一、个人简历

郑浩，博士，研究员，博士生导师，猪病毒性繁殖障碍疫病防控技术研究团队科研骨干。长期从事伪狂犬病毒和非洲猪瘟病毒研究，发表论文SCI论文20余篇，获得国家发明专利6项。主持完成国家重点研发项目子课题、国家自然科学基金青年基金项目、上海市自然基金项目和上海科技兴农重点项目各1项，中国农业科学院上海兽医研究所中央级公益性科研院所基本科研业务费专项资金项目2项。目前正主持国家重点研发项目子课题、上海市自然基金、上海市创新行动计划项目各1项，培养硕士研究生10名。

二、联系方式

办公电话：021-342937773

邮      箱：haozheng@shvri.ac.cn

三、代表论著

1. Tong-Yun Wang, Guo-Ju Sang, Qian Wang, Chao-Liang Leng, Zhi-Jun Tian, Jin-Mei Peng, Shu-Jie Wang, Ming-Xia Sun, Fan-Dan Meng, Hao Zheng*, Xue-Hui Cai*, Yan-Dong Tang*. Generation of Premature Termination Codon (PTC)-Harboring Pseudorabies Virus (PRV) via Genetic Code Expansion Technology. Viruses, 2022, 14(3):572.  

2. Xuelan Liu^#, Mingliang Zhang^#,Chao Ye, KeyueRuan, Aiyun Xu, Fei Gao, Guangzhi Tong, Hao Zheng*. Inhibition of the DNA-sensing pathway by pseudorabies virus UL24 protein via degradation of interferon regulatory factor 7. Veterinary Microbiology, 2021, 255: 109023

3. Lirong Zhang^#, KeyueRuan^#, Guoju Sang, Zhaoyang Xu, Wu Tong, Hai Yu, Tongling Shan, Fei Gao, Liwei Li, Ning Kong, Guangzhi Tong, Hao Zheng*. Tk-deleted pseudorabies virusretains high pathogenicity in rats. J Vet Res, 2021, 65: 401-405

4. Xuchen Zheng^#, Hao Zheng^#, Wu Tong, Guoxin Li, Tao Wang, Liwei Li, Fei Gao, Tongling Shan, Hai Yu, Yanjun Zhou, YafengQiu, Zhiyong Ma, Guangzhi Tong. Acidity/Alkalinity of Japanese Encephalitis Virus E Protein Residue 138 Alters Neurovirulence in Mice. Journal of Virology, 2018, 92(22): e00108-18

5. Tao Wang, Wu Tong, Chao Ye, Zhiqing Yu, Jing Chen, Fei Gao, Tongling Shan, Hai Yu, Li Liwei, Guoxin Li, Guangzhi Tong, Hao Zheng*. Construction of an infectious bacterial artificial chromosome clone of a pseudorabies virus variant: Reconstituted virus exhibited wild-type properties in vitro and in vivo. Journal of Virological Methods, 2018, 259:106–115.

6. Hao Zheng, Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Tao Wang, Fei Gao, Liwei Li, Tongling Shan, Guoxin Li, Guangzhi Tong*. A simple method for developing an infectious cDNA clone of Japanese encephalitis virus. Virus Genes, 2017, 53(1):4-14

7. Xuchen Zheng, Wu Tong, Fei Liu, Chao Liang, Fei Gao, Guoxin Li, Guangzhi Tong, Hao Zheng*. Genetic instability of Japanese encephalitis virus cDNA clones propagated in Escherichia coli. Virus Genes, 2016, 52: 195–203

8. Wu Tong, Guoxin Li, Chao Liang, Fei Liu, Qing Tian, Yanyun Cao, Lin Li, Xuchen Zheng, Hao Zheng*, Guangzhi Tong*. A live, attenuated pseudorabies virus strain JS-2012 deleted for gE/gI protects against both classical and emerging strains. Antiviral Research, 2016,130: 110-117

9.Yu Deng, Chun-Qing Sun, San-Jie Cao, Tao Lin , Shi-shan Yuan, Hong-Biao Zhang, Shao-Lun Zhai, Lv Huang, Hao Zheng*, Xin-Tian Wen, Guang-zhi Tong*. High prevalence of bovine viral diarrhea virus 1 in Chinese swine herds. Veterinary Microbiology, 2012, 159: 490–493

10. Hao Zheng, Changlong Liu, Jinshan Zhuang, Shishan Yuan. Baculovirus expression of cloned porcine arterivirus generates infectious particles in both insect and mammalian cells. Journal of Biotechnology, 2010, 150: 251–258

四、专利标准

1.【乙型脑炎病毒弱毒株重组感染性克隆质粒及其应用】，2013年，国家发明专利， ZL201310355065.3。

2.【表达猪瘟病毒E2蛋白的重组伪狂犬病毒毒株及其制备方法和应用】，2018年，国家发明专利，ZL201810627238.5。

3.【一种伪狂犬病毒JS-2012株感染性克隆质粒、构建方法与应用】，2017年，国家发明专利，ZL201710118726.9。

4.【伪狂犬病毒基因缺失弱毒株及其制备方法和应用】，2014年，国家发明专利，ZL201410002656.7。

5.【伪狂犬病毒基因工程gB重组弱毒疫苗株及应用】，2017年，国家发明专利，ZL201710212188.X。