Lei TAN
Professional Title: Professor
Education: PhD
Supervisor Category: Master Supervisor
Research Fields: Genetic engineering vaccine design; Regulation of host natural immunity and acquired immunity by viruses; Veterinary microorganisms and molecular biology; Interaction between the virus and cell host
1. Contact Information
Address:No.518, Ziyue Road, Minhang District, Shanghai 200241, People’s Republic of China
Email: tanlei@shvri.ac.cn
2. Experience
Oct, 2023- present: Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Jan, 2017-Sep, 2023: Associate Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Oct, 2017- Oct, 2018: Visiting Scholar/Scientist, Stanford University
Dec, 2016- Jul 2011: Assistant Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Memberships in Professional Societies:
Director, the Branch of Veterinary Public Health, Chinese Association of Animal Science and Veterinary Medicine. 2018-present.
3. Fundings
[1]. Key project supported by the National Natural Science Foundation of China, U23A20239, Research on the mechanism of viral envelope proteins regulating the thermal stability of Newcastle disease vaccine strains, 2024-1 to 2027-12, Project is in progress;
[2]. Sub-project of the National Key Research and Development Plan, 2022YFD1801000, Creation of New Vaccines for Avian Viral Diseases, 2022-11 to 2025-12, Project is in progress;
[3]. National Natural Science Foundation of China General Project, 32072868, Research on the mechanism of Newcastle disease virus using the chicken AXL/Mertk receptor system to inhibit the type I interferon pathway, 2021-01 to 2024-12, Project is in progress;
[4]. National Natural Science Foundation of China General Project, 31772725, Research on the uptake of Newcastle disease virus by chicken dendritic cells through macropinocytosis pathway and its antigen presentation mechanism, 2018-01 to 2019-12, completed;
[5]. Sub-topic of the National Key R&D Plan Project, 2017YFD0500702-2, Research and Development of Comprehensive Technology for Prevention and Control of Major Livestock and Poultry Diseases and Safe and Efficient Breeding, 2017-07 to 2020-12, completed;
[6]. National Natural Science Foundation of China Youth Fund Project, 31402182, Research on the inhibitory effect of dendritic cells on T lymphocyte proliferation in chickens infected with Newcastle disease virus, 2015-01 to 2017-12, completed.
4. Publications
[1]: Tan L, Huang M, Qiu X, Zhi X, Liang L, Sun Y, Liao Y, Song C, Ren T, Ding C. Chicken-derived MERTK protein inhibits Newcastle disease virus replication by increasing STAT1 phosphorylation in DF-1 cells. Virus Res. 2023 Mar;326:199065. doi: 10.1016/j.virusres.2023.199065. Epub 2023 Feb 8. PMID: 36754292; PMCID: PMC10194215.
[2]: Dai J, Wang H, Liao Y, Tan L, Sun Y, Song C, Liu W, Qiu X, Ding C. RNA-seq and LC-MS/MS analysis of antiviral effects mediated by cold stress and stress hormone corticosterone in chicken DF-1 cells. Vet Microbiol. 2022 Dec;275:109580. doi: 10.1016/j.vetmic.2022.109580. Epub 2022 Oct 21. PMID: 36308941.
[3]: Dai J, Wang H, Liao Y, Tan L, Sun Y, Song C, Liu W, Ding C, Luo T, Qiu X. Non-Targeted Metabolomic Analysis of Chicken Kidneys in Response to Coronavirus IBV Infection Under Stress Induced by Dexamethasone. Front Cell Infect Microbiol. 2022 Jul 15;12:945865. doi: 10.3389/fcimb.2022.945865. PMID: 35909955; PMCID: PMC9335950.
[4]: Li X, Feng Y, Liu W, Tan L, Sun Y, Song C, Liao Y, Xu C, Ren T, Ding C, Qiu X. A Role for the Chicken Interferon-Stimulated Gene CMPK2 in the Host Response Against Virus Infection. Front Microbiol. 2022 May 11;13:874331. doi: 10.3389/fmicb.2022.874331. PMID: 35633731; PMCID: PMC9132166.
[5]: Dai J, Wang H, Liao Y, Tan L, Sun Y, Song C, Liu W, Qiu X, Ding C. Coronavirus Infection and Cholesterol Metabolism. Front Immunol. 2022 Apr 21;13:791267. doi: 10.3389/fimmu.2022.791267. PMID: 35529872; PMCID: PMC9069556.
[6]: Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH, Ding C. Newcastle disease virus degrades SIRT3 via PINK1-PRKN- dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy. 2022 Jul;18(7):1503-1521. doi: 10.1080/15548627.2021.1990515. Epub 2021 Oct 31. PMID: 34720029; PMCID: PMC9298456.
[7]: Peng T, Qiu X, Tan L, Yu S, Yang B, Dai J, Liu X, Sun Y, Song C, Liu W, Meng C, Liao Y, Yuan W, Ren T, Liu X, Ding C. Ubiquitination on Lysine 247 of Newcastle Disease Virus Matrix Protein Enhances Viral Replication and Virulence by Driving Nuclear-Cytoplasmic Trafficking. J Virol. 2022 Jan 26;96(2):e0162921. doi: 10.1128/JVI.01629-21. Epub 2021 Oct 27. PMID: 34705566; PMCID: PMC8791254.
[8]: Wu W, Qu Y, Yu S, Wang S, Yin Y, Liu Q, Meng C, Liao Y, Ur Rehman Z, Tan L, Song C, Qiu X, Liu W, Ding C, Sun Y. Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity. mBio. 2021 Jun 29;12(3):e0100521. doi: 10.1128/mBio.01005-21. Epub 2021 Jun 14. PMID: 34125604; PMCID: PMC8262918.
[9]: Gao B, Gong X, Fang S, Weng W, Wang H, Chu H, Sun Y, Meng C, Tan L, Song C, Qiu X, Liu W, Forlenza M, Ding C, Liao Y. Inhibition of anti-viral stress granule formation by coronavirus endoribonuclease nsp15 ensures efficient virus replication. PLoS Pathog. 2021 Feb 26;17(2):e1008690. doi: 10.1371/journal.ppat.1008690. PMID: 33635931; PMCID: PMC7946191.
[10]: Tan L, Wen G, Yuan Y, Huang M, Sun Y, Liao Y, Song C, Liu W, Shi Y, Shao H, Qiu X, Ding C. Development of a Recombinant Thermostable Newcastle Disease Virus (NDV) Vaccine Express Infectious Bronchitis Virus (IBV) Multiple Epitopes for Protecting against IBV and NDV Challenges. Vaccines (Basel). 2020 Oct 1;8(4):564. doi: 10.3390/vaccines8040564. PMID: 33019497; PMCID: PMC7712034.
[11]: Zhan Y, Yu S, Yang S, Qiu X, Meng C, Tan L, Song C, Liao Y, Liu W, Sun Y, Ding C. Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E. PLoS Pathog. 2020 Jun 30;16(6):e1008610. doi: 10.1371/journal.ppat.1008610. PMID: 32603377; PMCID: PMC7326156.
[12]: Shi M, Tan L, Zhang Y, Meng C, Wang W, Sun Y, Song C, Liu W, Liao Y, Yu S, Ren T, Ding Z, Liu X, Qiu X, Ding C. Characterization and functional analysis of chicken APOBEC4. Dev Comp Immunol. 2020 May;106:103631. doi: 10.1016/j.dci.2020.103631. Epub 2020 Jan 25. PMID: 31991164.
[13]: Li Y, Jiang W, Niu Q, Sun Y, Meng C, Tan L, Song C, Qiu X, Liao Y, Ding C. eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus. Cell Death Dis. 2019 Nov 26;10(12):891. doi: 10.1038/s41419-019-2128-6. PMID: 31767828; PMCID: PMC6877643.
[14]: Tan L, Wen G, Qiu X, Yuan Y, Meng C, Sun Y, Liao Y, Song C, Liu W, Shi Y, Shao H, Ding C. A Recombinant La Sota Vaccine Strain Expressing Multiple Epitopes of Infectious Bronchitis Virus (IBV) Protects Specific Pathogen-Free (SPF) Chickens against IBV and NDV Challenges. Vaccines (Basel). 2019 Nov 1;7(4):170. doi: 10.3390/vaccines7040170. PMID: 31683905; PMCID: PMC6963182.
[15]: Sun Y, Zheng H, Yu S, Ding Y, Wu W, Mao X, Liao Y, Meng C, Ur Rehman Z, Tan L, Song C, Qiu X, Wu F, Ding C. Newcastle Disease Virus V Protein Degrades Mitochondrial Antiviral Signaling Protein To Inhibit Host Type I Interferon Production via E3 Ubiquitin Ligase RNF5. J Virol. 2019 Aug 28;93(18):e00322-19. doi: 10.1128/JVI.00322-19. PMID: 31270229; PMCID: PMC6714796.
[16]: Zhou C, Tan L, Sun Y, Qiu X, Liao Y, Song C, Liu W, Nair V, Ding C. Exosomes Carry microRNAs into Neighboring Cells to Promote Diffusive Infection of Newcastle Disease Virus. Viruses. 2019 Jun 6;11(6):527. doi: 10.3390/v11060527. PMID: 31174402; PMCID: PMC6631457.
[17]: Tan L, Zhang Y, Qiao C, Yuan Y, Sun Y, Qiu X, Meng C, Song C, Liao Y, Munir M, Nair V, Ding Z, Liu X, Ding C. NDV entry into dendritic cells through macropinocytosis and suppression of T lymphocyte proliferation. Virology. 2018 May;518:126-135. doi: 10.1016/j.virol.2018.02.011. Epub 2018 Mar 15. PMID: 29481983.
[18]: Tan L, Zhang Y, Liu F, Yuan Y, Zhan Y, Sun Y, Qiu X, Meng C, Song C, Ding C. Infectious bronchitis virus poly-epitope-based vaccine protects chickens from acute infection. Vaccine. 2016 Oct 17;34(44):5209-5216. doi: 10.1016/j.vaccine.2016.09.022. Epub 2016 Sep 21. PMID: 27665355.
[19]: Tan L, Liao Y, Fan J, Zhang Y, Mao X, Sun Y, Song C, Qiu X, Meng C, Ding C. Prediction and identification of novel IBV S1 protein derived CTL epitopes in chicken. Vaccine. 2016 Jan 12;34(3):380-6. doi: 10.1016/j.vaccine.2015.11.042. Epub 2015 Nov 25. PMID: 26620841.