Houshuang ZHANG

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Feilds:  Zoonotic diseases and veterinary public health

1. Introduction

Zhang Houshuang, Ph.D., Professor, doctoral supervisor, adjunct professor as master's tutor at Tarim University and young editorial board member of "Chinese Journal of Parasitology and Parasitic Diseases". The Leading Talent in Minhang District, Shanghai. The major research field is parasitology, to explore the pathogenic mechanism of parasites, functions of genes and proteins, molecular diagnostic methods, epidemiological surveys and research on new vaccines, aiming to elucidate the role of parasites in the process of disease transmission. Complex molecular mechanisms that interact with invaded host cells. In addition, molecular screening of important virulence and function-related genes of parasites, especially  Toxoplasma gondii , is also studied the functions systematically, with a view to further exploring new anti-parasitic drug targets or vaccine candidate antigens. He won the third prize of China Medical Science and Technology Award. At present, he has hosted and completed more than 10 national, provincial and ministerial level projects; he has participated in the completion of 9 projects as the main executor. Currently, he is hosting 2 national and Shanghai projects and is participating in 2 projects. Trained more than 10 master's degree students. He has published more than 80 research papers in domestic and foreign academic journals, including more than 50 SCI papers. Participated in editing 2 books. He has obtained 6 national invention patents.

2. Contact Information

Tel: 0086-21-34293411

Email: zhanghoushuang@shvri.ac.cn

3. Major Publications

(1). Cai Q, Lei M, Li C, Cai J, Ma D, Zhang H*. Epidemiological Investigation of Yak (Bos grunniens) Fascioliasis in the Pastoral Area of Qinghai-Tibet Plateau, China. Animals (Basel). 2023; 13(21):3330.

(2). Gebremedhin MB, Xu Z, Kuang C, Shumuye NA, Cao J, Zhou Y, Zhang H*, Zhou J. Current Knowledge on Chemosensory-Related Candidate Molecules Potentially Involved in Tick Olfaction via Haller's Organ. Insects. 2023; 14(3):294.

(3). Lu J, Wei N, Cao J, Zhou Y, Gong H, Zhang H*, Zhou J*. Evaluation of enzymatic activity of  Babesia microti  thioredoxin reductase (Bmi TrxR)-mutants and screening of its potential inhibitors. Ticks Tick Borne Dis. 2021; 12(2):101623.

(4). Zhang H, Wang Z, Huang J, Cao J, Zhou Y, Zhou J. A Novel Thioredoxin-Dependent Peroxiredoxin (TPx-Q) Plays an Important Role in Defense Against Oxidative Stress and Is a Possible Drug Target in  Babesia microti . Front Vet Sci. 2020; 7:76.

(5). Wang Y, Zhang H, Luo L, Zhou Y, Cao J, Xuan X, Suzuki H, Zhou J. ATG5 is instrumental in the transition from autophagy to apoptosis during the degeneration of tick salivary glands. PLoS Negl Trop Dis. 2021; 15(1):e0009074.

(6). Svitek N, Saya R, Zhang H, Nene V, Steinaa L. Systematic Determination of TCR-Antigen and Peptide-MHC Binding Kinetics among Field Variants of a Theileria parva Polymorphic CTL Epitope. J Immunol. 2022; 208(3):549-561.

(7). Wei N, Cao J, Zhang H, Zhou Y, Zhou J. The Tick Microbiota Dysbiosis Promote Tick-Borne Pathogen Transstadial Transmission in a Babesia microti-Infected Mouse Model. Front Cell Infect Microbiol. 2021; 11:713466.

(8). Xu Z, Yan Y, Zhang H, Cao J, Zhou Y, Xu Q, Zhou J. A serpin from the tick Rhipicephalus haemaphysaloides: Involvement in vitellogenesis. Vet Parasitol. 2020; 279:109064.

(9). Nawaz M, Malik MI, Zhang H, Gebremedhin MB, Cao J, Zhou Y, Zhou J. miRNA profile of extracellular vesicles isolated from saliva of Haemaphysalis longicornis tick. Acta Trop. 2020; 212:105718.

(10). Nawaz M, Malik MI, Zhang H, Hassan IA, Cao J, Zhou Y, Hameed M, Hussain Kuthu Z, Zhou J. Proteomic Analysis of Exosome-Like Vesicles Isolated From Saliva of the Tick  Haemaphysalis longicornis . Front Cell Infect Microbiol. 2020; 10:542319.

4. Patents

(1). Primers, probes and kits for detecting bradyzoites of  Toxoplasma gondii , 2014-9-3, China, ZL201210072527.6

(2). Evil ketoneses Lin - 1, 4-2 oxygen compounds in the application of anti- toxoplasma infection, 2022-5-17, China, ZL201910400204.7

(3). Tick apoptosis inhibiting protein IAP and its gene and application, 2022-7-15, China, ZL201910982130.2

(4). Thioredoxin molecules, Genes and Applications of  Babesia microtii , 2020-12-15, China, ZL201610539065.2

5. Rewards

(1). The third Prize of China Medical Science and Technology Award, Innovation and Application of Early Diagnosis, Source Tracing, Prevention and Control Technology of Babesiosis, Malaria and other Important vecter-borne Diseases,  2021 (15th Complete Person) .

(2). The third Prize of Chinese preventive medical association awards fibronectin expression, "the barber worm disease, malaria, and other important vector-borne disease early detection, and prevention and control technology and application", 2021 (15th Complete Person).

(3). The Second Prize of Science and Technology Progress Award of Xinjiang Uygur Autonomous Region, "Establishment and Application of Key Technologies for the Prevention and Control of Biological Vector Tick and Protozoan Disease", 2023 (5th Complete Person).