一、个人简历

虞凌雪，博士，硕士生导师，中国农业科学院上海兽医研究所猪病毒性繁殖障碍创新团队副研究员，中国农业科学院生猪产业专家团骨干专家。主持国家自然科学基金、“十三五、十四五”国家重点研发计划子课题，公益性行业（农业）科研专项，以及勃林格殷格翰中国猪繁殖与呼吸综合征研究基金和上海市兽医生物技术重点实验室开放课题等。主要从事高致病性猪繁殖与呼吸综合征免疫与致病机理和新型疫苗研制等研究成功构建并获得了一系列PRRSV重组表达外源基因的新型基因工程疫苗候选株，相关研究成果已转化。在《Antiviral Research》、《Frontiers in Immunology》、《Transboundary and Emerging Diseases》和《Viruses》等国内外发表论文40余篇，其中SCI论文20余篇，授权专利1项。

二、联系方式

办公电话：021-34293773

邮 箱：yulingxue@shvri.ac.cn

三、代表论著

1. Yuanhong Wang†, Junhan Song†, Xiaoying Deng, Junna Wang, Miao Zhang, Liu Yun, Pan Tang, Huili Liu, Yanjun Zhou, Guangzhi Tong, Guoxin Li*, Lingxue Yu*. Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) of Porcine deltacoronavirus （PDCoV） Elicit Robust Protective Immune Responses in mice.Front. Immunol.10.3389/fimmu.2024.1328266.

2. Yuanhong Wang，Yun Liu , Junna Wang , Miao Zhang, Xiaoying Deng , Junhan Song , Jie Zhu, Lingxue Yu*, Guoxin Li*, Guangqing Liu*. An adenovirus-vectored vaccine based on the N protein of feline coronavirus elicit robust protective immune responses.Antiviral Research.2024.10.1016/j.antiviral.2024.105825

3. Ben-jin Liu¹, Ling-zhi Luo¹,Zi-qi Shi, Hou-bin Ju, Guo-xin Li, Ling-xue Yu*, and Jin Cui*, Research Progress of Porcine Reproductive and Respiratory Syndrome Virus NSP2 Protein.Viruses.2023, 15(12), 2310.

4. Jia-zeng Chen¹, Ling-xue Yu¹, Yan-jun Zhou, et al., Nonstructural protein 2 is critical to infection efficiency of highly pathogenic porcine reproductive and respiratory syndrome virus on PAMs and influence virulence in vivo.Viruses.2022 Nov 23;14(12):2613.doi: 10.3390/v14122613.

5. Shuai-yong Wang¹, Man-zhu Wang¹, Ling-xue Yu¹, et al.,Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus.Virologica Sinica. 2022;627-630.

6. Ling-xue Yu¹, Xin Wang¹, Hai Yu, et al., The emergence of a highly pathogenic porcine reproductive and respiratory syndrome virus with additional 120aa deletion in Nsp2region in Jiangxi, China. Transbound Emerg Dis. 2018; 1–9.

7. Ling-xue Yu, Yan-jun Zhou, Yi-feng Jiang,et al., Construction and in vitro evaluation of a recombinant live attenuated PRRSV expressing porcine GM-CSF. Virology Journal.2014,11:201.

8. 《畜禽疫病的前期预防与后期诊治》江苏科学技术出版社ISBN978-7-5390-6880-0,2019,256千字.（副主编）

四、专利标准

1．【表达GM-CSF重组PRRSV弱毒疫苗株及其制备方法和应用】，授权公告日：2017年3月22日，国家发明专利，专利号：ZL201410056557.7.