Hai YU

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Fields: Molecular epidemiology of porcine viral disease, development of genetically engineered vaccines, and molecular pathogenesis

1. Introduction

Yu Hai, Ph.D., professor, doctoral supervisor, research scientist of the research team for the prevention and control of porcine viral reproductive disorders, member of the Veterinary Microbiology Professional Committee of the Chinese Society of Microbiology, and member of the Young Scholars Professional Group of the Animal Infectious Diseases Branch of the Chinese Society of Animal Husbandry and Veterinary Medicine. In 2010, Professor Yu was awarded the "National Excellent Doctoral Dissertation Award" by the Ministry of Education and the Academic Degrees Committee of the State Council; In 2015, Professor Yu was selected as a leading talent in Minhang District, Shanghai. In 2016, Professor Yu was selected as a member of the Youth Talent Program of the Chinese Academy of Agricultural Sciences for the cultivation of scientific research talents.

Professor Yu engaged in long-term research on molecular epidemiology of porcine viral diseases, development of genetically engineered vaccines, and molecular pathogenic mechanisms, and completed the transformation of one scientific and technological achievement. Professor Yu hosted national natural science foundation projects, national international science and technology cooperation sub projects, national natural science foundation youth projects, Shanghai natural science foundation and other projects, and trained (including joint training) 2 doctoral students and 17 master's students. Professor Yu published 30 SCI papers as the first or corresponding author in journals such as Emerging Infectious Diseases, Journal of Infection, Journal of Clinical Microbiology, Transboundary and Emerging Diseases, and Veterinary Microbiology, and served as the deputy editor in chief to write one monograph on Swine Influenza, obtaining 8 patents.

2. Contact Information

Tel.: +86-21-34293337

Email: haiyu@shvri.ac.cn

3. Publications

(1) Shuai-Yong Wang, Feng Wen, Ling-Xue Yu, Juan Wang, Man-Zhu Wang, Jie-Cong Yan, Yan-Jun Zhou, Wu Tong, Tong-Ling Shan, Guo-Xin Li, Hao Zheng, Chang-Long Liu, Ning Kong, Guang-Zhi Tong, Hai Yu*. Eurasian Avian-Like Swine Influenza A(H1N1) Virus and Its Reassortant Viruses are Potential Threats to Human Health. Emerging Infectious Diseases, 2022, 28(7):1489-1493.

(2) Ying-Feng Sun*, Ye Liu, Jing Yang, Wen-Zhong Li, Xiao-Xue Yu, Liu-An Li, Shuai-Yong Wang, Hai Yu*. Recombination between NADC34-like and QYYZ-like strain of Porcine Reproductive and Respiratory Syndrome virus with high pathogenicity for piglets in China. Transboundary and Emerging Diseases, 2022. 2022, 69(5):e3202-e3207..

(3) Ying-Feng Sun, Jing Yang, Ye Liu, Wen-Zhong Li, Xiao-Xue Yu, Liu-An Li*, Hai Yu*. Emergence of Novel Recombinant Type 2 Porcine Reproductive and Respiratory Syndrome Viruses with high pathogenicity for piglets in China. Journal of infection, 2021, 83(5):607-635.

(4) Jinyue Guo#, Hai Yu#, Congying Wang#, Sheng Yuan, Hailiang Sun, Jing Yang, Qing Cheng, Kaijian Luo, Yong Li, Zhili Li, Quan Liu, Shujian Huang, Feng Wen*. Re-emergence of Highly Pathogenic Avian Influenza A(H5N8) Virus In Domestic Goose, China. Journal of infection, 2021, 83(6):709-737.

(5) Jinyue Guo#, Hai Yu#, Jing Yang, Yong Li, Xuelian Zhang, Kun Mei, Shihong Chi, Sheng Yuan, Hao Liu, Saeed El-Ashram, Shujian Huang, Feng Wen*. Weighted gene co-expression network analysis revealed host transcriptional response to H1N1 influenza A virus infection. Journal of infection, 2021, 82(3):e4-e7.

(6) Bao-Yang Ruan#, Yun Yao#, Shuai-Yong Wang#, Xiao-Qian Gong, Xiao-Min Liu, Qi Wang, Ling-Xue Yu, Shi-Qiang Zhu, Juan Wang, Tong-Ling Shan, Yan-Jun Zhou, Wu Tong, Hao Zheng, Guo-Xin Li, Fei Gao, Ning Kong, Hai Yu*, Guang-Zhi Tong, Protective efficacy of a bivalent inactivated reassortant H1N1 influenza virus vaccine against European avian-like and Classical swine influenza H1N1 viruses in mice, veterinary microbiology, 2020, 246:108724.

(7) Xiu-Hui Wang#, Xiao-Qian Gong#, Feng Wen#, Bao-Yang Ruan, Ling-Xue Yu, Xiao-Min Liu, Qi Wang, Shuai-Yong Wang, Juan Wang, Yi-Feng, Zhang, Yan-Jun Zhou, Tong-Ling Shan, Wu Tong, Hao Zheng, Ning Kong, Hai Yu*, Guang-Zhi Tong, The Role of PA-X C-Terminal 20 Residues of Classical Swine Influenza Virus in Its Replication and Pathogenicity, veterinary microbiology, 2020, 251:108916.

(8) Ying-Feng Sun, Lei Zhou, Ting Bian, Xiang-Xue Tian, Wei-Ke Ren, Chao Lu, Li Zhang, Xiu-Li Li, Mao-Sheng Cui, Han-Chun Yang*, Hai Yu*. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus, veterinary microbiology, 2018, 216:176-182.

(9) Bao-Yang Ruan#, Feng Wen#, Xiao-Qian Gong, Xiao-Min Liu, Qi Wang, Ling-Xue Yu, Shuai-Yong Wang, Peng Zhang, Hai-Ming Yang, Tong-Ling Shan, Hao Zheng, Yan-Jun Zhou, Wu Tong, Fei Gao, Guang-Zhi Tong*, Hai Yu*. Protective efficacy of a high-growth reassortant H1N1 influenza virus vaccine against the European Avian-like H1N1 swine influenza virus in mice and pigs, veterinary microbiology, 2018, 222:75-84.

(10) Xiao-Qian Gong, Ying-Feng Sun, Bao-Yang Ruan,Xiao-Min Liu, Qi Wang, Hai-Ming Yang, Shuai-Yong Wang, Peng Zhang, Xiu-Hui Wang, Tong-Ling Shan, Wu Tong, Yan-Jun Zhou, Guo-Xin Li, Hao Zheng, Guang-Zhi Tong*, Hai Yu*. PA-X protein decreases replication and pathogenicity of swine influenza virus in cultured cells and mouse models, veterinary microbiology, 2017, 205:66-70.

4. Patents

(1) Recombinant European avian H1N1 subtype swine influenza vaccine strain and its preparation method and application, September 3, 2019 (authorized), China, ZL201510477308. X

(2) Porcine Reproductive and Respiratory Syndrome Virus Infectious Cloned Vaccine Strain and Its Application, March 27, 2013 (authorized), China, ZL201010559005. X

(3) Expression of GM-CSF recombinant PRRSV attenuated vaccine strain and its preparation method and application, March 22, 2017 (authorized), China, ZL201410056557.7

(4) Pseudorabies virus gene deletion attenuated strain and its preparation method and application, September 7, 2018 (authorized), China, ZL20141002656.7

(5) Pig derived Geta virus antibodies, hybridoma cell lines and their applications, July 8, 2020 (application), China, 202010649175.0