一、个人简历

丁铲，男，汉族，获日本山口大学微生物学博士学位。现任中国农业科学院上海兽医研究所二级研究员，博士生导师，中国农科院家禽病毒病创新团队资深首席科学家，《中国动物传染病学报》主编，中国畜牧兽医学会副监事长、中国畜牧兽医学会禽病学分会副理事长、中国微生物学会兽医微生物学专业委员会副主任委员；上海交通大学、扬州大学、南京农业大学、广西大学、福建农林大学兼职教授；国务院特殊津贴获得者，有突出贡献专家，上海市领军人才。长期从事家禽病毒病的基础和应用研究，国家科技部“十三五”重点研发项目首席科学家、国家公益性行业（农业）专项首席科学家、主持国家自然基金重点项目（2项）等研究项目50余项，发表论文500多篇，被SCI收录200余篇，其中通讯作者100余篇，出版专著4部，先后获国家、部省级各种奖励10项。获得授权专利20余项。培养博士、硕士研究生 130多人。

二、联系方式

办公电话：021-34293441

邮      箱：shoveldeen@shvri.ac.cn

三、代表论著

[1] Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH,  Chan Ding*. Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells. Autophagy . 2021 Oct 31:1-19.

[2] Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun*, Chan Ding*.ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells.  PLoS Pathogens , 2020, 16(6):e1008514.

[3] Yuan Zhan, Shengqing Yu, Shen Yang, Xusheng Qiu, Chunchun Meng, Lei Tan, Cuiping Song, Ying Liao, Weiwei Liu, Yingjie Sun*, Chan Ding*. Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E.  PLoS Pathogens , 2020, 16(6):e1008610.

[4] Xianjin Kan, Yuncong Yin, Cuiping Song, Lei Tan, Xusheng Qiu, Ying Liao, Weiwei Liu, Songshu Meng, Yingjie Sun,* and Chan Ding*. Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells.  iScience , 2021, 24(8): 102837.

[5] Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding*, Yingjie Sun*.Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity.  mBio , 2021

[6] Peng T, Qiu X, Tan L, Yu S, Yang B, Dai J, Liu X, Sun Y, Song C, Liu W, Meng C, Liao Y, Yuan W, Ren T, Liu X, Ding C*.Ubiquitination on Lysine 247 of Newcastle Disease Virus Matrix Protein Enhances Viral Replication and Virulence by Driving Nuclear-Cytoplasmic Trafficking. J ournal of Virology . 2022 Jan 26;96(2):e0162921.

[7] Yingjie Sun†, Hang Zheng†, Shengqing Yu, Yunlei Ding, Wei Wu, Xuming Mao, Ying Liao, Chunchun Meng, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Fengyun Wu, and Chan Ding*.Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5. Journal of Virology , 2019;93(18): e00322-19

[8] Yanrong Li#; Weiyu Jiang; Qiaona Niu; Yingjie Sun; Chunchun Meng; Lei Tan; Cuiping Song; Xusheng Qiu; Ying Liao#*; Chan Ding*. eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus.  Cell death disease , 2019, 10(12): 891-905.

[9] Yingjie Sun, Luna Dong, Shengqing Yu, Xiaoxu Wang, Hang Zheng, Pin Zhang, Chunchun Meng, Yuan Zhan, Lei Tan, Cuiping Song, Xusheng Qiu, Guijun Wang, Ying Liao, and Chan Ding*. Newcastle disease virus induces stable formation of bona fide stress granules to facilitate viral replication through manipulating host protein translation.  FASEB Journal , 2017, 31 (4)

[10] Chunchun Meng; Xusheng Qiu; Shengqing Yu; Chuanfeng Li; Yingjie Sun; Zongyan Chen; Kaichun Liu; Xiangle Zhang; Lei Tan; Cuiping Song; Guangqing Liu; Chan Ding*. Evolution of Newcastle Disease Virus Quasispecies Diversity and Enhanced Virulence after Passage through Chicken Air Sacs.  Journal of Virology , 2015, 90(4): 2052-2063.

四、专利标准

[1] A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF, 授权时间：2022.04.19，美国专利号：US 11,305,007,B2

[2] 一种复合多表位表达盒、其组成的重组病毒及应用。授权时间：2022.06.10，中国专利号：ZL201810394542.

[3] 一种鹅源线粒体抗病毒信号蛋白及其应用，2021-08-03，中国，ZL201810367202.8

[4] 稳定表达仓鼠TIGAR基因的BHK细胞系及其构建方法和应用，授权时间：2021年8月，中国，专利授权号：ZL201910344592.1

[5] 鸡IBV S1蛋白的CD8+ T细胞抗原位表多肽. 授权时间：2016年2月3日，专利授权号：ZL 201310317878.3

[6] 一种具有抗新城疫病毒活性的鹅源基因RIG-I及应用. 授权时间：2016.2.3，专利授权号：ZL201210281895.1

[7] 检测犬猫钩端螺旋体的荧光定量PCR方法及其引物和检测试剂盒，授权时间：2012.10.10，专利授权号：ZL201010138082.8

[8] 一种I型鸭病毒性肝炎RT-LAMP检测试剂盒及其检测方法. 2011.09.01, 专利授权号ZL111026049.X

五、奖励成果

[1]  2016年度上海市科学技术奖二等奖，水禽主要疫病快速诊断与疫苗研究。丁铲,于圣青,邵华斌,汪铭书,张大丙,陈少莺,彭大新,黄瑜,许传田,胡奇林,秦爱建,刘光清,程安春,李泽君,仇旭升，2016年8月。

[2]  2016年度江苏省科学技术奖二等奖，水禽主要疫病快速诊断与防控技术的研究和应用。丁铲, 朱善元, 于圣青, 程安春, 陈少莺, 邵华斌, 汪铭书, 仇旭升, 王永娟, 王安平, 左伟勇，2016年。