Qinghai HU

Professional title: Professor

Education: PhD

Supervisor Category: Doctoral Supervisor

Research direction: Molecular pathogenesis and new vaccines of animal bacterial diseases.

1. Introduction

Qinghai Hu, Ph.D., Professor, doctoral supervisor. He mainly engages in research on the molecular pathogenesis and novel vaccines of animal pathogenic bacteria (such as  Riemerella anatipestifer ), as well as the rapid detection technology of animal pathogens. He hosted more than 10 national or provincial / ministerial level projects, including the National Natural Science Foundation of China, the sub projects of National Key Research and Development Program of China, and the Shanghai Natural Science Foundation, etc. As the first or corresponding author, he published over 70 papers, including in "Journal of Bacteriology", "Frontiers in Microbiolgy", "Veterinary Microbiology", etc., and obtained 6 patents. He has received three provincial and ministerial level scientific and technological achievement awards. Since 2008, 32 graduate students have graduated under his supervision.

2. Contact Information

Cell phone: 18930251729

Email: hqh@shvri.ac.cn.

3. Representative Works

[1] Jialing Wang, Zuocheng Zou, Mengmeng Hu, Xinggen Shan, Ying Zhang, Yiqin Miao, XiaoYing Zhang, Nazrul Islam, Qinghai Hu*.  Riemerella anatipestifer  UvrC is required for iron utilization, biofilm formation and virulence, Avian Pathology, 2024, doi: 10.1080/03079457.2024.2317431.

[2] Xiaoli Du; Jialing Wang; Xinggen Shan; Zhiqun Hu; Yongheng Gao; Qinghai Hu*; DEAD Box Protein DhR1 Is a Global Regulator Involved in the Bacterial Fitness and Virulence of  Riemerella anatipestifer , Journal of Bacteriology, 2023, 205(1): e0034122.

[3] Jialing Wang; Yan Chen; Xiaohua He; Xiaoli Du; Yongheng Gao; Xinggen Shan; Zhiqun Hu; Qinghai Hu*; PaR1 secreted by the type IX secretion system is a protective antigen of  Riemerella anatipestifer , Frontiers in Microbiology, 2023, 13: 1082712.

[4] Bingqing Sun; Yafei Xue; Xiaoli Du; Xiaohua He; Zuocheng Zou; Xiangqiang Tian; Zhonghao Hu; Haoyang Liu; Nazrul Islam; Qinghai Hu*; Identification of genetic determinants of hemolytic activity of  Riemerella anatipestifer  using random transposon mutagenesis, Veterinary Research,2021, 52: 19.

[5] Minjie Tao; Jialing Wang; Ke Li; Yafei Xue; Xinxin Xu; Xiaoli Du; Xiaohua He; Xiangqiang Tian; Zuocheng Zou; Zhonghao Hu; Nazrul Islam; Qinghai Hu*; Development of signature-tagged mutagenesis in  Riemerella anatipestifer  to identify genes essential for survival and pathogenesis, Veterinary Microbiology, 2020, 250: 108857.

[6] Xinxin Xu; Yaohui Xu; Shuang Miao; Pan Jiang; Junsheng Cui; Yanshan Gong 1; Panpan Tan; Xiaoli Du; Nazrul Islam; Qinghai Hu*; Evaluation of the protective immunity of  Riemerella anatipestifer  OmpA., Applied Microbiology and Biotechnology, 2020, 104(3): 1273-1281.

[7] Xintao Ni, Pan Jiang, Linlin Xing, Changcan Ou, Hui Yu, Jingjing Qi, Bingqing Sun, Junsheng Cui, Guijun Wang*, Qinghai Hu*. Genome-wide mining of potential virulence-associated genes in  Riemerella anatipestifer  using random transposon mutagenesis, Veterinary Microbiology, 2016, 189:52-58.

[8] Tao Zheng, Pan Jiang, Bo Cao, Qiuxiang Cheng, Lingxin Kong, Xiaoqing Zheng, Qinghai Hu*, and Delin You*. DndEi exhibits helicase activity essential for DNA phosphorothioate modification and ATPase activity strongly stimulated by DNA substrate with a GAAC/GTTC motif. Journal of Biological Chemistry, 2016, 291(3):1492-500.

[9] Shuang Miao, Linlin Xing, Jingjing Qi, Hui Yu, Pan Jiang, Bingqing Sun, Junsheng Cui, Changcan Ou, Qinghai Hu*. Roles of the TonB1 and TonB2 proteins in haemin iron acquisition and virulence in  Riemerella anatipestifer . Microbiology. 2015, 161(8):1592-1599.

[10] Linlin Xing, Hui Yu, Jingjing Qi, Pan Jiang, Bingqing Sun, Junsheng Cui, Changcan Ou, Weishan Chang*, Qinghai Hu*.  ErmF and ereD are responsible for erythromycin resistance in  Riemerella anatipestifer , PLoS ONE, 2015, 10(6): e0131078.  

4. Patents

[1] A shuttle expression vector of  Escherichia coli-Riemerella anatipestifer  and its construction method and application, Chinese patent number: ZL201210100921.6

[2] A multiplex PCR detection kit and detection method for common bacteria from duck sources, Chinese patent number: ZL 201010290683.0.

[3] A chicken specific CpG ODN and its application, Chinese patent number: ZL200610038448.8

5. Rewards

[1] Research on the Prevention and Control Methods of  Riemerella anatipestifer  infection, the third prize of Science and Technology Progress Award of Jiangsu Province, 2002. (Ranked 1^st)

[2] Research and application of virulence factors and diagnostic techniques of  Riemerella anatipestifer , the second prize of the Science and Technology Progress Award of the Chinese Academy of Agricultural Sciences, 2014. (Ranked 4^th)

[3] Non resistant screening of DNA vaccine vectors and Salmonella delivery systems, the second prize of Technology Invention Award of the Ministry of Education, 2009. (Ranked 4^th)

[4] Leading Talent in Minhang, Shanghai, Qinghai Hu, 2013.