Liwei LI

Professional Title: Associate Professor

Education: PhD

Mentor category: Master Supervisor

Research direction: Pathogenic mechanisms of porcine reproductive and respiratory syndrome virus

1. Introduction

Liwei Li, Ph.D., Associate Researcher, Master's Supervisor. Engaged in long-term research on the pathogenic variation mechanisms of important viral diseases in livestock, such as porcine reproductive and respiratory syndrome virus and African swine fever virus. Hosted or participated several projects, including the National Natural Science Foundation of China, National Key Research and Development Program of China, Shanghai Agriculture Applied Technology Development Program, and Innovation Program of Chinese Academy of Agricultural Sciences. Published more than 20 papers in domestic and foreign academic journals such as Journal of Virology, Veterinary Microbiology, and Virus Research.

2. Contact Information

Phone: +86 18817555086

Email: liliwei@shvri.ac.cn

3. Publications

[1]. Li L, Bai Y, Zhou Y, Jiang Y, Tong W, Li G, Zheng H, Gao F*, Tong G*. PSMB1 inhibits the replication of porcine reproductive and respiratory syndrome virus by recruiting NBR1 to degrade nonstructural protein 12 by autophagy. Journal of Virology. 2023, 97(1): e0166022.

[2]. Li L, Qiao S, Liu J, Zhou Y, Tong W, Dong S, Liu C, Jiang Y, Guo Z, Zheng H, Zhao R, Tong G, Li G*, Gao F*. A highly efficient indirect ELISA and monoclonal antibody established against African swine fever virus pK205R. Frontiers in Immunology. 2023, 13:1103166.

[3]. Zhang Y, Kong N, Ti J, Cao D, Sui Z, Ge A, Pan L, Zhao K, Zhou Y, Tong G, Li L*, Gao F*. BST2 negatively regulates porcine reproductive and respiratory syndrome virus replication by restricting the expression of viral proteins. Virus Research. 2023, 334:199181.

[4]. Li L, Chen J, Cao Z, Cao Y, Guo Z, Tong W, Zhou Y, Li G, Jiang Y, Liu C, Yu L, Qiao S, Liu J, Tong G*, Gao F*. Recombinant bivalent live vectored vaccine against classical swine fever and HP-PRRS revealed adequate heterogeneous protection against NADC30-Like strain. Frontiers in Microbiology. 2022, 12: 822749.

[5]. Li L, Qiao S, Li G, Tong W, Dong S, Liu J, Guo Z, Zheng H, Zhao R, Tong G, Zhou Y*, Gao F*. The Indirect ELISA and Monoclonal Antibody against African Swine Fever Virus p17 Revealed Efficient Detection and Application Prospects. Viruses. 2022, 15(1):50.

[6]. Li L, Zhao K, Gao F, Jiang Y, Shan T, Tong W, Zheng H, Yu L, Li G, Ma Z, Tong G*. Restriction of porcine reproductive and respiratory syndrome virus replication by galectin-1. Veterinary Microbiology, 2019, 235:310-318.

[7]. Li L, Du N, Chen J, Zhang K, Tong W, Zheng H, Zhao R, Tong G, Gao F*. Establishment and Application of a Quantitative PCR Method for E248R Gene of African Swine Fever Virus. Veterinary Sciences, 2022, 9(8):417.

[8]. Li L, Zhou Y, Jiang Y, Gao F, Shan T, Zhao K, Zhang Y, Li L, Tong G*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91

[9]. Li L, Gao F, Zheng H, Jiang Y, Tong W, Zhou Y, Tong G*. Utilizing Host Endogenous microRNAs to Negatively Regulate the Replication of Porcine Reproductive and Respiratory Syndrome Virus in MARC-145 cells. PLOS ONE, 2018, 13(7):e0200029.

[10]. Liu X, Li L, Gao F, Jiang Y, Yuan W, Li G, Yu L, Zhou Y, Tong G, Zhao K*. cGAS restricts PRRSV replication by sensing the mtDNA to increase the cGAMP activity. Frontiers in Immunology, 2022, 13:887054.

11. Cao Z, Chen J, Li L, Liu J, Tong W, Zhou Y, Tong G, Wang G*, Gao F*. A rescued NADC30-like virus by reverse genetic manipulation exhibits moderate virulence and a promising application perspective. Virus Research, 2022, 316:198801.

[12]. Bai Y, Li L, Shan T, Zhang Y, Chen X, Gao F, Jiang Y, Zhou Y, Li G, Yu L, Kong N, Ma Z, Tong G*. Proteasomal degradation of nonstructural protein 12 by RNF114 suppresses porcine reproductive and respiratory syndrome virus replication. Veterinary Microbiology, 2020, 246:108746.

[13]. Zhao K, Li L, Jiang Y, Gao F, Zhang Y, Zhao W, Li G, Yu L, Zhou Y, Tong G*. Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination. Veterinary Microbiology, 2019, 233:140-146.

[14]. Zhao K, Li L, Zhang Y, Jiang Y, Gao F, Li G, Yu L, Zhao W, Shan T, Zhou Y, Tong G*. MOV10 inhibits replication of porcine reproductive and respiratory syndrome virus by retaining viral nucleocapsid protein in the cytoplasm of Marc-145 cells. Biochemical and Biophysical Research Communications, 2018, 504:157-163