Chunmei WANG

Professional Title: Associate Professor

Education: PhD

Supervisor Category: Master Supervisor

Research Fields: Veterinary Pharmacology，Innovation in  Animal Drug Development

1. Introduction

Chunmei Wang, female, Doctor, Associate researcher, master supervisor, research backbone of animal anti-infective drugs and microbial resistance team of Shanghai Veterinary Institute, Chinese Academy of Agricultural Sciences. I am mainly engaged in the screening of novel antibacterial drug candidates and pharmacokinetic study. Get funding from the National Natural Science Foundation, China Postdoctoral Foundation and Shanghai Natural Science Foundation. Published several papers in the journal of  Bioorganic and Medicinal Chemistry ， Microbiology Spectrum ， Parasites Vectors  and other journals, and Participated in writing 2 monographs (translations). Obtained 11 authorized patents, obtained 2 registration certificates of class 1 innovative drugs.

2. Contact information

Tel：021-34293396

E-mail：wangchunmei@shvri.ac.cn

3. Representative works

[1]. Lu Y, Guan T, Wang S, Zhou C, Wang M, Wang X, Zhang K, Han X, Lin J, Tang Q, Wang C＃, Zhou W＃. Novel xanthone antibacterials: Semi-synthesis, biological evaluation, and the action mechanisms.  Bioorg Med Chem . 2023 Apr 1;83:117232. doi: 10.1016/j.bmc.2023.117232. Epub 2023 Mar 8. PMID: 36940608.(Co-corresponding author)

[2]. Qin W※, Kong N※, Zhang Y※, Wang C※, Dong S, Zhai H, Zhai X, Yang X, Ye C, Ye M, Tong W, Liu C, Yu L, Zheng H, Yu H, Zhang W, Lan D, Tong G, Shan T. PTBP1 suppresses porcine epidemic diarrhea virus replication via inducing protein degradation and IFN production.  J Biol Chem . 2023 Aug;299(8):104987. doi: 10.1016/j.jbc.2023.104987. Epub 2023 Jun 29. PMID: 37392846; PMCID: PMC10407749.(Co-first authorship)

[3]. Zhai X※, Kong N※, Wang C※, Qin W, Dong S, Zhai H, Yang X, Ye C, Ye M, Li G, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Tong G, Shan T. PRPF19 Limits Porcine Epidemic Diarrhea Virus Replication through Targeting and Degrading Viral Capsid Protein.  J Virol . 2023 Jan 31;97(1):e0161422. doi: 10.1128/jvi.01614-22. Epub 2022 Dec 21. PMID: 36541804; PMCID: PMC9888217.(Co-first authorship)

[4]. Lu J※, Yang S※, Wang C※, Wang H, Gong G, Xi Y, Pan J, Wang X, Zeng J, Zhang J, Li P, Shen Q, Shan T, Zhang W. Gut Virome of the World's Highest-Elevation Lizard Species (Phrynocephalus erythrurus and Phrynocephalus theobaldi) Reveals Versatile Commensal Viruses. Microbiol Spectr. 2022 Feb 23;10(1):e0187221. doi: 10.1128/spectrum.01872-21. Epub 2022 Feb 23. PMID: 35196818; PMCID: PMC8865479.(Co-first authorship)

[5]. Qin W※, Kong N※, Wang C※, Dong S, Zhai H, Zhai X, Yang X, Ye C, Ye M, Tong W, Liu C, Yu L, Zheng H, Yu H, Lan D, Zhang W, Tong G, Shan T. hnRNP K Degrades Viral Nucleocapsid Protein and Induces Type I IFN Production to Inhibit Porcine Epidemic Diarrhea Virus Replication. J Virol. 2022 Nov 1:e0155522. doi: 10.1128/jvi.01555-22. Epub ahead of print. PMID: 36317879.(Co-first authorship)

[6]. Cheng P※, Wang C※, Zhang L，Fei  C, Liu Y, Wang M, Zhang K, Wang X, Gu F, Xue F, Label-free quantitative proteomic analysis of ethanamizuril-resistant versus -sensitive strains of Eimeria tenella. Parasites Vectors 15, 319 (2022). https://doi.org/10.1186/s13071-022-05412-6.(Co-first authorship)

[7]. Dong S※, Kong N※, Wang C※, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T. FUBP3 Degrades the Porcine Epidemic Diarrhea Virus Nucleocapsid Protein and Induces the Production of Type I Interferon. J Virol. 2022 Jul 13;96(13):e0061822. doi: 10.1128/jvi.00618-22.(Co-first authorship)

[8]. Zhang Y※, Wang C※, Zhu C, Ye W, Gu Q, Shu C, Feng X, Chen X, Zhang W, Shan T. Redondoviridae infection regulates circRNAome in periodontitis. J Med Virol. 2022 Jun;94(6):2537-2547. doi: 10.1002/jmv.27624. Epub 2022 Feb 3. PMID: 35075668.(Co-first authorship)

[9]. Zhang Y※, Wang C※, Feng X, Chen X, Zhang W, Redondoviridae and periodontitis: a case–control study and identification of five novel redondoviruses from periodontal tissues, Virus Evolution, 2021,7(1), January veab033,  https://doi.org/10.1093/ve/veab033.(Co-first authorship)

[10]. Cheng P※, Wang C※, Lin X, Zhang L, Fei C, Zhang K, Zhao J, Lei N, Liu L, Mu S, Wang X, Wang M, Zheng W, Liu Y, Guo C, Xue F＃. Pharmacokinetics of a novel triazine ethanamizuril in rats and broiler chickens. Res Vet Sci. 2018 Apr;117:99-103. doi: 10.1016/j.rvsc.2017.11.001. Epub 2017 Nov 10. PMID: 29220724.(Co-first authorship)

[11]. Wang C, Liu Y, Zheng H, Li Y, He J, Wang X, Wang M, Zhang L, Xue F, Zhang K. Safety pharmacology assessment of Ethanamizuril, a novel triazines coccidiostat. Res Vet Sci. 2020 Oct;132:271-278. doi: 10.1016/j.rvsc.2020.07.003. Epub 2020 Jul 15. PMID: 32693252.

[12]. Lu J※; Yang S※; Wang C※; Wang H; Gong G; Xi Y; Pan J; Wang X; Zeng J; Zhang J; Li P; Shen Q; Shan T; Zhang W; Gut Virome of the World's Highest-Elevation Lizard Species (Phrynocephalus erythrurus and Phrynocephalus theobaldi) Reveals Versatile Commensal Viruses, Microbiol Spectr, 2022, 01872-21. (Co-first authorship)

[13]. Yu Zhang※,  Chunmei Wang※,  Xiping Feng,  Xi Chen,  Wen Zhang. Redondoviridae and periodontitis: a case–control study and identification of five novel redondoviruses from periodontal tissues. Virus Evolution, Volume 7, Issue 1, 2021, veab033.(Co-first authorship)

[14]. Chen W, Zhou C, Chen J, Wang M, Zhou F, Wang C#, Zhang X#, Zhou W#. Design and synthesis of epigallocatechin (EGC) analogs selective to inhibit α-amylase over α-glucosidases via the incorporation of caffeine acid and its derivatives. Bioorg Chem. 2022 Feb;119:105515. doi: 10.1016/j.bioorg.2021.105515. Epub 2021 Dec 5. PMID: 34896919. (Co-corresponding author)

4. Patents

[1]. The Preparation and antibacterial use of Oxanthrone esters and carbohydrate derivatives,  2022-11-01, China, CN115260146A.

[2]. An anticoccidian disinfectant, 2020-06-16, China, CN111280179A.

[3]. Rapid detection method for different species of Coccidia, 2019-10-11, China, CN110317892A.

[4]. Application of Tizolide and Nitazolide in the preparation of anti-inflammatory drugs, 2019-07-19, China, CN110025621A.

[5]. Formulation and preparation of an oral drug solution with anticoccidia effect, 2019-10-01, China, CN110292561A.

[6]. Application of quinoxolin-1, 4-dioxides in anti-Toxoplasma infection, 2019-09-24, China, CN110269859A.

[7]. Application of Tizolide and Nitazolide in the preparation of autophagy inducers, 2019-7-12, China, CN109999045A.

[8]. Dafloxacin mesylate microsphere preparation for livestock and poultry and preparation method thereof. 2009-04-22. China, CN101411689.

[9]. A preparation method for p-nitro-o-cresol, 2016-06-22. China, CN105693522A.

[10]. Chinese Herbal Compound composition for treating Piglet dysentery, 2015-10-21. China, CN104983861A.

[11]. A triazine compound amorphous substance and its preparation method and use, 2015-05-13. China, CN104610182A.

5. New veterinary medicine certificates

[1]. Class 1 of National new veterinary drug, Ethanamizuril, (2020) New Veterinary Drug License No. 54;

[2]. Class 1 of National new veterinary drugs, Ethanamizuril solution, (2020) New veterinary drug License No. 55.