Changlong LIU

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Fields: porcine epidemic diarrhea virus and other swine infectious virus

1. Introduction

Prof. LIU is a Principal Investigator at SHVRI, CAAS. He received his PhD degree from Chinese Academy of Agricultural Sciences, has conducted postdoctoral research at the University of Alabama at Birmingham and University of South Carolina. He joined the Shanghai Veterinary Research Institute in August 2019. He has been recognized as the Shanghai "Pujiang Talent Plan (Class A)" and as the "Young Talent" by the Chinese Academy of Agricultural Sciences. Dr. Liu Lab mainly focus on the porcine epidemic diarrhea virus and other swine infectious virus. His research utilizes porcine organoids, gene editing, whole-genome CRISPR/Cas9 genetic screening, machine learning, and mutiple omics combined with cellular biochemistry and reverse genetics to deeply explore the interactions between viruses and their hosts. Currently, he has published many high-impact papers as the first author or corresponding author in prestigious journals such as PNAS, Cancer Research, Viruses, Virus Research and so on. He has been granted 2 national invention patents and 1 U.S. patent.

2. Contact Information

Address: A415, No. 518, Ziyue RD, Minhang, Shanghai

Postcode: 200241

Email: liuchanglong@shvri.ac.cn

3. Publications

(1) Huaye Luo, Lilei Lv, Jingxuan Yi, Yanjun Zhou, Changlong Liu*. Establishment of Replication Deficient Vesicular Stomatitis Virus for Studies of PEDV Spike-Mediated Cell Entry and Its Inhibition. Microorganisms, 2023, 11(8).

(2) Min Zhang, Lilei Lv, Huaye Luo, Hongming Cai, Lingxue Yu, Yifeng Jiang, Fei Gao, Wu Tong, Liwei Li, Guoxin Li, Yanjun Zhou, Guangzhi Tong*，Changlong Liu*. The CD2v protein of African swine fever virus inhibits macrophage migration and inflammatory cytokines expression by downregulating EGR1 expression through dampening ERK1/2 activity [J]. Vet Res, 2023, 54(1): 106.

(3) Lilei Lv, Huaye Luo, Lingxue Yu, Wu Tong, Yifeng Jiang, Guoxin Li, Guangzhi Tong, Yanhua Li*, Changlong Liu*. Identification and Characterization of Cell Lines HepG2, Hep3B217 and SNU387 as Models for Porcine Epidemic Diarrhea Coronavirus Infection. Viruses, 2022, 14(12).

(4) Min Zhang; Lilei Lv; Hongming Cai; Yanhua Li; Fei Gao; Lingxue Yu; Yifeng Jiang; Wu Tong; Liwei Li; Guoxin Li; Guangzhi Tong*; Changlong Liu*. Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection. Front Microbiol, 2022, 13: 865336.

(5) Yujiao Zhang, Fei Gao, Liwei Li, Kuan Zhao, Shan Jiang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Changlong Liu*, Guangzhi Tong*. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity. Viruses, 2020. 12(6).

(6) Changlong Liu, Carolyn E. Banister and Phillip J. Buckhaults. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Cancer Researh, 2019. 79(9): p. 2392-2403.

(7) Changlong Liu, Carolyn E. Banister, Charles C. Weige, Diego Altomare, Joseph H. Richardson, Carlo M. Contreras and Phillip J. Buckhaults. PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A, 2018. 115(22): p. E5066-E5075.

(8) Changlong Liu, Huawei Ding, Wenbo Zhu, Shaojie Jiang, Jianrong Xu, GangMing Zou. LIGHT regulates the adipogenic differentiation of mesenchymal stem cells. J Cell Biochem, 2013. 114(2): p. 346-53.

4.Patents

Phillip J. Buckhaults; Changlong Liu; Carolyn E. Banister. Methods For Resensitizing P53-Null Cells To Cancer Chemotherapy, 2021, USA, US2020/0299777A1。