一、个人简历

田明星，男，博士，所聘研究员，硕士导师，中国农业科学院上海兽医研究所畜禽细菌性传染病风险预警与防控团队骨干专家。主要从事布鲁氏菌致病机制及其防控技术研究。作为项目负责人，主持科研项目11项，其中包括国家自然科学基金项目4项，国家重点研发项目子课题3项，上海市青年科技英才扬帆计划项目1项，中国博士后科学基金面上一等资助1项，中央级公益性科研院所基本科研业务费2项，参加其他国家或省部级课题10余项。发表论文70余篇，SCI收录40余篇，获得授权专利13项。

二、联系方式

办公电话：021-34293412

邮    箱：mxtian@shvri.ac.cn

三、代表性论文

1. Yang G, Li M, Li Y, Chen S, Qu J, Li J, Wang S, Bao Y, Qi J, Dou Y*, Tian M*. Disruption of purine de novo synthesis pathway impairs membrane homeostasis, intracellular survival, and virulence of Brucella melitensis. Front Microbiol. 2025, 16: 1721961.

2. Wang Y, Li M, Yang X, Yin Y, Liu J, Qu J, Bao Y, Qi J, Han X, Wang S*, Tian M*. The LysR-family transcriptional regulator VtlR coordinates carbon metabolism, oxidative and nitrosative stress resistance, and virulence in Brucella melitensis. Vet Res. 2025, 56(1):214. 

3. Liu J, Yin Y, Yang X, Li M, Qu J, Wang S, Bao Y, Qi J, Wu T*, Tian M*. Biological Characterization and DIVA Potential of Three Rough Brucella melitensis Vaccine Strains. Vaccines (Basel). 2025 Aug 13;13(8): 857.

4. Sun P, Yang X, Liu J, Bao Y, Qi J, Han X, Liu G, Wang S*, Tian M*. Development and Application of Colloidal Gold Test Strips for the Rapid Detection of Canine Brucellosis. Biosensors (Basel). 2024 Aug 10;14(8): 388.

5. Yin Y, Fang T, Lian Z, Zuo D, Hu H, Zhang G, Ding C, Tian M*, Yu S*. Erythronate utilization activates VdtR regulating its metabolism to promote Brucella proliferation, inducing abortion in mice. Microbiol Spectr 2023, 11(5): e0207423.

6. Abdelgawad HA, Lian Z, Yin Y, Fang T, Tian M*, Yu S*. Characterization of Brucella abortus Mutant A19mut2, a Potential DIVA Vaccine Candidate with a Modification on Lipopolysaccharide. Vaccines (Basel) 2023, 11(7).

7. Zuo D, Yin Y, Fang T, Jiang H, Ding J, Hu H, Wang S, Qi J, Tian M*, Yu S*. A homolog of low molecular weight protein tyrosine phosphatase isolated from Brucella melitensis displays an acidic dual specific phosphatase activity, nonessential for bacterial resistance to bactericidal factors and virulence. Comp Immunol Microbiol Infect Dis 2022, 90-91:101904.

8. Tian M#, Li Z#, Qu J, Fang T, Yin Y, Zuo D, Abdelgawad HA, Hu H, Wang S, Qi J, Wang G, Yu S. The novel LysR-family transcriptional regulator BvtR is involved in the resistance of Brucella abortus to nitrosative stress, detergents and virulence through the genetic regulation of diverse pathways. Vet Microbiol 2022, 267: 109393.

9. Cheng Z, Li Z, Yin Y, Lian Z, Abdelgawad HA, Hu H, Guan X, Zuo D, Cai Y, Ding C Wang S, Li T, Qi J, Tian M*, Yu S*. Characteristics of Brucella abortus vaccine strain A19 reveals its potential mechanism of attenuated virulence. Vet Microbiol 2021, 254: 109007.

10. Tian M#, Yin Y#, Lian Z, Li Z, Song M, Hu H, Guan X, Ding C, Wang S, Li T Qi J, Yu S. A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway. Vet Microbiol 2020, 244: 108648.

四、代表性专利

1. 一种gntR17基因缺失株M5ΔgntR17株及其构建方法与应用，2024年7月30日，中国，CN202411036081.0

2. 一株特异性分泌BP26抗体的单克隆细胞株2D3、单链抗体及制备方法，2024年7月20日，中国，CN202411037302.6

3. 一种布鲁菌减毒活疫苗菌株M5∆lysR21及其减毒方法与应用，2024年12月27日，中国，CN202411961527.0

4. pTM系列质粒载体、其构建方法以及在布鲁菌表达外源基因中的应用，2019年1月11日，中国，ZL201510690461.0