Xusheng QIU

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Fields:The development of innovative vaccines and detection technology for avian viral infectious diseases, including Newcastle disease, Infectious Bursal Disease, and Marek's disease. Research on the pathogenic mechanisms, evolutionary rules, and interaction between viral proteins and host cellular proteins.

1. Introduction

Xusheng, Doctor, Researcher, Doctoral Supervisor, the Secretary of the Seventh Party Branch. I have been engaged in the research on Avian Virology for a long time, including the development of novel vaccines and detection technology for avian viral infectious diseases such as Newcastle disease, Infectious Bursal Disease and Marek's disease. Furthermore, my research delves into exploring viral pathogenic mechanism, evolutionary rules, and the interaction between viral proteins and host cellular proteins. Presided over 5 national and provincial level projects, and trained 16 master students (including joint training students). My research findings have been published in reputable domestic and international journals such as  Journal of Virology ,  Viruses , and  Plos Pathogens . In total, I have published 93 papers, with 37 of them being SCI papers. Furthermore, I have contributed to a special issue and have obtained four patents, one GMO safety certificate (second place) and one clinical trial approval (second place). I won the first prize (11th place) of the 2016 Higher Education Institutions Scientific Research Excellence Award, the second prize (15th place) of the 2016 Shanghai Science and Technology Award and the second prize (10th place) of the 2016 Jiangsu Science and Technology Award.

2. Contact Information

Phone：021-34293426

Email：xsqiu1981@shvri.ac.cn

3. Major Journal Articles

[1] Peng T, Qiu X, Tan L, Yu S, Yang B, Dai J, Liu X, Sun Y, Song C, Liu W, Meng C, Liao Y, Yuan W, Ren T, Liu X, Ding C. Ubiquitination on Lysine 247 of Newcastle Disease Virus Matrix Protein Enhances Viral Replication and Virulence by Driving Nuclear-Cytoplasmic Trafficking. Journal of Virology 2022, 96(2): e0162921.

[2] Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH, Ding C. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy 2021: 1-19.

[3] Zhan Y, Yu S, Yang S, Qiu X, Meng C, Tan L, Song C, Liao Y, Liu W, Sun Y, Ding C. Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E. PLoS pathogens 2020, 16(6): e1008610.

[4] Li X, Feng Y, Liu W, Tan L, Sun Y, Song C, Liao Y, Xu C, Ren T, Ding C, Qiu X. A Role for the Chicken Interferon-Stimulated Gene CMPK2 in the Host Response Against Virus Infection.  Front Microbiol 2022, 13:874331.

[5] Tan L, Wen G, Yuan Y, Huang M, Sun Y, Liao Y, Song C, Liu W, Shi Y, Shao H, Qiu X, Ding C. Development of a Recombinant Thermostable Newcastle Disease Virus (NDV) Vaccine Express Infectious Bronchitis Virus (IBV) Multiple Epitopes for Protecting against IBV and NDV Challenges. Vaccines (Basel) 2020, 8(4).

[6] Sun Y, Zheng H, Yu S, Ding Y, Wu W, Mao X, Liao Y, Meng C, Ur Rehman Z, Tan L, Song C, Qiu X, Wu F, Ding C. Newcastle Disease Virus V Protein Degrades Mitochondrial Antiviral Signaling Protein To Inhibit Host Type I Interferon Production via E3 Ubiquitin Ligase RNF5. Journal of Virology 2019, 93(18).

[7] Meng C, Rehman ZU, Liu K, Qiu X, Tan L, Sun Y, Liao Y, Song C, Yu S, Ding Z, Nair V, Munir M, Ding C. Potential of genotype VII Newcastle disease viruses to cause differential infections in chickens and ducks. Transbound Emerg Dis 2018, 65(6): 1851-1862.

[8] Liu W, Qiu X, Song C, Sun Y, Meng C, Liao Y, Tan L, Ding Z, Liu X, Ding C. Deep Sequencing-Based Transcriptome Profiling Reveals Avian Interferon-Stimulated Genes and Provides Comprehensive Insight into Newcastle Disease Virus-Induced Host Responses. Viruses 2018, 10(4).

[9] Meng C, Qiu X, Yu S, Li C, Sun Y, Chen Z, Liu K, Zhang X, Tan L, Song C, et al: Evolution of Newcastle Disease Virus Quasispecies Diversity and Enhanced Virulence after Passage through Chicken Air Sacs. J Virol 2016, 90:2052-2063.

[10] Qiu X, Fu Q, Meng C, Yu S, Zhan Y, Dong L, Song C, Sun Y, Tan L, Hu S, et al: Newcastle Disease Virus V Protein Targets Phosphorylated STAT1 to Block IFN-I Signaling. PLoS One 2016, 11:e0148560.

4. Patents and Standards

[1] A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF, Authorization time：2022.04.19，US Patent No.：US 11,305,007,B2.

[2] A composite multi-epitope expression box, a recombinant virus composed of the same and its application. Authorization time：2022.06.10，China patent number：ZL201810394542.

[3] Stable expression of hamster TIGAR gene BHK cell line and its construction method and application. Authorization time：2021.8，China patent number：ZL201910344592.1

[4] A mitochondrial antiviral signaling protein from geese and its application. Authorization time: 2021.08.03，China patent number：ZL201810367202.8

[5] A goose-derived gene RIG-I with anti-newcastle disease virus activity and its application. Authorization time：2016年2月3日，China patent number：ZL201210281895.1

[6] CD8+ T cell epitope polypeptide of chicken IBV S1 protein. Authorization time：2016.2.3，China patent number：ZL 201310317878.3

5. Achievements and Awards

[1] First Prize of Scientific Research Excellence Award 2016, Evolution of Newcastle Disease Virus and Creation of a new Gene VII vaccine in China, Liu Xiufan, Hu Shunlin, Liu Xiaowen, He Hairong, Wang Xiaoquan, Wu Yantao, Hu Zenglei, Gu Min, Huang Yong, Cao Yongzhong, Qiu Xusheng, Wang Yuyang, December 2016.

[2] Second Prize of Shanghai Science and Technology Award 2016, Rapid Diagnosis and Vaccine Research of Major Diseases in Waterbirds, Ding Zhao, Yu Shengqing, Shao Huabin, Wang Mingshu, Zhang Dabing, Chen Shaoying, Peng Daxin, Huang Yu, Xu Chuantian, Hu Qilin, Qin Aijian, Liu Guangqing, Cheng Anchun, Li Zejun, Qiu Xusheng, August 2016.

[3] The Second Prize of Jiangsu Province Science and Technology Award 2016, Research and Application of Rapid Diagnosis and Control Technology of Major Waterfowl Diseases, Ding Shao, Zhu Shanyuan, Yu Shengqing, Cheng Anchun, Chen Shaoying, Shao Huabin, Wang Mingshu, Qiu Xusheng, Wang Yongjuan, Wang Anping, Zuo Weiyong, 2016.