Ying LIAO
Professional Title: Professor
Education: PhD
Supervisor Category: Doctoral Supervisor
Research Fields: Animal coronaviruses， Newcastle disease virus
1. Introduction
Prof. Liao Ying received her Ph.D. from Nanyang Technological University, Singapore, in 2007. She is currently a Professor, Ph.D. Supervisor, and Chief Scientist of the Poultry Viral Disease Team at the Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS). Prof. Liao holds several notable professional positions, including serving as a member of the 10th Poultry Disease Society of the Chinese Association of Animal Husbandry and Veterinary Medicine, a senior member of the Shanghai Agricultural System Intellectuals Association, a Guest Editorial Board Member for the Veterinary Infectious Diseases section of Frontiers in Veterinary Science, a Guest Editor for Frontiers in Microbiology, and a member of the Editorial Board for the 7th session of Journal of Virology (ISSN 1000-8721). She has received several accolades, including recognition as a Young Talent of CAAS (2015-2018), Minhang Leading Talent (2020-2022), and a Shanghai Leading Talent Reserve Candidate. Prof. Liao has dedicated her career to the study of animal coronaviruses and Newcastle disease virus. Her primary research interests encompass molecular virology, virus-host interactions, immune evasion mechanisms, pathogenesis, epidemiology, viral recombination and mutation, tissue tropism alterations, and cross-species transmission. She is also actively involved in the development of vector vaccines for poultry viral diseases using reverse genetics technology. Prof. Liao's research has been published in leading peer-reviewed journals, including PLOS Pathogens, Journal of Virology, Cell Death & Disease, Journal of Immunology, Frontiers in Microbiology, Virology, Viruses, Veterinary Research, Journal of General Virology, Oncotarget, FEBS Letters, and Biochemical and Biophysical Research Communications (BBRC). Additionally, she contributed as a co-editor to the book Poultry Respiratory Diseases.
2. Contact Information
Cell phone: +86-13331872602
Email: liaoying@shvri.ac.cn
3. Education
BSc, East China Normal University, China (1993-1997)
PhD, Nanyang Technological University, Singapore (2002-2007)
4. Professional Experience
Team leader, Avian viral infectious diseases team, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China (2021-present)
Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, China (2014-present)
Research Fellow, School of Biological Sciences, Nanyang Technological University, Singapore (2007-2009, 2010-2014)
Research Fellow, Institute of Molecular and Cell Biology, A*STAR, Singapore (2009-2010)
5. Awarded project proposals
(1) National Natural Science foundation of China (Grant No. 32372999): " Mechanism study of coronavirus targeting nucleocytoplasmic transport system to antagonize host immune response", ¥ 500,000, 2024.1-2027.12;
(2) Shanghai Natural Science Foundation project (Grant No. 23ZR1477000): " Mechanism study of coronavirus E protein promoting inflammatory response, ¥ 200,000, 2023.04-2026.03;
(3) National Key Research and Development Program (Grant No. 2021YFD180110): “Mechanism and function study of immune escape by animal coronaviruses”.¥ 2,000,000, 2022.1-2024.12;
(4) National Natural Science foundation of China (Grant No. 32172834): “The mechanism study of host translation shutoff induced by coronavirus endonuclease nsp15”, ¥ 590,000, 2022.01-2025.12;
(5) National Natural Science foundation of China (Grant No. 31772724): “Characterization of stress granules as antiviral hub for innate immune signaling”, ¥ 580,000, 2017.01-2021.12;
(6) National Key Research and Development Program (Grant No. 2017YFD0500802): “Development and application of goose and duck vaccines and immunostimulants”, ¥ 4,830,000, 2017.07-2021.06;
(7) Central Public-interest Scientific Institution Basal Research Fund (2019JB03): “Mechanistic study of delayed interferon response by infectious bronchitis virus”, ¥ 200,000, 2019.01-2021.12;
(8) Elite Youth Program of Chinese Academy of Agricultural Sciences. ¥ 3,000,000, 2015.01-2018.12;
(9) The Open Project Program of Jiangsu Key Laboratory of Zoonosis (R2007): “Coronavirus infection and prevention: Antagonizing to innate immune response by coronavirus”, ¥ 50,000, 2020.02-2022.05;
(10) Central Public-interest Scientific Institution Basal Research Fund (2017): “The entry and uncoating of infectious bronchitis virus”, ¥ 150,000, 2017.01-2017.12;
(11) Natural Science foundation of Shanghai (15ZR14496600): “The crosstalk of ER stress response and apoptosis triggered by Newcastle Disease Virus infection”, ¥ 100,000, 2015.01-2017.12.
6. Publications
(1). Xiaoqian Gong#, Shanhuan Feng#, Jiehuang Wang#, Bo Gao, Wenlian Weng, Wenxiang Xue, Hongyan Chu, Shouguo Fang, Yanmei Yuan, Yuqiang Cheng, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Min Liao, Edwin Tijhaar, Maria Forlenza*, Ying Liao*. Coronavirus endoribonuclease nsp15 induces cellular protein synthesis shutoff. Coronavirus endoribonuclease nsp15 suppresses host protein synthesis and evades PKR-eIF2α-mediated translation shutoff to ensure viral protein synthesis. Plos Pathogens . 2025. Accepted in Feb, 2025.
(2). Wenxiang Xue, Hongyan Chu, Jiehuang Wang, Yingjie Sun, Xusheng Qiu, Cuiping Song, Lei Tan, Chan Ding, Ying Liao*. Coronavirus Nucleocapsid Protein Enhances the binding of p-PKCα to RACK1: Implications for Inhibition of Nucleocytoplasmic Trafficking and Suppression of the Innate Immune Response. Plos Pathogens . 2024 Nov 27; 20(11): e1012097.
(3). Ying Liao#*，Huan Wang#, Huiyu Liao, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding.Classification, Replication and Transcription of Nidovirales . Frontiers in Microbiology. 2024 Jan 24:14:1291761.
(4). Xiao Yuan#, Xiaoman Zhang#, Huan Wang, Xiang Mao, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Ying Liao*. The Ubiquitin-Proteasome System facilitates membrane fusion and uncoating during coronavirus entry. Viruses 2023, Sep26; 15, 2001.
(5). Wenlian Weng, Qingyan Liu, Wenxiang Xue, Huan Wang, Shouguo Fang, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Ying Liao*. Characterization of the Protective Efficacy against QX Strain of a Recombinant Infectious Bronchitis Virus with H120 Backbone and QX Spike Gene. Front. Microbiol. 2022. June 17, 13：883642.
(6). Wenxiang Xue, Chan Ding, Kun Qian, Ying Liao. The interplay between coronavirus and type I IFN response. Frontiers in Microbiology. 2022. March 04. 12：805472.
(7). Bo Gao#, Xiaoqian Gong#, Shouguo Fang, Wenlian Weng, Huan Wang, Hongyan Chu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Maria Forlenza, Chan Ding, Ying Liao*. Inhibition of Anti-viral Stress Granule Formation by coronavirus endoribonuclease nsp15 Ensures Efficient Virus Replication. Plos Pathogens . 2021. Feb 26;17(2):e1008690.
(8). Huan Wang, Dingxiang Liu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Liao Ying*.Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis. Veterinary Research. 2021. Jan 11;52(1):7.
(9). Yanrong Li#, Weiyu Jiang, Qiaona Niu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao*#, Chan Ding*eIF2α-CHOP-BCl2/JNK and IRE1α-XBP1/JNK Signaling Promote Apoptosis and Inflammation and Support the proliferation of Newcastle Disease Virus.Cell death & Disease. 2019. Nov 26;10 (12):891.
(10). Shichong Han#, Lejiao Mao#, Ying Liao#, Shiqi Sun#, Zhihui Zhang, Yaxia Mo, Haiyun Liu, Xiaoying Zhi, Shunmei Lin,Ho Seong Seo, Huichen Guo.Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α-RIG-I Antiviral Signaling. Journal of Immunology. 2019 Jul 15;203(2):429-440.
(11). Wang H, Yuan X, Sun Y, Mao X, Meng C, Tan L, Song C, Qiu X, Ding C, Liao Y *.Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system. Virology. 2019; Feb528:118-136.
(12). Fan XX#, Han SC#, YanD, GaoY, WeiYQ, LiuXT, Liao Y*, Guo HC*, Sun SQ*.Foot-and–mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro. Cell Death & Disease. 2017. Jan 19;8(1):e2561.
(13). Liao Y#*, Wang HX#, Mao X, Fang H, Wang H, Li Y, Sun Y, Meng C, Tan L, Song C, Qiu X, Ding C*.RIP1 is a central signaling protein in regulation of TNF-α/TRAIL mediated apoptosis and necroptosis during Newcastle disease virus infection. Oncotarget. 2017. 8 (26): 43201-43217.
(14). Wang X, Wang R, Luo M, Li C, Wang HX, Huan CC, Qu YR,Liao Y*, Mao X*. (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017 May16;8(20):33197-33213.
(15). Fung TS#, LiaoY*，LiuDX*.Regulation of Stress Responses and Translational Control by Coronavirus. Viruses. 2016 Jul 4;8(7). pii: E184.
(16). Liao Y#*, Gu F#, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C*. 2016.Regulation of de novo Translation of Host Cells by Manipulation of PERK/PKR and GADD34-PP1 Activity during Newcastle Disease Virus Infection. J Gen Virol. 2016 Apr;97(4):867-79.
(17). Liao Y#, Zhang SM, Neo TL, Tam JP*. 2015.Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike protein. Biochemistry. 54(9):1819-30.
(18). Liao Y#, Fung TS, Huang M, Fang SG, Zhong Y, Liu DX*. 2013.Up-regulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway. 2013. J Virol. 87(14):8124-34.
(19). Liao Y#, Wang X, Huang M, Tam JP, Liu DX. 2011*.Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus. Virology. 420 (2):106-16.
(20). Wang, X.X.#, Liao,Y.#, Yap PL, Png KJ, Tam JP, Liu DX.Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells. J Virol. 2009. 83(23):12462-72.
(21). Liao, Y., Yuan, Q., Torres, J., Tam, J. P., and Liu, D. X. 2006.Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein. Virology. 349:264-275.
(22). Liao, Y., Lescar, J., Tam, P. J., and Liu, D. X. 2004.Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability. BBRC. 325: 374-380.
(23). Liao, Y., Tam, J. P., and Liu, D. X. 2005.Viroporin activity of SARS-CoV E protein. Adv. Exp. Med. Biol.199-202.
7. Patent
A cell line expressing furin protein and its application in the culture of avian infectious bronchitis virus. Ying Liao, Ding Shan, Wang Huan, Sun Yingjie, Tan Lei, Meng Chunchun, Song Cuiping, Qiu Xusheng, and Liu Weiwei. Patent No.: zl 202011211170.6, authorization notice No.: cn 112342244b, authorization announcement date: June 30, 2023.