一、个人简历

李丽薇，博士，副研究员，硕士生导师，猪病毒性繁殖障碍疫病防控技术研究团队科研助理。

长期从事猪繁殖与呼吸综合症病毒对宿主致病机制、诱导的宿主免疫反应、以及病毒蛋白与宿主之间的相互作用等研究工作。主持国家自然科学基金青年科学基金项目1项，上海市农委科技兴农项目1项，“十四五”重点研发项目子课题1项、上海市兽医生物技术重点实验室开放课题研究基金1项，中央级公益性科研院所基本科研业务费专项资金项目2项，在《Journal of Virology》、《Veterinary Microbiology》、《Virus Research》等国内外学术期刊发表论文20余篇，其中第一或共同第一作者SCI论文16篇，授权专利4项。

二、联系方式

办公电话：021-34293773

邮      箱：liliwei@shvri.ac.cn

三、代表论著

1. Liwei Li^#, Yuanzhe Bai^#, Yanjun Zhou, Yifeng Jiang, Wu Tong, Guoxin Li, Hao Zheng, Fei Gao*, Guangzhi Tong*. PSMB1 inhibits the replication of porcine reproductive and respiratory syndrome virus by recruiting NBR1 to degrade nonstructural protein 12 by autophagy. Journal of Virology, 2023, 97(1):e0166022.

2. Liwei Li^#, Sina Qiao^#, Jiachen Liu, Yanjun Zhou, Wu Tong, Shishan Dong, Changlong Liu, Yifeng Jiang, Ziqiang Guo, Haihong Zheng, Ran Zhao, Guangzhi Tong, Guoxin Li*, Fei Gao*. A highly efficient indirect ELISA and monoclonal antibody established against African swine fever virus pK205R. Frontiers in Immunology, 2023, 13:1103166.

3. Liwei Li^#, Sina Qiao^#, Guoxin Li, Wu Tong, Sishan Dong, Jiachen Liu, Ziqiang Guo, Haihong Zheng, Ran Zhao, Guangzhi Tong, Yanjun Zhou*, Fei Gao*. The Indirect ELISA and Monoclonal Antibody against African Swine Fever Virus p17 Revealed Efficient Detection and Application Prospects. Viruses, 2023, 15:50.

4. Liwei Li^#, Jinxia Chen^#, Zhengda Cao, Yunlei Cao, Ziqiang Guo, Wu Tong, Yanjun Zhou, Guoxin Li, Yifeng Jiang, Changlong Liu, Lingxue Yu, Sina Qiao, Jiachen Liu, Guangzhi Tong^*, Fei Gao^*. Recombinant bivalent live vectored vaccine against CSF and HP-PRRS revealed adequate heterogeneous protection against NADC30-like strain. Frontiers in Microbiology, 2022, 12:822749.

5. Xiaona Liu^#, Liwei Li^#, Fei Gao,Yifeng Jiang, Wanzhe Yuan, Guoxin Li, Lingxue Yu, Yanjun Zhou, Guangzhi Tong, Kuan Zhao*. cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity. Frontiers in Immunology, 2022, 13:887054.

6. Zhengda Cao^#, Jinxia Chen^#, Liwei Li^#, Jiachen Liu, Wu Tong, Yanjun Zhou, Guangzhi Tong, Guihua Wang*, Fei Gao*. A rescued NADC30-like virus by reverse genetic manipulation exhibits moderate virulence and a promising application perspective. Virus Research, 2022, 316:198801.

7. Yuanzhe Bai^#, Liwei Li^#, Tongling Shan, Xiaoyong Chen, Yujiao Zhang, Fei Gao, Yifeng Jiang, Yanjun Zhou, Guoxin Li, Lingxue Yu, Ning Kong, Zhiyong Ma, Guangzhi Tong*. Proteasomal degradation of nonstructural protein 12 by RNF114 suppresses porcine reproductive and respiratory syndrome virus replication. Veterinary Microbiology, 2020, 246, 108746.

8. Liwei Li^#, Kuan Zhao^#, Fei Gao, Yifeng Jiang, Tongling Shan, Wu Tong, Hao Zheng, Lingxue Yu, Guoxin Li, Zhiyong Ma, Guangzhi Tong*. Restriction of porcine reproductive and respiratory syndrome virus replication by galectin-1. Veterinary Microbiology, 2019, 235: 310-318.

9. Kuan Zhao^#, Liwei Li^#, Yifeng Jiang, Fei Gao, Yujiao Zhang, Wenying Zhao, Guoxin Li, Lingxue Yu, Yanjun Zhou, Guangzhi Tong*. Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination. Veterinary Microbiology, 2019, 233: 140-146.

10. Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Tongling Shan, Kuan Zhao, Yujiao Zhang, Lin Li, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.

四、 专利标准

1、【猪CD163蛋白单克隆抗体的制备方法、表位鉴定及应用】. 2020，中国国家知识产权局发明专利，ZL202010629062.4.

2、【表达海肾或萤火虫荧光素酶基因的PRRSV重组质粒的构建方法及应用】. 2015，中国国家知识产权局发明专利，ZL201510069182.2.

3、【表达猪瘟病毒E2蛋白重组PRRS病毒基因工程疫苗的构建方法和应用】. 2014，中国国家知识产权局发明专利，ZL201410801939.8.

4、【猪Delta冠状病毒N蛋白单克隆抗体及其抗原表位和应用】. 2022，中国国家知识产权局发明专利，ZL201711127879.6.