Jie ZHU

Professional Title: Associate Professor

Education: PhD

Supervisor Category: Master Supervisor

Research Fields: Basic and applied research on animal caliciviruses and feline coronaviruses

1. Introduction

ZHU Jie, Ph.D., Associate Professor, Master supervisor, main expert of the Biosafety Risk Warning and Prevention and Control Technology for Companion Animals Team;  Outstanding talents of Chunshen Pyramid in Minhang District of Shanghai, Young member of the Branch of Animal Infectious Diseases of Chinese Association of Animal Husbandry and Veterinary Medicine; Member of Editorial Board of  BMC Veterinary Research ;  Zoonoses , Member of youth Editorial Board of  Animal Research And One Health ,  Animals and Zoonoses  and other academic journals. He presided National Key Research and Development Program of China project, Chinese Natural Sciences Foundation project, Natural Science Foundation of Shanghai project, Shanghai Sailing Program,etc. He has published 12 papers as first author in top journals such as  PLoS pathogens ,  The Journal of Biological Chemistry ,  Veterinary microbiology ,  Virologica Sinica  and handed 3 national invention patents.

2. Contact Information 

Tel: 86-021-54225512

Email: zj121@shvri.ac.cn

3. Research Interests

Dr. Zhu majority focus on basic and applied research on Rabbit hemorrhagic disease virus (RHDV), Feline calicivirus (FCV), and Feline coronavirus (FCoV).

(1)  Study on the mechanism of virus-host interaction:

Firstly, the concept of “heterogeneous ribosome” was introduced to study the molecular mechanism by which caliciviruses hijack and modify the host ribosome to translate viral proteins.

Secondly, multi-omics methods were used to study the molecular mechanisms of changes in pathogenicity of RHDV and RHDV2, and of changes in pathogenicity of FCV and VSD-FCV from the perspective of viral invasion and replication.

Thirdly, the role of host membrane proteins in feline coronavirus invasion was studied to solve the problem of feline coronavirus proliferation in vitro.

（2）Research and development of new vaccines and therapeutic biologics:

Firstly, establish a platform for the development of circular RNA vaccine for cats.

Secondly, develop bivalent genetic engineering vaccines against RHDV and RHDV2.

Thirdly, research and development of therapeutic biological products such as interferon and yolk antibody for cats.

4. Representative Papers

(1). Zhu J, Miao Q, Tang J, Wang X, Dong D, et al. (2018) Nucleolin mediates the internalization of rabbit hemorrhagic disease virus through clathrin-dependent endocytosis.  PLoS Pathogens  14: e1007383. (IF: 6.218, Q1)

(2).  Zhu J, Miao Q, Tan Y, Guo H, Liu T, et al. (2017) Inclusion of an Arg-Gly-Asp receptor-recognition motif into the capsid protein of rabbit hemorrhagic disease virus enables culture of the virus in vitro.  J Biol Chem  292: 8605-8615. (IF: 4.106, Q2)

(3). Zhu J, Miao Q, Guo H, Tang A, et al. (2022) Nucleolin interacts with the rabbit hemorrhagic disease virus replicase RdRp, nonstructural proteins p16 and p23, playing a role in virus replication.  Virologica Sinica,  37:48-59. (IF: 6.9, Q2)

(4).  Zhu J, Wang X, Qi R, Tan Y, Li C, et al. (2021) Hemoglobin subunit beta interacts with the capsid, RdRp and VPg proteins, and antagonizes the replication of rabbit hemorrhagic disease virus.  Vet Microbiol , 259:109143. (IF: 3.293, Q1)

(5). Guo H#, Zhu J#, Miao Q, Qi R, Tang A, et al. (2020) RPS5 interacts with the Rabbit Hemorrhagic Disease Virus 3’ Extremities Region and plays a Role in Virus Replication,  Vet Microbiol . 249:108858. (Co-first Author, IF: 3.030, Q1)

(6). Wang X#, Zhu J#*, Zhang D, Liu G*. (2022) Ribosomal control in RNA virus-infected cells, Frontiers in Microbiology, 2022 (IF: 6.1, Q1)

(7). Qi, R#, Zhu J#, Miao, Q., Tang, A., Dong, D., et al. (2019) Bioinformatics analysis of capsid protein of different subtypes rabbit hemorrhagic disease virus.  BMC veterinary research  15, 423. (Co-first Author, IF: 1.835, Q1)

(8).  Qi R#, Meng C#, Zhu J#, et al. (2022) The outbreak of rabbit hemorrhagic virus type 2 in the interior of China may be related to imported semen. Virologica Sinica, 37(4). (IF: 6.9, Q1)