中
Home Teams and Professors Professors

Teams and Professors

Introduction

Keyu ZHANG

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Fields: Veterinary pharmacology and new veterinary drugs research

1. Introduction

Zhang Keyu, doctoral student, researcher, master's supervisor, senior member of the Chinese Society of Animal Husbandry and Veterinary Medicine, executive director of the Veterinary Pharmacotoxicology Branch, and member of the Veterinary Toxicology Committee of the Chinese Society of Toxicology.

Engaged in research on veterinary pharmacology and new veterinary drugs for a long time, as the main contributor to research and development, and obtained five national certificates for new veterinary drugs. Received the first prize of the Dabei Agricultural Science and Technology Innovation Award, the first Youth Innovation Talent Award of the Animal Medicine Credit Committee of the China Society of Animal Husbandry and Veterinary Medicine, and was selected as a leading talent in Minhang District. Hosted multiple scientific research tasks, including the National Natural Science Foundation (General), the 13th Five Year National Key R&D Program sub project, the National Science and Technology Support Program sub project, and the Ministry of Agriculture's public welfare industry (agriculture) research special task, and trained (including joint training) 11 master's students. I have published over 60 papers both domestically and internationally, including Cell BIOL TOXICOL, Bioorg Chem, Inflammation, and Regul Toxic Pharmacol. Among them, I have published over 40 SCI papers and obtained 6 patents.


2. Contact Information

Tel：021-34293396

E-mail：zcole@shvri.ac.cn

3. Publications

(1) Ye W, et al.. Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity. Eur J Med Chem. 2024 Jan 15;264:115988.

(2) Li X, et al.. Effects of ethanamizuril, sulfachlorpyridazine or their combination on cecum microbial community and metabolomics in chickens infected with Eimeria tenella. Microb Pathog. 2022 Dec;173(Pt A):105823.

(3) Cheng X, et al.. Effects of salinomycin and ethanamizuril on the three microbial communities in vivo and in vitro. Front Microbiol. 2022 Aug 12;13:941259.

(4)Zhang K, et al. Beagle dog 90-day oral toxicity study of a novel coccidiostat - ethanamizuril. BMC Vet Res. 2020;16(1):444;

(5)Zhang K, et al. Rat two-generation reproductive toxicity and teratogenicity studies of a novel coccidiostat - Ethanamizuril. Regul Toxicol Pharmacol. 2020;113:104623;

(6)Zhang K, et al. Rat 90-day oral toxicity study of a novel coccidiostat - Ethanamizuril. Regul Toxicol Pharmacol. 2020;111:104550;

(7) Wang C, et al. Safety pharmacology assessment of Ethanamizuril, a novel triazines coccidiostat. Res Vet Sci. 2020; 132:271-278;

(8) Zhao J, et al. Two-generation reproduction and limited teratology studies of ethanamizuril fed to rats. Birth Defects Res. 2020;112(8):573-583;

(9) Shou J, et al. Tizoxanide Inhibits Inflammation in LPS-Activated RAW264.7 Macrophages via the Suppression of NF-κB and MAPK Activation. Inflammation. 2019, 42(4):1336-1349;

(10) Shou J, et al. Tizoxanide induces autophagy by inhibiting PI3K/Akt/mTOR pathway in RAW264.7 macrophage cells. Arch Pharm Res. 2020; 43(2):257-270;

(11) Wenlong Xiao, et al. Acute and 30-day oral toxicity studies of a novel coccidiostat – Ethanamizuril. Toxicol. Res., 2019, 8, 686-695;

(12) Chen P, et al. . α-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship. Bioorg Chem. 2021 Nov;116:105295.