一、个人简历

刘长龙，博士，博士生导师，猪病毒性繁殖障碍疫病防控技术研究团队科研骨干，上海市“浦江人才计划（A类）”，中国农业科学院“青年英才”入选者，Frontiers in Microbiology杂志编委。

长期从事动物病毒及其分子生物学方向的研究，主要以猪流行性腹泻病毒和非洲猪瘟病毒为主要研究对象，利用猪组织类器官，基因编辑，全基因组CRISPR/Cas9遗传筛选，转录组学机器学习以及各种组学技术并结合细胞生化、反向遗传等手段来深入研究病毒与宿主相互作用，发掘参与病毒复制的宿主因子及其作用机制，探索病毒的致病和免疫机制，并针对生产实际和产业需求，开展疫苗、抗病毒药物研发。共发表SCI文章20余篇，以第一作者和通讯作者在PNAS，Cancer Research，Viruses，Virus Research等发表多篇SCI论文。获得国家发明专利2项，美国专利1项。

二、联系方式

办公电话：021-34293773

邮      箱：liuchanglong@shvri.ac.cn

三、代表论著

1. Min Zhang; Lilei Lv; Hongming Cai; Yanhua Li; Fei Gao; Lingxue Yu; Yifeng Jiang; Wu Tong; Liwei Li; Guoxin Li; Guangzhi Tong*; Changlong Liu*. Long-Term Expansion of Porcine Intestinal Organoids Serves as an in vitro Model for Swine Enteric Coronavirus Infection. 2022, Frontiers in Microbiology, 13:865336. doi: 10.3389/fmicb.2022.865336.

2. Yujiao Zhang, Fei Gao, Liwei Li, Kuan Zhao, Shan Jiang, Yifeng Jiang, Lingxue Yu, Yanjun Zhou, Changlong Liu*, Guangzhi Tong*. Porcine Reproductive and Respiratory Syndrome Virus Antagonizes PCSK9's Antiviral Effect via Nsp11 Endoribonuclease Activity. Viruses, 2020. 12(6).

3. Changlong Liu, Carolyn E. Banister and Phillip J. Buckhaults. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Cancer Researh, 2019. 79(9): p. 2392-2403.

4. Changlong Liu, Carolyn E. Banister, Charles C. Weige, Diego Altomare, Joseph H. Richardson, Carlo M. Contreras and Phillip J. Buckhaults. PRDM1 silences stem cell-related genes and inhibits proliferation of human colon tumor organoids. Proc Natl Acad Sci U S A, 2018. 115(22): p. E5066-E5075.

5. Changlong Liu, Huawei Ding, Wenbo Zhu, Shaojie Jiang, Jianrong Xu, GangMing Zou. LIGHT regulates the adipogenic differentiation of mesenchymal stem cells. J Cell Biochem, 2013. 114(2): p. 346-53.

四、专利标准

Phillip J. Buckhaults；Changlong Liu；Carolyn E. Banister. 【Methods For Resensitizing P53-Null Cells To Cancer Chemotherapy】，2021，美国， US2020/0299777A1。