Lingyue YU
Professional Title: Associate Professor
Education: PhD
Supervisor Category: Master Supervisor
Research Fields: pathogenic mechanisms of porcine viral diseases and the development of novel vector vaccines
1. Introduction
My research focuses on the pathogenic mechanisms of porcine viral diseases and the development of novel vector vaccines. I have led projects funded by the National Natural Science Foundation and the Sub-Project of the National Key Research and Development Program during the 13th Five-Year Plan and 14th Five-Year Plan. My research mainly involves the immunology and pathogenesis of highly pathogenic porcine reproductive and respiratory syndrome (PRRS) and the development of new vaccines. I have established porcine reproductive and respiratory syndrome virus (PRRSV)-related detection and diagnostic methods. Based on the attenuated vaccine strain HuN4-F112 of highly pathogenic PRRSV, I have successfully constructed and obtained a series of novel genetically engineered vaccine candidates expressing exogenous genes using reverse genetic manipulation and gene recombination techniques. Some of these research achievements have been put into practical applications.
2.Contact Information
Office Telephone:021-34293773
Email:yulingxue@shvri.ac.cn
3. Representative Publications and Works
(1). Yuanhong Wang†, Junhan Song†, Xiaoying Deng, Junna Wang, Miao Zhang, Liu Yun, Pan Tang, Huili Liu, Yanjun Zhou, Guangzhi Tong, Guoxin Li*, Lingxue Yu*. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) of Porcine deltacoronavirus （PDCoV） Elicit Robust Protective Immune Responses in mice. Frontiers in Immunology.Front. Immunol.10.3389/fimmu.2024.1328266.
(2). Yuanhong Wang，Yun Liu , Junna Wang , Miao Zhang, Xiaoying Deng , Junhan Song , Jie Zhu, Lingxue Yu*, Guoxin Li*, Guangqing Liu*. An adenovirus-vectored vaccine based on the N protein of feline coronavirus elicit robust protective immune responses.Antiviral Research.2024.10.1016/j.antiviral.2024.105825
(3). Yuanhong Wang†, Junhan Song†, Xiaoying Deng, Junna Wang, Miao Zhang, Liu Yun, Pan Tang, Huili Liu, Yanjun Zhou, Guangzhi Tong, Guoxin Li*, Lingxue Yu*. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) of Porcine deltacoronavirus （PDCoV） Elicit Robust Protective Immune Responses in mice.
(4). Ben-jin Liu1, Ling-zhi Luo1,Zi-qi Shi, Hou-bin Ju, Guo-xin Li, Ling-xue Yu*, and Jin Cui*, Research Progress of Porcine Reproductive and Respiratory Syndrome Virus NSP2 Protein.Viruses.2023, 15(12), 2310.
(5). Jia-zeng Chen1, Ling-xue Yu1, Yan-jun Zhou, et al., Nonstructural protein 2 is critical to infection efficiency of highly pathogenic porcine reproductive and respiratory syndrome virus on PAMs and influence virulence in vivo.Viruses.2022 Nov 23;14(12):2613.doi: 10.3390/v14122613.
(6). Shuai-yong Wang1, Man-zhu Wang1, Ling-xue Yu1, et al.,Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus.Virologica Sinica. 2022;627-630.
(7). Ling-xue Yu, Yan-jun Zhou, Yi-feng Jiang,et al., Construction and in vitro evaluation of a recombinant live attenuated PRRSV expressing porcine GM-CSF. Virology Journal.2014,11:201.
(8). Ling-xue Yu1, Xin Wang1, Hai Yu, et al., The emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus with additional 120aa deletion in Nsp2region in Jiangxi, China. Transbound Emerg Dis. 2018; 1–9.
(9)."Early Prevention and Later Diagnosis and Treatment of Livestock and Poultry Diseases" published by Jiangsu Science and Technology Press, ISBN 978-7-5390-6880-0, 2019, 256 pages.
4.National Patent Granted
"Recombinant PRRSV Vaccine Strains Expressing GM-CSF and their Preparation Methods and Applications," granted national invention patent, patent number: ZL201410056557.7, announcement date: March 22, 2017.