一、个人简历

于海，博士，研究员，博士生导师，猪病毒性繁殖障碍疫病防控技术研究团队科研骨干，中国微生物学会兽医微生物学专业委员会委员、中国畜牧兽医学会动物传染病学分会青年学者专业组委员，2010年获教育部和国务院学位委员会颁发的“全国百篇优秀博士论文奖”，2015年度入选“上海市闵行区领军人才”，2016年度入选中国农业科学院青年英才计划"科研英才培育工程"。

长期从事猪病毒病分子流行病学、基因工程疫苗研制及分子致病机制等方向的研究，完成1项科技成果转化。主持国家自然科学基金面上项目、国家国际科技合作子课题、国家自然科学基金青年项目、上海自然科学基金等项目12项，培养（含联合培养）博士生2名、硕士生17名。以第一或通讯作者在《Emerging Infectious Diseases》、《journal of infection》、《journal of clinical microbiology》、《Transboundary and Emerging Diseases》、《veterinary microbiology》等杂志上发表SCI论文29篇，担任副主编编写《猪流感》专著1部，获专利6项。

二、联系方式

办公电话：021-342937773

邮      箱：haiyu@shvri.ac.cn

三、代表论著

1. Shuai-Yong Wang,1 Feng Wen,1 Ling-Xue Yu, Juan Wang, Man-Zhu Wang, Jie-Cong Yan, Yan-Jun Zhou, Wu Tong, Tong-Ling Shan, Guo-Xin Li, Hao Zheng, Chang-Long Liu, Ning Kong, Guang-Zhi Tong, Hai Yu*. Eurasian Avian-Like Swine Influenza A(H1N1) Virus and Its Reassortant Viruses are Potential Threats to Human Health. Emerging Infectious Diseases, 2022, in press.

2. Ying-Feng Sun*, Ye Liu, Jing Yang, Wen-Zhong Li, Xiao-Xue Yu, Liu-An Li, Shuai-Yong Wang, Hai Yu*. Recombination between NADC34-like and QYYZ-like strain of Porcine Reproductive and Respiratory Syndrome virus with high pathogenicity for piglets in China. Transboundary and Emerging Diseases, 2022. In press.

3. Ying-Feng Sun, Jing Yang, Ye Liu, Wen-Zhong Li, Xiao-Xue Yu, Liu-An Li*, Hai Yu*. Emergence of Novel Recombinant Type 2 Porcine Reproductive and Respiratory Syndrome Viruses with high pathogenicity for piglets in China. Journal of infection, 2021, 83(5):607-635.

4. Jinyue Guo^#, Hai Yu^#, Congying Wang^#, Sheng Yuan, Hailiang Sun, Jing Yang, Qing Cheng, Kaijian Luo, Yong Li, Zhili Li, Quan Liu, Shujian Huang, Feng Wen*. Re-emergence of Highly Pathogenic Avian Influenza A(H5N8) Virus In Domestic Goose, China. Journal of infection, 2021, 83(6):709-737.

5. Jinyue Guo^#, Hai Yu^#, Jing Yang, Yong Li, Xuelian Zhang, Kun Mei, Shihong Chi, Sheng Yuan, Hao Liu, Saeed El-Ashram, Shujian Huang, Feng Wen*. Weighted gene co-expression network analysis revealed host transcriptional response to H1N1 influenza A virus infection. Journal of infection, 2021, 82(3):e4-e7.

6. Bao-Yang Ruan^#, Yun Yao^#, Shuai-Yong Wang^#, Xiao-Qian Gong, Xiao-Min Liu, Qi Wang, Ling-Xue Yu, Shi-Qiang Zhu, Juan Wang, Tong-Ling Shan, Yan-Jun Zhou, Wu Tong, Hao Zheng, Guo-Xin Li, Fei Gao, Ning Kong, Hai Yu*, Guang-Zhi Tong, Protective efficacy of a bivalent inactivated reassortant H1N1 influenza virus vaccine against European avian-like and Classical swine influenza H1N1 viruses in mice, veterinary microbiology, 2020, 246:108724.

7. Xiu-Hui Wang^#, Xiao-Qian Gong^#, Feng Wen^#, Bao-Yang Ruan, Ling-Xue Yu, Xiao-Min Liu, Qi Wang, Shuai-Yong Wang, Juan Wang, Yi-Feng, Zhang, Yan-Jun Zhou, Tong-Ling Shan, Wu Tong, Hao Zheng, Ning Kong, Hai Yu*, Guang-Zhi Tong, The Role of PA-X C-Terminal 20 Residues of Classical Swine Influenza Virus in Its Replication and Pathogenicity, veterinary microbiology, 2020, 251:108916.

8. Ying-Feng Sun, Lei Zhou, Ting Bian, Xiang-Xue Tian, Wei-Ke Ren, Chao Lu, Li Zhang, Xiu-Li Li, Mao-Sheng Cui, Han-Chun Yang*, Hai Yu*. Efficacy evaluation of two commercial modified-live virus vaccines against a novel recombinant type 2 porcine reproductive and respiratory syndrome virus, veterinary microbiology, 2018, 216:176-182.

9. Bao-Yang Ruan^#, Feng Wen^#, Xiao-Qian Gong, Xiao-Min Liu, Qi Wang, Ling-Xue Yu, Shuai-Yong Wang, Peng Zhang, Hai-Ming Yang, Tong-Ling Shan, Hao Zheng, Yan-Jun Zhou, Wu Tong, Fei Gao, Guang-Zhi Tong*, Hai Yu*. Protective efficacy of a high-growth reassortant H1N1 influenza virus vaccine against the European Avian-like H1N1 swine influenza virus in mice and pigs, veterinary microbiology, 2018, 222:75-84.

10. Xiao-Qian Gong, Ying-Feng Sun, Bao-Yang Ruan,Xiao-Min Liu, Qi Wang, Hai-Ming Yang, Shuai-Yong Wang, Peng Zhang, Xiu-Hui Wang, Tong-Ling Shan, Wu Tong, Yan-Jun Zhou, Guo-Xin Li, Hao Zheng, Guang-Zhi Tong*, Hai Yu*. PA-X protein decreases replication and pathogenicity of swine influenza virus in cultured cells and mouse models, veterinary microbiology, 2017, 205:66-70.

四、专利标准

1.【重组欧洲禽源H1N1亚型猪流感疫苗株及其制备方法和应用】，2019年9月3日（授权），中国，ZL201510477308.X

2.【猪繁殖与呼吸综合征病毒感染性克隆疫苗株及其应用】，2013年3月27日（授权），中国，ZL201010559005.X

3.【表达GM-CSF重组PRRSV弱毒疫苗株及其制备方法和应用】，2017年3月22日（授权），中国，ZL201410056557.7

4.【伪狂犬病毒基因缺失弱毒株及其制备方法和应用】，2018年9月7日（授权），中国，ZL201410002656.7

5.【猪源盖塔病毒抗体、杂交瘤细胞株及其应用】，2020年7月8日（申请），中国，202010649175.0