一、个人简历

刘珂，男，博士，副研究员，硕士生导师，猪呼吸道传染病团队。主要开展猪重要传染病的原创性研究，主要研究病毒RNA的转录翻译调控新机制，免疫逃逸和免疫抑制新机制，蚊媒病毒跨物种传播新机制以及新型核酸疫苗技术。主持“国家青年自然科学基金”一项，“上海市自然基金项目”两项，“国家重点研发子课题”一项，参与“农业部公益性行业科研专项-猪乙脑项目”,“973”项目,“科技部国际合作项目”,“上海市科委科技创新项目”等项目研究。第一作者或通讯作者发表SCI论文10余篇，其中发表在国际权威病毒学杂志《Journal of Virology》上3篇，并因在蚊媒传染病领域的特殊贡献，被国际学术组织“Faculty opinion”列为推荐文章。参与发表学术论文70多篇。申请获得国家发明专利5项，国际发明专利1项。

二、联系方式

办公电话：021-34293635

邮      箱：liuke@shvri.ac.cn

三、发表论文及著作

1. Liu, K., Xiao, C., Xi, S., Hameed, M., Wahaab, A., Shao, D., Li, Z., Li, B., Wei, J., Qiu, Y., et al. (2020). Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito. Journal of virology 94. （第一作者，Journal of virology 杂志Spotlight文章，国际学术组织Faculty opinions推荐文章）

2. Liu, K., Hou, F., Wahaab, A., Kang, L., Xie, F., Ma, X., Xia, Q., Xiao, C., Shao, D., Li, B., et al. (2021). Mosquito Defensin facilitates Japanese encephalitis virus infection by downregulating the C6/36 cell-surface antiviral protein HSC70B. Veterinary microbiology 253, 108971. 第一作者

3. Liu, K., Qian, Y., Jung, Y.S., Zhou, B., Cao, R., Shen, T., Shao, D., Wei, J., Ma, Z., Chen, P., et al. (2017). mosGCTL-7, a C-Type Lectin Protein, Mediates Japanese Encephalitis Virus Infection in Mosquitoes. Journal of virology 91. 第一作者

4. Liu, K., Xiao, C., Xi, S., Muddassar, H., Abdul, W., Shao, D., Li, Z., Li, B., Wei, J., Qiu, Y., et al. Mosquito defensins enhance Japanese encephalitis virus infection by facilitating virus adsorption and entry within mosquito. Journal of virology 第一作者

5. Liu, K., Feng, X., Ma, Z., Luo, C., Zhou, B., Cao, R., Huang, L., Miao, D., Pang, R., He, D., et al. (2012). Antiviral activity of phage display selected peptides against Porcine reproductive and respiratory syndrome virus in vitro. Virology 432, 73-80. 第一作者

6. Qi, P., Liu, K., Wei, J., Li, Y., Li, B., Shao, D., Wu, Z., Shi, Y., Tong, G., Qiu, Y., et al. (2017). Nonstructural Protein 4 of Porcine Reproductive and Respiratory Syndrome Virus Modulates Cell Surface Swine Leukocyte Antigen Class I Expression by Downregulating beta2-Microglobulin Transcription. Journal of virology 91. 第一作者

7. Huan, B., Liu, K., Li, Y., Wei, J., Shao, D., Shi, Y., Qiu, Y., Li, B., and Ma, Z. (2018). Porcine serum amyloid A3 is expressed in extrahepatic tissues and facilitates viral replication during porcine respiratory and reproductive syndrome virus infection. Developmental and comparative immunology 79, 51-58. 第一作者

8. Liu, K., Ma, G., Liu, X., Lu, Y., Xi, S., Ou, A., Wei, J., Li, B., Shao, D., Li, Y., et al. (2019). Porcine reproductive and respiratory syndrome virus counteracts type I interferon-induced early antiviral state by interfering IRF7 activity. Veterinary microbiology 229, 28-38. 第一作者

9. Liu, K., Xiao, C., Wang, F., Xiang, X., Ou, A., Wei, J., Li, B., Shao, D., Miao, D., Zhao, F., et al. (2018). Chemokine receptor antagonist block inflammation and therapy Japanese encephalitis virus infection in mouse model. Cytokine 110, 70-77. 第一作者

10. Xi, S., Liu, K., Xiao, C., Hameed, M., Ou, A., Shao, D., Li, B., Wei, J., Qiu, Y., Miao, D., et al. (2020). Establishment and characterization of the pig tonsil epithelial (PT) cell line as a new model for persist infection of Japanese Encephalitis Virus. Veterinary microbiology 242, 108587. 第一作者

四、专利标准

1. 一种重组抗病毒蛋白及其制备方法和应用: 中国, ZL201610340303.7[P]. 2021-04-23.

2. PIG TONSIL CELL LINE SUSCEPTIBLE TO JEV AND CONSTRUCTION METHOD THEREOF: 澳大利亚, 2020102162. 2020-09-07.

3.  一种复合猪α干扰素基因及其重组载体: 中国, 201010125057 [P]. 2011-10-12.

4. 一种能抑制乙型脑炎病毒复制与感染的shRNA及其应用: 中国, 2010105072987 [P]. 2012-10-14.

5.  一种能抑制乙型脑炎病毒复制与感染的shRNA及其应用: 中国, 2011103598136 [P]. 2012-10-14.

6. 一种重组鸡α干扰素基因及其重组载体: 中国, 2008101239974[P]. 2009-01-07.