Ning KONG

Professional Title: Associate Professor

Education: PhD

Supervisor Category: Master Supervisor

Research Fields: Porcine Epidemic diarrhea virus pathogenicity and host immune mechanism research

1. Introduction

Dr. Kong Ning, Associate Researcher, Master supervisor, Research assistant of Porcine Viral Reproductive Disorder Disease Prevention and Control Technology Research team. Engaged in research on the pathogenicity and host immune mechanism of porcine epidemic diarrhea virus for a long time. Presided over 1 National Natural Science Foundation Youth Fund project, 1 Youth Innovation Task of Chinese Academy of Agricultural Sciences, 1 Shanghai Natural Science Foundation, and 1 China Postdoctoral Science Fund. Published more than 40 papers in Autophagy, Journal of Virology, Microbiology Spectrum and other journals, including 26 SCI papers and 1 patent.

2. Contact Information

Office phone: 021-34293773

Email: kongning@shvri.ac.cn

3. Representative Writing

(1) Ning Kong#, Tongling Shan#, Hua Wang, Yajuan Jiao, Yewen Zuo, Liwei Li, Wu Tong, Lingxue Yu, Yifeng Jiang, Yanjun Zhou, Guoxin Li, Fei Gao, Hai Yu, Hao Zheng, Guangzhi Tong. BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy. Autophagy 2020; 16:1737-52. IF=""16.016

(2) Dage Sun#, Ning Kong#, Sujie Dong#, Xiaoyong Chen, Wenzhen Qin, Hua Wang, Yajuan Jiao, Huanjie Zhai, Liwei Li, Fei Gao, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong, Tongling Shan. 2AB protein of Senecavirus A antagonizes selective autophagy and type I interferon production by degrading LC3 and MARCHF8. Autophagy 2021. IF=""13.391

(3) Yajuan Jiao#, Ning Kong#, Hua Wang#, Dage Sun#, Sujie Dong, Xiaoyong Chen, Hao Zheng, Wu Tong, Hai Yu, Lingxue Yu, Yaowei Huang, Huan Wang, Baokun Sui, Ling Zhao, Ying Liao, Wen Zhang, Guangzhi Tong, Tongling Shan. PABPC4 broadly inhibits coronavirus replication by degrading nucleocapsid protein through selective autophagy. Microbiology Spectrum, 2021, 9:e00908-21. IF=""9.043

(4) Hua Wang#, Ning Kong#, Yajuan Jiao#, Sujie Dong#, Dage Sun, Xiaoyong Chen, Hao Zheng, Wu Tong, Hai Yu, Lingxue Yu, Wen Zhang, Guangzhi Tong, Tongling Shan. EGR1 suppresses porcine epidemic diarrhea virus replication by regulating IRAV to degrade viral nucleocapsid protein. Journal of Virology, 2021, 95:e00645-21. IF=""6.549

(5) Sujie Dong#, Ning Kong#, Yu Zhang#, Youwen Li#, Dage Sun, Wenzhen Qin, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong*, Tongling Shan*. TARDBP inhibits porcine epidemic diarrhea virus replication by degrading viral nucleocapsid protein and activating type I IFN signaling. Journal of Virology. 2022. IF=""6.549

(6) Sujie Dong#, Ning Kong#, Chunmei Wang#, Youwen Li, Dage Sun, Wenzhen Qin, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Wu Tong, Hai Yu, Wen Zhang, Guangzhi Tong*, Tongling Shan*. FUBP3 degrades the PEDV nucleocapsid protein and induces the production of type I interferon. Journal of Virology. 2022. IF=""6.549

(7) Wenzhen Qin#, Ning Kong#, Yu Zhang#, Sujie Dong, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Changlong Liu, Lingxue Yu, Hao Zheng, Hai Yu, Wen Zhang, Guangzhi Tong, Daoliang Lan*, Wu Tong*, Tongling Shan*. Nuclear ribonucleoprotein RALY targets virus nucleocapsid protein and induces autophagy to restrict porcine epidemic diarrhea virus replication. Journal of Biological Chemistry. 2022. IF=""5.486

(8) Kong Ning#, Meng Qiong#, Jiao Yajuan#, Wu Yongguang, Zuo Yewen, Wang Hua, Sun Dage, Dong Sujie, Zhai Huanjie, Tong Wu, Zheng Hao, Yu Hai, Tong Guangzhi, Xu Yongjie*, Shan Tongling*. Identification of a novel B-cell epitope in the spike protein of porcine epidemic diarrhea virus. Virology Journal, 2020, 17(1): 0-46. IF=""4.099

4. Patent standard

“Monoclonal antibody against Porcine Epidemic diarrhea virus N protein and its application”, Authorization announcement date: March 29, 2019, National Invention Patent, patent number: ZL201410384478.9