一、个人简历

田明星，博士，副研究员，硕士生导师。主要从事布鲁菌致病机制研究。主持国家自然布鲁菌致病机制研究科学基金2项，国家十四五重点研发计划子课题1项，国家十三五重点研发计划子课题1项，上海市青年科技英才扬帆计划1项，中国博士后科学基金资助一等资助，中央级公益性科研院所基本科研业务费专项2项。在《Infection and immunity》、《Veterinary microbiology》、《Transboundary and Emerging Diseases》等国内外期刊发表研究性论文70余篇，其中SCI论文40余篇。参编专著1部，获专利4项。

二、联系方式

办公电话：021-34293412

邮      箱：tianmx530@126.com; mxtian@shvri.ac.cn

三、代表论著

1. Tian M#, Li Z#, Qu J, Fang T, Yin Y, Zuo D, Abdelgawad HA, Hu H, Wang S, Qi J, Wang G, Yu S. The novel LysR-family transcriptional regulator BvtR is involved in the resistance of Brucella abortus to nitrosative stress, detergents and virulence through the genetic regulation of diverse pathways. Vet Microbiol 2022, 267: 109393.

2. Cheng Z, Li Z, Yin Y, Lian Z, Abdelgawad HA, Hu H, Guan X, Zuo D, Cai Y, Ding C, Wang S, Li T, Qi J, Tian M*, Yu S*. Characteristics of Brucella abortus vaccine strain A19 reveals its potential mechanism of attenuated virulence. Vet Microbiol 2021, 254: 109007.

3. Tian M#, Yin Y#, Lian Z, Li Z, Song M, Hu H, Guan X, Ding C, Wang S, Li T, Qi J, Yu S. A rough Brucella mutant induced macrophage death depends on secretion activity of T4SS, but not on cellular Txnip- and Caspase-2-mediated signaling pathway. Vet Microbiol 2020, 244: 108648.

4. Hu H, Tian M, Li P, Guan X, Lian Z, Yin Y, Shi W, Ding C, Yu S. Brucella Infection Regulates Thioredoxin-Interacting Protein Expression to Facilitate Intracellular Survival by Reducing the Production of Nitric Oxide and Reactive Oxygen Species. J Immunol 2020, 204: 632-643.

5. Tian M#, Song M#, Yin Y, Lian Z, Li Z, Hu H, Guan X, Cai Y, Ding C, Wang S, Li T, Qi, J, Yu S. Characterization of the main immunogenic proteins in Brucella infection for their application in diagnosis of brucellosis. Comp Immunol Microbiol Infect Dis 2020, 70: 101462.

6. Tian M#, Lian Z#, Bao Y, Bao S, Yin Y, Li P, Ding C, Wang S, Li T, Qi J, Wang X, Yu S. Identification of a novel, small, conserved hypothetical protein involved in Brucella abortus virulence by modifying the expression of multiple genes. Transbound Emerg Dis 2019, 66: 349-362.

7. Tian M, Qu J, Li P, Bao Y, Liu J, Ding C, Wang S, Li T, Qi J, Yu S. Identification of novel genes essential for Brucella abortus to establish infection by signature-tagged mutagenesis. Vet Microbiol 2019, 230: 130-137.

8. Li P, Tian M, Hu H, Yin Y, Guan X, Ding C, Wang S, Yu S. Lable-free based comparative proteomic analysis of secretory proteins of rough Brucella mutants. J Proteomics 2019, 195: 66-75.

9. Hu H, Tian M, Ding C, Yu S, The C/EBP Homologous Protein (CHOP) Transcription factor functions in endoplasmic reticulum stress-induced apoptosis and microbial infection. Front Immunol 2018: 9: 3083.

10. Tian M#, Bao Y#, Li P, Hu H, Ding C, Wang S, Li T, Qi J, Wang X, Yu S. The putative amino acid ABC transporter substrate-binding protein AapJ2 is necessary for Brucella virulence at the early stage of infection in a mouse model. Vet Res 2018, 49: 32.

四、专利标准

1．pTM系列质粒载体、其构建方法以及在布鲁菌表达外源基因中的应用，2015-10-22，中国，专利号：ZL201510690461.0。

2．禽致病性大肠杆菌灭活疫苗及其制备方法，2017年12月12日，中国，ZL201510215849.5。

3．一株鸭疫里默氏杆菌脂多糖突变株及其应用，2018年4月6日，中国，ZL201510030418.1。

4．检测鸭MAPK1基因的荧光定量RT-PCR方法，2016年4月20日，中国，