一、个人简历

于海，研究员，博士生导师，全国百篇优秀博士论文奖获得者、中国微生物学会兽医微生物学专业委员会委员、中国畜牧兽医学会动物传染病学分会青年学者专业组委员。长期从事猪病毒病分子流行病学、基因工程疫苗研制及分子致病机制研究，先后主持了国家重点研发计划课题、国家自然科学基金面上和青年项目、国家国际科技合作子课题、上海自然科学基金等项目，在《Emerging Infectious Diseases》、《Science》、《Journal of infection》、《Emerging Microbes & Infections》、《Journal of virology》、《Journal of clinical microbiology》等杂志上发表SCI论文100多篇，授权专利9项，获得临床批件疫苗产品1项，转基因安全评价疫苗产品3项。

二、联系方式

办公电话：021-342937773

邮    箱：haiyu@shvri.ac.cn

三、代表论著

1. Xiuhui Wang, Xiaomin Liu, Shuaiyong Wang, Qi Wang, Juan Wang, Manzhu Wang, Yun Yao, Yanjun Zhou, Tongling Shan, Wu Tong, Hao Zheng, Ning Kong, Yifeng Jiang, Changlong Liu, Guangzhi Tong, Hai Yu*. Identification of the Key Amino Acid Mutations in the PB2 and PA Proteins of Classical Swine H1N1 Influenza A Virus in Mammalian Adaptation. Emerging Microbes & Infections, 2026, 15(1):2602310.

2. Binjian Liu#, Hai Yu#, Zhanfei Yan#, Jinyue Guo, Shan Cai, Yingqin Hu, Yu Yang, Yulin Yan, Hao Liu, Kun Mei, Zhili Li, Limei Qin, Yong Li, Shujian Huang, Feng Wen*. Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin. Journal of virology, 2026, in press.

3. Shuai-Yong Wang#, Feng Wen#, Ling-Xue Yu, Juan Wang, Man-Zhu Wang, Jie-Cong Yan, Yan-Jun Zhou, Wu Tong, Tong-Ling Shan, Guo-Xin Li, Hao Zheng, Chang-Long Liu, Ning Kong, Guang-Zhi Tong, Hai Yu*. Potential Threats to Human Health from Eurasian Avian-Like Swine Influenza A(H1N1) Virus and Its Reassortants. Emerging Infectious Diseases, 2022, 28(7):1489-1493.

4. Shuaiyong Wang#, Manzhu Wang#, Lingxue Yu#, Juan Wanga, Jiecong Yan, Xinli Rong, Yanjun Zhou, Tongling Shan, Wu Tong, Guoxin Li, Hao Zheng, Guangzhi Tong, Hai Yu*. Genetic characterization and pathogenicity of a reassortant Eurasian avian-like H1N1 swine influenza virus containing an internal gene cassette from 2009 pandemic H1N1 virus. Virologica Sinica, 2022, 37(4):627-630.

5. Ying-Feng Sun, Jing Yang, Ye Liu, Wen-Zhong Li, Xiao-Xue Yu, Liu-An Li*, Hai Yu*. Emergence of Novel Recombinant Type 2 Porcine Reproductive and Respiratory Syndrome Viruses with high pathogenicity for piglets in China. Journal of infection, 2021, 83(5):607-635.

6. Jinyue Guo#, Hai Yu#, Congying Wang#, Sheng Yuan, Hailiang Sun, Jing Yang, Qing Cheng, Kaijian Luo, Yong Li, Zhili Li, Quan Liu, Shujian Huang, Feng Wen*. Re-emergence of Highly Pathogenic Avian Influenza A(H5N8) Virus In Domestic Goose, China. Journal of infection, 2021, 83(6):709-737. 

7. Jinyue Guo#, Hai Yu#, Jing Yang, Yong Li, Xuelian Zhang, Kun Mei, Shihong Chi, Sheng Yuan, Hao Liu, Saeed El-Ashram, Shujian Huang, Feng Wen*. Weighted gene co-expression network analysis revealed host transcriptional response to H1N1 influenza A virus infection. Journal of infection, 2021, 82(3):e4-e7.

8. Bao-Yang Ruan#, Yun Yao#, Shuai-Yong Wang#, Xiao-Qian Gong, Xiao-Min Liu, Qi Wang, Ling-Xue Yu, Shi-Qiang Zhu, Juan Wang, Tong-Ling Shan, Yan-Jun Zhou, Wu Tong, Hao Zheng, Guo-Xin Li, Fei Gao, Ning Kong, Hai Yu*, Guang-Zhi Tong, Protective efficacy of a bivalent inactivated reassortant H1N1 influenza virus vaccine against European avian-like and Classical swine influenza H1N1 viruses in mice, veterinary microbiology, 2020, 246:108724.

9. Xiu-Hui Wang#, Xiao-Qian Gong#, Feng Wen#, Bao-Yang Ruan, Ling-Xue Yu, Xiao-Min Liu, Qi Wang, Shuai-Yong Wang, Juan Wang, Yi-Feng, Zhang, Yan-Jun Zhou, Tong-Ling Shan, Wu Tong, Hao Zheng, Ning Kong, Hai Yu*, Guang-Zhi Tong, The Role of PA-X C-Terminal 20 Residues of Classical Swine Influenza Virus in Its Replication and Pathogenicity, veterinary microbiology, 2020, 251:108916.

10. Ying-Feng Sun, Lei Zhou, Ting Bian, Xiang-Xue Tian, Wei-Ke Ren, Chao Lu, Li Zhang, Xiu-Li Li, Mao-Sheng Cui, Han-Chun Yang*, Hai Yu*. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus, veterinary microbiology, 2018, 216:176-182.

四、专利标准

1.【重组欧洲禽源H1N1亚型猪流感疫苗株及其制备方法和应用】，2019年9月3日（授权），中国，ZL201510477308.X。

2.【猪繁殖与呼吸综合征病毒感染性克隆疫苗株及其应用】，2013年3月27日（授权），中国，ZL201010559005.X。

3.【表达GM-CSF重组PRRSV弱毒疫苗株及其制备方法和应用】，2017年3月22日（授权），中国，ZL201410056557.7。

4.【伪狂犬病毒基因缺失弱毒株及其制备方法和应用】，2018年9月7日（授权），中国，ZL201410002656.7。

5.【表达猪瘟病毒E2蛋白的重组伪狂犬病毒毒株及其制备方法和应用】，2022年2月8日（授权）,中国，CN201810627238.5。