Jianchao WEI

Professional Title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research Fields: The development of innovative vaccines and detection technology for animal arboviruses,including Japanese Encephalitis Virus,and African Swine Fever Virus.Research on the pathogenic mechanisms, evolutionary rules, and interaction between viral proteins and host cellular proteins.

1. Introduction

Jianchao Wei is a professor and a doctoral mentor in Preventive Veterinary Medicine, and received Ph.D. from Nanjing Agricultural University in 2010, and is currently the deputy director of the Achievement Transformation Department (Material Procurement Platform Management Department).

He is currently on the editorial board of Frontiers in Microbiology, Viruses.. He is also the master mentor of Yangtze University, the deputy director of Branch of Veterinary Public Health, Chinese Veterinary Medical Association,the council member of Shanghai Veterinary Immunology Association.He has been long engaged in the development of innovative vaccines and detection technology for animal arboviruses,including Japanese Encephalitis Virus,and African Swine Fever Virus.Research on the pathogenic mechanisms, evolutionary rules, and interaction between viral proteins and host cellular proteins.He has presided over and participated in 20 projects including National Natural Science Foundation, key research and development program, etc. He has trained 7 masters. He has published 90 high-quality papers including 80 SCI, and 3 textbooks and works, and 15 authorized patents.

2. Contact Information

Tel：021-34293430

Email：jianchaowei@shvri.ac.cn

3. Selected Papers

[1] Li, C., Di, D., Huang, H., Wang, X., Xia, Q., Ma, X., Liu, K., Li, B., Shao, D., Qiu, Y., Li, Z., Wei, J*., Ma, Z*. NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings.  PLoS Pathog . 2020 Sep 3;16(9):e1008773.

[2] Ma X, Xia Q, Liu K, Wu Z, Li C, Xiao C, Dong N, Hameed M, Anwar MN, Li Z, Shao D, Li B, Qiu Y, Wei J*, Ma Z*. Palmitoylation at Residue C221 of Japanese Encephalitis Virus NS2A Protein Contributes to Viral Replication Efficiency and Virulence. J Virol. 2023 Jun 29;97(6):e0038223.

[3] Xia Q, Zhang Y, Yang Y, Ma X, Guan Z, Zhang J, Li Z, Liu K, Li B, Shao D, Qiu Y, Wei J*, Ma Z*. Virulence and Cross-Protection Conferred by an Attenuated Genotype I-Based Chimeric Japanese Encephalitis Virus Strain Harboring the E Protein of Genotype V in Mice. Microbiol Spectr. 2022 Dec 21;10(6):e0199022. doi: 10.1128/spectrum.01990-22. Epub 2022 Oct 27. PMID: 36301111; PMCID: PMC9769820.

[4] Wei, J., Hameed, M., Wang, X., Zhang, J., Guo, S., Anwar, MN., Pang, L., Liu, K., Li, B., Shao, D., Qiu, Y., Zhong, D*., Zhou, B*., Ma, Z*. Antiviral activity of phage display-selected peptides against Japanese encephalitis virus infection in vitro and in vivo.  Antiviral Res . 2020 Feb;174:104673.

[5] Yang Y, Xia Q, Zhou L, Zhang Y, Guan Z, Zhang J, Li Z, Liu K, Li B, Shao D, Qiu Y, Ma Z*, Wei J*. B602L-Fc fusion protein enhances the immunogenicity of the B602L protein of the African swine fever virus. Front Immunol. 2023 Jun 22;14:1186299.

[6] Anwar, MN., Wang, X., Hameed, M., Wahaab, A., Li, C., Sharma, M., Pang, L., Malik, MI., Liu, K., Li, B., Qiu, Y., Wei, J*., Ma, Z*. Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain.  Viruses . 2020 May 16;12(5):552.

[7] Hameed M, Wahaab A, Shan T, Wang X, Khan S, Di D, Xiqian L, Zhang JJ, Anwar MN, Nawaz M, Li B, Liu K, Shao D, Qiu Y, Wei J*, Ma Z*. A Metagenomic Analysis of Mosquito Virome Collected From Different Animal Farms at Yunnan-Myanmar Border of China. Front Microbiol. 2021 Feb 8;11:591478.

[8] Hameed, M., Khan, S., Xu, J., Zhang, J., Wang, X., Di, D., Chen, Z., Naveed Anwar, M., Wahaab, A., Ma, X., Nawaz, M., Liu, K., Li, B., Shao, D., Qiu, Y., Wei, J*., Ma, Z*. Detection of Japanese encephalitis virus in mosquitoes from Xinjiang during next-generation sequencing arboviral surveillance.  Transbound Emerg Dis . 2021 Mar;68(2):467-476.

[9] Wei, J., Wang, X., Zhang, J., Guo, S., Pang, L., Shi, K., Liu, K., Shao, D., Qiu, Y., Liu, L., Widén, F., Li, B*., Ma, Z*. Partial cross-protection between Japanese encephalitis virus genotype I and III in mice.  PLoS Negl Trop Dis . 2019 Aug 2;13(8):e0007601.

[10] Anwar MN, Jiang C, Di D, Zhang J, Guo S, Wang X, Hameed M, Wahaab A, Shao D, Li Z, Liu K, Li B, Qiu Y, Ma Z*, Wei J*. A Novel Recombinant Virus-Like Particles Displaying B and T Cell Epitopes of Japanese Encephalitis Virus Offers Protective Immunity in Mice and Guinea Pigs. Vaccines (Basel). 2021 Sep 2;9(9):980.

[11] Anwar MN, Guo S, Xin W, Hameed M, Wahaab A, Ma X, Khan AU, Rahman SU, Shao D, Li Z, Liu K, Li B, Qiu Y, Ma Z*, Wei J*. Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes. Virus Res. 2021 Jan 15;292:198256.

4. Patents and Standards

[1] The invention relates to a method for identifying genotype Ⅰ, Ⅲ, Ⅴ JE virus and Getavirus and its kit. 2023.01.24,Chinese patent number: ZL 202111478453.1

[2] The invention relates to a heterozygous peptide used for food preservation and its gene expression method in the expression system of Saccharomyces cerevisiae.2022.08.19, Chinese patent number:CN202110336260.6

[3] siRNA inhibition of influenza virus related genes and its application, 2018.8.31, Chinese patent number: ZL201610139670.0

[4] A recombinant vector and its application in the preparation or screening of anti-influenza drugs, 2019.4.2, Chinese patent number:  ZL201610139667.9

[5] A recombinant vector and its application in the preparation or screening of anti-influenza drugs, 2019.4.2, Chinese patent number: ZL201610141142.9

[6] A class of anti-Japanese encephalitis virus composition and its application, 2018.10.23, Chinese patent number: ZL201510391532.7

[7] Real-time fluorescent quantitative PCR method and kit for one-step detection of Z/S subtype Ebola virus, 2017.3.22, Chinese patent number:  ZL201110312855.4

[8] A fluorescent quantitative PCR method for detection of Ebola virus and its primer and kit, 2016.06.08, Chinese patent number: ZL201110312915.2

[9] siRNA inhibition of influenza virus related genes and its application, 2018.2.13, Chinese patent number: ZL201210019712.9

[10] Host-associated genes inhibiting influenza virus replication and screening methods and applications, 2018.4.6, Chinese patent number:  ZL201210019736.4

[11] A class of anti-Japanese encephalitis virus composition and its application, 2015.9.16, China, ZL201110329906.4