一、个人简历

李泽君，研究员，博士，博士生导师，团队首席科学家。现任中国农业科学院上海兽医研究所副所长，国家病原微生物实验室生物安全专家委员会委员、中国畜牧兽医学会兽医公共卫生学分会理事长、上海市免疫学会畜牧兽医免疫专业委员会主任委员、兽药评审专家库专家，先后入选国家科技创新领军人才，全国农业科研杰出人才、科技部 “创新人才推进计划”中青年科技创新领军人才、上海市领军人才等，曾获国家自然科学奖二等奖一项、2015年获全国最美科技工作者和上海市五一劳动奖章。

长期从事禽病毒性传染病的基础与应用方向的研究，主持国家和省部级项目20余项，培养硕、博士生40余名。在PNAS、JVI等国内外期刊发表论文100余篇，其中SCI论文50余篇，累计被他人SCI论文引用达900余次，出版专著2部，获发明专利授权19项，获得新兽药注册证书2项和农业行业标准1项。

二、联系方式

办公电话：021-34293446

邮      箱：lizejun@shvri.ac.cn

三、代表论著

1. Pan, X., X. Shi, L. Zhao, D. Yan, F. Zhou, Q. Liu, C. Yuan, B. Xu, Z. Zhang, M. Yan, Q. Teng, and Z. Li, Amino acid mutations K54E and S154P in the neuraminidase attenuate H3N2 canine influenza virus in mice. J Gen Virol, 2026. 107(2). 

2.Yuan S, Fu R, Xu B, Wang W, Ding H, Pan X, Yuan C, Liu Q, Zhang Z, Teng Q, Shi X, Yan M, Jiao P, Yan D*, Li Z*. Identification of novel B-cell neutralizing epitopes in goose Astrovirus type 2. Vet Microbiol. 2026, 313: 110874.

3. Pan, X., Zhou, F., Shi, X., Liu, Q., Yan, D., Teng, Q., Yuan, C., Xu, B., Zhang, Z., Yan, M., & Li, Z. The Generation of a H9N2 Avian Influenza Virus with HA and C3d-P29 Protein Fusions and Vaccine Development Applications. Vaccines, 2025, 13(2), 99.

4. Shi X, Zhuang H, Shuo D, Li L, Pan S, Wu Z, Tang M, Yang W, Liu Q, Yuan C, Yan D, Pan X, Xu B, Zhang Z, Yan M, Teng Q, Li Z. Pathogenicity Evaluation and Virulence Gene Identification of an Attenuated Duck Enteritis Virus. Microorganisms, 2025, 13(11): 2537.

5. Li L, Yan D, Shuo D, Shi X, Yan M, Yuan C, Teng Q, Xu B, Pan X, Monique M van Oers, Liu Q, Gorben P Pijlman, Li Z. Transmission routes of cluster 3 Tembusu virus in ducks and chickens. J Gen Virol. 2025, 106(6): 002106.

6. Lu H, Tang M, Zhang Z, Wu M, Yuan C, Pan X, Liu Q, Teng Q, Xu B, Yan M, Yan D*, Wang F*, Li Z. The Isolation and Construction of an Infectious Clone for a Duck Adenovirus Type 3 Strain. Microorganisms. 2025, 13(6): 1319.

7. Tang M, Shi X, Xiong Y, Yuan C, Zhu Q, Huang M, Xu B, Liu Q, Pan X, Zhang Z, Teng Q, Yan M, Yan D*, Li Z*. Development of a Blocking ELISA for Detection of Serum Neutralizing Antibodies Against Duck Adenovirus Type 3. Microorganisms. 2025, 13(11): 2607.

8. Huang M, Shuo D, Xiong Y, Tang M, Wang Y, Pan X, Yuan C, Liu Q, Zhang Z, Teng Q, Xu B, Shi X, Yan M, Jiao P, Li Z*, Yan D*. Isolation and Characterization of a Duck Hepatitis A Virus Type 3 SH52 Strain in Ducklings. Microorganisms. 2025, 13(12): 2652.

9. Yan M, Ma T, Shi X, Chen Q, Li L, Xu B, Pan X, Teng Q, Yuan C, Yan D, Zhang Z, Liu Q, Li Z. Isolation and Characterization of H1 Subtype Swine Influenza Viruses Recently Circulating in China. Viruses. 2025 Jan 27;17(2):185.

10. Xue R, Bao D, Ma T, Niu S, Wu Z, Lv X, Zhang Y, Xu G, Yan D, Zhang Z, Pan X, Yan M, Teng Q, Yuan C, Li Z, Liu Q.  hnRNPH1 Inhibits Influenza Virus Replication by Binding Viral RNA. Microorganisms. 2024, 13(1): 24.

11. Pan X, Liu Q, Niu S, Huang D, Yan D, Teng Q, Li X, Beerens N, Forlenza M, de Jong MCM, Li Z. Efficacy of a recombinant turkey herpesvirus (H9) vaccine against H9N2 avian influenza virus in chickens with maternal-derived antibodies. Front Microbiol. 2023, 13: 1107975.

12. Pan X, Liu Q, de Jong MCM, Forlenza M, Niu S, Yan D, Teng Q, Li X, Beerens N, Li Z. Immunoadjuvant efficacy of CpG plasmids for H9N2 avian influenza inactivated vaccine in chickens with maternal antibodies. Vet Immunol Immunopathol. 2023, 259: 110590.

13. Xu B#, Liu X#, Yan D, Teng Q, Yuan C, Zhang Z, Liu Q, Li Z. Generation and characterization of chimeric Tembusu viruses containing pre-membrane and envelope genes of Japanese encephalitis virus. Frontiers in Microbiology. 2023, 14:1140141

14. Liu X#, Yan D#, Peng S, Zhang Y, Xu B, Li L, Shi X, Ma T, Li X, Teng Q, Yuan C, Liu Q, Li Z. 326K at E Protein Is Critical for Mammalian Adaption of TMUV. Viruses. 2023, 15(12): 2376. 

15. Pan, X., X. Su, P. Ding, J. Zhao, H. Cui, D. Yan, Q. Teng, X. Li, N. Beerens, H. Zhang, Q. Liu, M.C.M. de Jong, and Z. Li, Maternal-derived antibodies hinder the antibody response to H9N2 AIV inactivated vaccine in the field. Animal Diseases, 2022. 2(1).. doi: 10.1186/s44149-022-00040-0.

16. Yan W, Cui H, Engelsma M, Beerens N, van Oers MM, de Jong MCM, Li X, Liu Q, Yang J, Teng Q, Li Z. Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China. Microbiol Spectr. 2022, 10(1): e0082221.

17. Su X, Shuo D, Luo YQ, Pan X, Yan DW, Li XS, Lin WS, Huang DM, Yang JM, Yuan CX, Liu QF, Teng QY*, and Li ZJ*. An Emerging Duck Egg-Reducing Syndrome Caused by a Novel Picornavirus Containing Seven Putative 2A Peptides. Viruses, 2022, 14(5):932. 

18. Bao Danqi, Lu Chenyang,Ma Tianxina,XuGuanlong, MaoYaqing, Xin Lingxiang, NiuShiqi, Wu Zihua, Li Xuesong, Teng Qiaoyang, Li Zejun*, Liu Qinfang* Hydrophobic residues at intracellular domain of the M2 protein plays an important role in budding and membrane integrityof influenza virus. J Virol. 2022, 96(9): e0037322. 

19. Yan D, Wang B, Shi Y, Ni X, Wu X, Li X, Liu X, Wang H, Su X, Teng Q, Yang J, Liu Q*, Li Z*. A Single Mutation at Position 120 in the Envelope Protein Attenuates Tembusu Virus in Ducks. Viruses. 2022, 14(3): 447. 

20. Yan D, Li X, Wang Z, Liu X, Dong X, Fu R, Su X, Xu B, Teng Q, Yuan C, Zhang Z, Liu Q, Li Z. The emergence of a disease caused by a mosquito origin Cluster 3.2 Tembusu virus in chickens in China. Vet Microbiol. 2022, 272: 109500.

21. Bao D, Xue R, Zhang M, Lu C, Ma T, Ren C, Zhang T, Yang J, Teng Q, Li X, Li Z*, Liu Q*. N-Linked Glycosylation Plays an Important Role in Budding of Neuraminidase Protein and Virulence of Influenza Viruses. J Virol. 2021, 95(3): e02042-20.

22. Ma T, Nagy A, Xu G, Xin L, Bao D, Lu C, Niu S, Wu Z, Ren C, Zhang T, Yang J, Teng Q, Li X, Li Z*, Liu Q*. RNA-Seq Analysis of Influenza A Virus-Induced Transcriptional Changes in Mice Lung and Its Possible Implications for the Virus Pathogenicity in Mice. Viruses. 2021, 13(10): 2031.

23. Yang J*, Zhang P, Huang M, Qiao S, Liu Q, Chen H, Teng Q, Li X, Zhang Z, Yan D, Sun H, Li Z*. Key Amino Acids of M1-41 and M2-27 Determine Growth and Pathogenicity of Chimeric H17 Bat Influenza Virus in Cells and in Mice. J Virol. 2021, 95(19): e0101921.0

24. Lin W, Cui H, Teng Q, Li L, Shi Y, Li X, Yang J, Liu Q, Deng J,Li Z.Evolution and pathogenicity of H6 avian influenza viruses isolated from Southern China during 2011 to 2017 in mice and chickens.Sci Rep,2020,25;10(1),2045-2322.

25. Zhang M, Zhao C, Chen H, Teng Q, Jiang L, Feng D, Li X, Yuan S, Xu J*, Zhang X*, Li Z*. Internal Gene Cassette From a Human-Origin H7N9 Influenza Virus Promotes the Pathogenicity of H9N2 Avian Influenza Virus in Mice. Front Microbiol. 2020, 11: 1441.

26. Zhao K, Rong G, Teng Q, Li X, Lan H, Yu L, Yu S, Jin Z, Chen G, Li Z*.Dendrigraft poly-L-lysines delivery of DNA vaccine effectively enhances the immunogenic responses against H9N2 avian influenza virus infection in chickens. Nanomedicine. 2020, 27: 102209.

27. Yan D, Shi Y, Wang H, Li G, Li X, Wang B, Su X, Wang J, Teng Q, Yang J, Chen H, Liu Q, Ma W, Li Z*.A Single Mutation at Position 156 in the Envelope Protein of Tembusu Virus Is Responsible for Virus Tissue Tropism and Transmissibility in Ducks. J Virol. 2018, 92(17): e00427-18.

28. Teng Q, Xu D, Shen W, Liu Q, Rong G, Li X, Yan L, Yang J, Chen H, Yu H, Ma W, Li Z*. A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice. J Virol. 2016, 90(21): 9806-9825.

29. Li X, Shi Y, Liu Q, Wang Y, Li G, Teng Q, Zhang Y, Liu S, Li Z*. Airborne Transmission of a Novel Tembusu Virus in Ducks. J Clin Microbiol. 2015, 53(8):2734-6.

30. Li X, Li G, Teng Q, Wu X, Li Z*. Development of a blocking ELISA for detection of serum neutralizing antibodies against newly emerged duck Tembusu virus. PLoS One. 2012, 7(12): e53026.

31. 李泽君, 鸭坦布苏病毒病病原的分离鉴定及生物学特性研究. 中国家禽. 2011, 33(17): 34-35.

四、代表专利和标准

1. 稳定表达高致病性禽流感病毒HA蛋白的MDCK细胞系及其用途，2013年，中国发明专利，ZL201010106774.4

2. 鸭坦布苏病毒的单克隆抗体、杂交瘤细胞株及其应用， 2012年，中国发明专利，ZL201210030412.0

3. 一种鸭黄病毒及其疫苗、试剂盒，2014年，中国发明专利，ZL201010601050.7

4. 鸭布苏病毒弱毒株及其应用，2015年，中国发明专利，L201210279232.6

5. 鉴别鸭坦布苏病毒强毒株和弱毒疫苗株的试剂盒及其应用，2016年，中国发明专利，ZL201410142794.5

6.鸭坦布苏病毒E蛋白第三结构域重组蛋白及其应用，2017年，中国发明专利，ZL201410067680.9  

7. MONOCLONAL ANTIBODY AGAINST DUCK TEMBUSU VIRUS, HYBRIDOMA CELL LINE AND APPLICATION THEREOF，United States Patent  Us 9,500,652 B2

8. 鸭坦布苏病毒感染性克隆弱毒疫苗株及其制备方法和应用，2019年，中国发明专利，ZL201410283544.3

9. 抗H9亚型禽流感病毒的单克隆抗体、杂交瘤细胞株及应用，2019年，中国发明专利，ZL2015108235758

10.“鸭坦布苏病毒病诊断技术”农业行业标准（NY/T 3233-2018），2018年5月7日发布，2018年9月1日实施。

五、奖励成果

1. 国家自然科学二等奖，禽流感病毒进化、跨种感染及致病力分子机制研究，排名第五，证书号码：2013-Z-105-2-04-R05，2013年；

2. 国家新兽药注册证书，鸭坦布苏病毒病活疫苗(FX2010-180P株），证号：（2018）新兽药证字41号， 2018年；

3. 国家新兽药注册证书，鸭坦布苏病毒ELISA抗体检测试剂盒，证号：（2021）新兽药证字45号， 2021年。

4. 中国农业科学院科学技术成果奖（类别：杰出科技创行奖），鸭坦布苏病毒防控关键技术研发与应用，2024年。