一、个人简历

李丽薇，博士，副研究员，硕士生导师，猪病毒性繁殖障碍疫病防控技术研究团队科研骨干。

长期从事猪繁殖与呼吸综合症病毒对宿主致病机制、诱导的宿主免疫反应以及病毒蛋白与宿主之间的相互作用等研究工作。主持国家自然基金、中国农科院青年创新专项、“十四五”重点研发项目子课题和上海市农委科技兴农项目等科研项目。在《mBio》、《Journal of Virology》、《International Journal of Biological Macromolecules》、《Veterinary Microbiology》等国内外学术期刊发表论文20余篇，授权国家发明专利10余件。

二、联系方式

办公电话：021-34293773

邮    箱：liliwei@shvri.ac.cn

三、教育经历

2006.09-2010.06 东北农业大学 动物医学（本硕）专业 学士

2010.09-2015.06 中国农业科学院上海兽医研究所 预防兽医学专业 博士

四、工作经历

2015.07-2018.07 中国农科院上海兽医研究所 博士后

2018.07-2018.12 中国农科院上海兽医研究所 助理研究员

2019.01至今 中国农科院上海兽医研究所 副研究员

五、 代表论著

1. Liwei Li, Jinxia Chen, Zhengda Cao, Ziqiang Guo, Jiachen Liu, Yanjun Zhou, Guangzhi Tong, Fei Gao. Engineering a live-attenuated porcine reproductive and respiratory syndrome virus vaccine to prevent RNA recombination by rewiring transcriptional regulatory sequence. mBio, 2025, 16(2): e02350-24.

2. Liwei Li, Yuanzhe Bai, Yanjun Zhou, Yifeng Jiang, Wu Tong, Guoxin Li, Haihong Zheng, Fei Gao, Guangzhi Tong. PSMB1 inhibits the replication of porcine reproductive and respiratory syndrome virus by recruiting NBR1 to degrade nonstructural protein 12 by autophagy. Journal of Virology, 2023, 97(1): e0166022.

3. Song Han, Hongyong Duan, Nan Yang, Shumao Wang, Fei Gao, Yifeng Jiang, Chaozhi Tang, Yanjun Zhou, Guangzhi Tong, Kuan Zhao, Liwei Li. Functional epitope mapping of porcine reproductive and respiratory syndrome virus nsp7α and nsp7β using monoclonal antibodies and development of a feasible ELISA. International Journal of Biological Macromolecules. 2025, 322(Pt 4):147104.

4. Hongyong Duan, Chaozhi Tang, Song Han, Nan Yang, Shumao Wang, Fei Gao, Guangzhi Tong, Kuan Zhao, Liwei Li. Single-B-cell cloning and recombinant antibodies generation to analyze the antigenicity of porcine reproductive and respiratory syndrome virus nonstructural protein 12. Veterinary Microbiology. 2025, 304:110506.

5. Liwei Li, Sina Qiao, Jiachen Liu, Yanjun Zhou, Wu Tong, Shishan Dong, Changlong Liu, Yifeng Jiang, Ziqiang Guo, Haihong Zheng, Ran Zhao, Guangzhi Tong, Guoxin Li, Fei Gao. A highly efficient indirect ELISA and monoclonal antibody established against African swine fever virus pK205R. Frontiers in Immunology, 2023, 13:1103166.

6. Liwei Li, Sina Qiao, Guoxin Li, Wu Tong, Sishan Dong, Jiachen Liu, Ziqiang Guo, Haihong Zheng, Ran Zhao, Guangzhi Tong, Yanjun Zhou, Fei Gao. The indirect ELISA and monoclonal antibody against African swine fever virus p17 revealed efficient detection and application prospects. Viruses, 2023, 15:50.

7. Liwei Li, Jinxia Chen, Zhengda Cao, Yunlei Cao, Ziqiang Guo, Wu Tong, Yanjun Zhou, Guoxin Li, Yifeng Jiang, Changlong Liu, Lingxue Yu, Sina Qiao, Jiachen Liu, Guangzhi Tong, Fei Gao. Recombinant bivalent live vectored vaccine against CSF and HP-PRRS revealed adequate heterogeneous protection against NADC30-like strain. Frontiers in Microbiology, 2022, 12:822749.

8. Liwei Li, Nannan Du, Jinxia Chen, Kuan Zhang, Wu Tong, Hao Zheng, Ran Zhao, Guangzhi Tong,Fei Gao. Establishment and application of a quantitative PCR method for E248R gene of African swine fever virus. Veterinary Sciences, 2022, 9(8):417.

9. Liwei Li, Kuan Zhao, Fei Gao, Yifeng Jiang, Tongling Shan, Wu Tong, Hao Zheng, Lingxue Yu, Guoxin Li, Zhiyong Ma, Guangzhi Tong. Restriction of porcine reproductive and respiratory syndrome virus replication by galectin-1. Veterinary Microbiology, 2019, 235: 310-318.

10. Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Tongling Shan, Kuan Zhao, Yujiao Zhang, Lin Li, Guangzhi Tong. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91.

六、 专利标准

1. 李丽薇、高飞、段宏勇、姜一峰、童武、周艳君、童光志、王树茂、韩松.【一种猪繁殖与呼吸综合征病毒解旋酶的抗原表位、抗体的制备及应用】. 2025. 专利号：ZL202410024495.5.

2. 李丽薇、段宏勇、韩松、杨楠、童武、王树茂.【一种PRRSV非结构蛋白12抗体的制备、表位鉴定及应用】. 2025. 专利号：ZL202510115642.4.

3. 李丽薇、高飞、乔思娜、周艳君、童光志、童武、李国新、刘佳晨、郭子强.【非洲猪瘟病毒pK205R蛋白的哺乳动物细胞表达、单克隆抗体制备、表位鉴定及应用】. 2025. 专利号：202211083911.6.

4. 李丽薇、高飞、姜一峰、周艳君、童光志、段宏勇、王树茂、童武.【猪繁殖与呼吸综合征病毒Nsp7单克隆抗体的制备、表位鉴定及应用】. 2024. 专利号：ZL202410083824.3.

5. 高飞、帅文娜、李丽薇、周艳君、姜一峰、童光志、郭子强、李佳乐、罗梦、曾一凡.【一种嵌合重组质粒pPRRSV-VP2-Y、其嵌合病毒及其应用】. 2025. 专利号：ZL202510187876.X.

6. 姜一峰、沈奇、李丽薇、虞凌雪、高飞、童光志、周艳君、刘长龙. 【一种调节MHC-II类反式激活因子CIITA基因的猪繁殖与呼吸综合征病毒活疫苗的构建及其应用】. 2024. 专利号：ZL202211136637.4.