Chunchun MENG
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: basic and applied research on Feline calicivirus (FCV), and Newcastle disease virus (NDV)
1. Introduction
Chunchun Meng, male, born in 1984, PhD, researcher. Young talent of the Chinese Academy of Agricultural Sciences, executive chief of the Companion Animal Biosafety Risk Warning and Prevention Technology R＆D Team. Mainly engaged in the epidemiological investigation of important pathogens of companion animals and development of diagnostic reagents and vaccines. Already presided 3 projects supported by National Key Research and Development Program of China during 13th/14th Five-Year Plan. And several research plans approved by National Natural Science Foundation of China, National Natural Science Foundation of Shanghai. Published more than 100 academic research papers, of which 18 were SCI papers and as the first or corresponding author with a total impact factor more than 80 points. Furthermore, he has filed 21 patent applications, 14 of which have been granted authorization.
2. Research Interests
Dr. Meng majority focus on basic and applied research on Feline calicivirus (FCV), and Newcastle disease virus (NDV).
(1) Study on the mechanism of virus-host interaction:
Firstly, the concept of “specialized ribosome” was introduced to study the molecular mechanism by which NDV hijack and modify the host ribosome to translate viral proteins. Secondly, multi-omics methods were used to study the molecular mechanisms of changes in pathogenicity of NDV.Thirdly, the role of NS2 protein in adjust FCV replication and transcription.
（2）Research and development of new vaccines and therapeutic biologics against feline disease:
Firstly, conduct epidemiological investigations on important infectious diseases, isolate pathogens, study pathogenic mechanisms, and develop corresponding diagnostic methods and effective vaccines.
Secondly, utilize genetic engineering techniques to develop effective drugs for cat diseases.
3. Selected publication
(1). Tang J, Tang A, Jia N, Du H, Liu C, Zhu J, Li C, Meng C, Liu G. 2022. Free ISG15 Inhibits the Replication of Peste des Petits Ruminants Virus by Breaking the Interaction of Nucleoprotein and Phosphoprotein. Microbiol Spectr doi:10.1128/spectrum.01031-22:e0103122.（Corresponding author，IF="9.46）
(2). Tang J, Tang A, Du H, Jia N, Zhu J, Li C, Meng C, Liu G. 2022. Peste des Petits Ruminants Virus Exhibits Cell-Dependent Interferon Active Response. Front Cell Infect Microbiol 12:874936.( Corresponding author，IF="6.32)
(3). Qi R, Meng C, Zhu J, Li H, Miao Q, Tang J, Tang A, Guo H, Liu C, Li C, Chen Z, Wang F, Zhang Q, Liu G. 2022. The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen. Virol Sin 37:623-626.(First author，IF="6.46)
(4). Rehman ZU, Ren S, Butt SL, Manzoor Z, Iqbal J, Anwar MN, Sun Y, Qiu X, Tan L, Liao Y, Song C, Liu W, Meng C, Ding C. 2021. Newcastle Disease Virus Induced Pathologies Severely Affect the Exocrine and Endocrine Functions of the Pancreas in Chickens. Genes (Basel) 12.（Corresponding author，IF="4.05）
(5). Li Y, Rehman ZU, Li M, Manzoor Z, Liu W, Qiu X, Sun Y, Liao Y, Tan L, Song C, Liu W, Yu S, Ding C, Meng C. 2021. Comparison of the protective antigen variabilities of prevalent Newcastle disease viruses in response to homologous/heterologous genotype vaccines. Poult Sci 100:101267.（Corresponding author，IF="3.55）
(6). Rehman ZU, Ren S, Yang B, Yang X, Butt SL, Afzal A, Malik MI, Sun Y, Yu S, Meng C, Ding C. 2020. Newcastle disease virus induces testicular damage and disrupts steroidogenesis in specific pathogen free roosters. Vet Res 51:84.（Corresponding author，IF="3.68）
(7). Meng C, Huang Y, Rehman ZU, Hu W, Li C, Liang R, Chen Z, Song K, Wei T, Liu G. 2020. Development of an MCA-Based Real Time RT-qPCR Assay for the Simultaneous Detection and Differentiation of Duck Hepatitis A Virus Types 1 and 3. Virol Sin 35:666-669.（First author，IF="4.32）
(8). Liu P, Yin Y, Gong Y, Qiu X, Sun Y, Tan L, Song C, Liu W, Liao Y, Meng C, Ding C. 2019. In Vitro and In Vivo Metabolomic Profiling after Infection with Virulent Newcastle Disease Virus. Viruses 11.（Corresponding author，IF="5.04）
(9). Rehman ZU, Qiu X, Sun Y, Liao Y, Tan L, Song C, Yu S, Ding Z, Munir M, Meng C, Ding C. 2018. Vitamin E Supplementation Ameliorates Newcastle Disease Virus-Induced Oxidative Stress and Alleviates Tissue Damage in the Brains of Chickens. Viruses 10.（Corresponding author，IF="5.04）
(10). Rehman ZU, Meng C, Sun Y, Mahrose KM, Umar S, Ding C, Munir M. 2018. Pathobiology of Avian avulavirus 1: special focus on waterfowl. Vet Res 49:94.（First author，IF="3.68）
(11). Rehman ZU, Che L, Ren S, Liao Y, Qiu X, Yu S, Sun Y, Tan L, Song C, Liu W, Ding Z, Munir M, Nair V, Meng C, Ding C. 2018. Supplementation of Vitamin E Protects Chickens from Newcastle Disease Virus-Mediated Exacerbation of Intestinal Oxidative Stress and Tissue Damage. Cell Physiol Biochem 47:1655-1666.（Corresponding author，IF="5.10）
(12). Meng C, Rehman ZU, Liu K, Qiu X, Tan L, Sun Y, Liao Y, Song C, Yu S, Ding Z, Nair V, Chan D. 2018. Potential of genotype VII Newcastle disease viruses to cause differential infections in chickens and ducks. Transbound Emerg Dis doi:10.1111/tbed.12965.（First author，IF="5.0）
(13). Meng C, Zhi X, Li C, Li C, Chen Z, Qiu X, Ding C, Ma L, Lu H, Chen D, Liu G, Cui D. 2016. Graphene Oxides Decorated with Carnosine as an Adjuvant To Modulate Innate Immune and Improve Adaptive Immunity in Vivo. ACS Nano 10:2203-2213.（First author，IF="13.88）
(14). Meng C, Qiu X, Yu S, Li C, Sun Y, Chen Z, Liu K, Zhang X, Tan L, Song C, Liu G, Ding C. 2016. Evolution of Newcastle Disease Virus Quasispecies Diversity and Enhanced Virulence after Passage through Chicken Air Sacs. J Virol 90:2052-2063.（First author，IF="5.32）
(15). Meng C, Zhou Z, Jiang K, Yu S, Jia L, Wu Y, Liu Y, Meng S, Ding C. 2012. Newcastle disease virus triggers autophagy in U251 glioma cells to enhance virus replication. Arch Virol 157:1011-1018.（First author，IF="2.57）
(16). Meng C, Qiu X, Jin S, Yu S, Chen H, Ding C. 2012. Whole genome sequencing and biological characterization of Duck/JS/10, a new lentogenic class I Newcastle disease virus. Arch Virol 157:869-880.（First author，IF="2.57）
4. Contact Information
Tel: 021-54225512
E-mail: mengcc@shvri.ac.cn