Yanjun Zhou ZHOU
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: Immune and pathogenic mechanism of Porcine Reproductive and Respiratory Syndrome Virus; Porcine Epidemic Diarrhea Virus; Development of new genetic engineering vaccine.
1. Introduction
Dr. Yanjun Zhou: Research professor; Doctoral supervisor; Chief scientist of the research team that specializes in the prevention and control of porcine viral reproductive disorders and diseases; Member of Shanghai leading talent reserve team (2011).
Dr. Yanjun Zhou has spearheaded over ten research initiatives at national, provincial, and ministerial levels, including the National Natural Science Foundation projects, National Key R&D Programs, and National “863” Programs. She has also contributed to more than 20 research projects, such as the National “973” Plan Project and the National Modern Agricultural Industrial Technology Pig System Project. Her research has been recognized with two 2nd class prize of national scientific and technological progress awards and seven provincial and ministerial-level awards. She has obtained a new veterinary drug registration certificate, an agricultural genetically modified safety certificate, and has 12 authorized national invention patents. In addition, Dr. Zhou has published over 100 articles in professional academic journals, including more than 40 in SCI journals, and has mentored over 20 doctoral and master students.
2. Contact Information
Tel: 021-34293135
E-mail: yjzhou@shvri.ac.cn
3. Representative Articles
(1). Yu J, Chen P, Liu R, Lao M, Zhu J, Zhou S, Jiang J, Huang S, Tong W, Jiang Y, Gao F, Yu L, Liu C, Yang Z, Tong G*, Zhou Y*. Newly Characterized Porcine Epidemic Diarrhea Virus GII Subtype Strain. Transboundary and Emerging Diseases, 2023, May. https://doi.org/10.1155/2023/5544724.
(2). Chen P, Zhu J, Yu J, Liu R, Lao M, Yu L, Gao F, Jiang Y, Liu C, Tong W, Liu H, Tong G*, Zhou Y*. Porcine epidemic diarrhea virus strain FJzz1 infection induces type I/III IFNs production through RLRs and TLRs-mediated signaling. Front Immunol. 2022 Jul 25;13:984448.
(3). Li L, Qiao S, Li G, Tong W, Dong S, Liu J, Guo Z, Zheng H, Zhao R, Tong G, Zhou Y*, Gao F*. The Indirect ELISA and Monoclonal Antibody against African Swine Fever Virus p17 Revealed Efficient Detection and Application Prospects. Viruses. 2022 Dec 23;15(1):50.
(4). Chen P, Tan X, Lao M, Wu X, Zhao X, Zhou S, Yu J, Zhu J, Yu L, Tong W, Gao F, Yu H, Liu C, Jiang Y, Tong G*, Zhou Y*. The Novel PRRSV Strain HBap4-2018 with a Unique Recombinant Pattern Is Highly Pathogenic to Piglets. Virol Sin. 2021 , 36(6): 1611-1625.
(5). Jiang Y, Tong W, Yu L, Li L, Gao F, Li G, Liu C, Chen P, Shen Q, Zhang Y, Zhou Y*, Tong G*. Identification of Virulence Associated Region during Highly Pathogenic Porcine Reproductive and Respiratory Syndrome Virus during Attenuation In Vitro: Complex Question with Different Strain Backgrounds. Viruses. 2021 , 14(1):40.
(6). Chen P, Zhao X, Zhou S, Zhou T, Tan X, Wu X, Tong W, Gao F, Yu L, Jiang Y, Yu H, Yang Z, Tong G*, Zhou Y*. A Virulent PEDV Strain FJzz1 with Genomic Mutations and Deletions at the High Passage Level Was Attenuated in Piglets via Serial Passage In Vitro. Virol Sin. 2021 , 36(5):1052-1065.
(7). Jiang Y, Li X, Yu L, Tong W, Chen P, Wang S, Zhao K, Tan X, Gao F, Yu H, Li G, Li L, Zhang Y, van den Born E, Zhou Y*, Tong G*. Immune efficacy of a candidate porcine reproductive and respiratory syndrome vaccine rHN-NP49 administered by a Needle-free intradermal delivery system in comparison with intramuscular injection. Vaccine. 2021 , 39(39):5557-5562.
(8). Yu L, Wang X, Yu H, Jiang Y, Gao F, Tong W, Li L, Li H, Yang S, Chen P, Yang D, Zhang W, Tong G*, Zhou Y*. The emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus with additional 120aa deletion in Nsp2 region in Jiangxi, China. Transbound Emerg Dis. 2018, 65(6):1740-1748.
(9). Chen P, Wang K, Hou Y, Li H, Li X, Yu L, Jiang Y, Gao F, Tong W, Yu H, Yang Z, Tong G*, Zhou Y*. Genetic evolution analysis and pathogenicity assessment of porcine epidemic diarrhea virus strains circulating in part of China during 2011-2017. Infect Genet Evol. 2019, 69:153-165.
(10). Wang K, Xie C, Zhang J, Zhang W, Yang D, Yu L, Jiang Y, Yang S, Gao F, Yang Z, Zhou Y*, Tong G*. The Identification and Characterization of Two Novel Epitopes on the Nucleocapsid Protein of the Porcine Epidemic Diarrhea Virus. Sci Rep. 2016 Dec 19;6:39010.
4. Representative Patents
(1). Porcine Epidemic Diarrhea Virus vaccine and its preparation method, national invention patent, 202110187738.3.
(2). Monoclonal antibody of Porcine Delta Coronavirus N protein, epitope and application thereof, national invention patent, ZL201711127879.6.
(3). Attenuated vaccine strain marked by genetic engineering of Porcine Reproductive and Respiratory Syndrome Virus and application thereof, national invention patent, ZL201110146821.2.
(4). ELISA differential diagnosis kit for PRRSV gene-labeled vaccine strain, method and application thereof, national invention patent, ZL201310240060.6.
(5). ELISA differential diagnosis kit for PRRSV gene-labeled vaccine strain, method and application thereof, national invention patent, ZL201310217805.7.
(6). RT-PCR differential diagnosis kit for Porcine Epidemic Diarrhea Virus and its application, national invention patent, ZL201310217682.7.
(7). Infectious clone vaccine strain of Porcine Reproductive and Respiratory Syndrome Virus and application thereof, national invention patent, ZL201010559005.X.
(8). Recombinant PRRSV attenuated vaccine strain expressing GM-CSF, preparation method and application thereof, national invention patent, ZL201410056557.7.
(9). Construction method and application of PRRSV recombinant plasmid expressing luciferase gene of Renila or Firefly, national invention patent, ZL201510069182.2
(10). Virulent strain of Porcine Reproductive and Respiratory Syndrome Virus, attenuated vaccine strain thereof and application thereof, national invention patent，ZL200810097546.8.