一、个人简历

廖瑛，女，2007年获新加坡南洋理工大学博士学位。现任中国农业科学院上海兽医研究所研究员、博士生导师、家禽病毒病监测预警和防控团队首席科学家。担任中国畜牧兽医学会第十届禽病学会理事、上海农业系统知识分子联谊会理事、Frontiers in Veterinary Science, section Veterinary Infectious Diseases客座编委、Frontiers in Microbiology特邀客座主编、“病毒学报”第七届编委等，入选2015-2018年中国农业科学院青年英才、2020年闵行领军人才、上海领军人才后备人选等。

长期从事动物冠状病毒和新城疫病毒的研究，主要研究方向包括病毒分子病原学、病毒和宿主细胞相互作用、免疫逃逸和致病机制、流行传播规律、重组突变、组织嗜性的改变和跨物种传播机制、利用反向遗传克隆技术研发家禽病毒病载体疫苗等。主持国家级项目5项、地方项目5项，培养博士生6名、硕士生17名。在 Plos Pathogens, Journal of Virology, Cell Death & Disease, Journal of   I  mmunology,   Fron  tiers in Microbiology, Virology, Viruses, Veterinary Research, Journal of General Virology，Oncotarget, FEBS letter, BBRC,  病毒学报，中国动物传染病学报等国内外病毒学权威期刊发表论文70多篇，其中SCI论文50多篇，出版专著《家禽呼吸道疾病》一部（参编）。

二、联系方式

办公电话：02134680291

邮      箱：liaoying@shvri.ac.cn

三、代表论著

[1] Wenlian Weng^#, Qingyan Liu, Wenxiang Xue, Huan Wang, Shouguo Fang, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Ying Liao^*Characterization of the Protective Efficacy against QX Strain of a Recombinant Infectious Bronchitis Virus with H120 Backbone and QX Spike Gene. Front. Microbiol. 2022. June 17, 883642.

[2] Wenxiang Xue^#, Chan Ding, Kun Qian, Ying Liao^*. The interplay between coronavirus and type I IFN response. Frontiers in Microbiology. 2022. March 04. 805472.

[3] Bo Gao^#, Xiaoqian Gong^#, Shouguo Fang, Wenlian Weng, Huan Wang, Hongyan Chu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Maria Forlenza, Chan Ding, Ying Liao^*. Inhibition of Anti-viral Stress Granule Formation by coronavirus endoribonuclease nsp15 Ensures Efficient Virus Replication.   Plos Pathogens . 2021. Feb 26;17(2): e1008690.

[4] Huan Wang^#, Dingxiang Liu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding, Ying Liao^*. Upregulation of DUSP6 impairs infectious bronchitis virus replication by negatively regulating ERK pathway and promoting apoptosis.  Veterinary Research.  2021. Jan 11;52(1):7.

[5] Yanrong Li^#, Weiyu Jiang, Qiaona Niu, Yingjie Sun, Chunchun Meng, Lei Tan, Cuiping Song, Xusheng Qiu, Ying Liao^*#, Chan Ding^*.  eIF2α-CHOP-BCl2/JNK and IRE1α-XBP1/JNK Signaling Promote Apoptosis and Inflammation and Support the proliferation of Newcastle Disease Virus.  Cell death & Disease.  2019. Nov 26;10 (12):891.

[6] Han S^#, Mao L^#, Liao Y^#, Sun S, Zhang Z, Mo Y, Liu H, Zhi X, Lin S, Seo HS, Guo H^*. Sec62 Suppresses Foot-and-Mouth Disease Virus Proliferation by Promotion of IRE1α-RIG-I Antiviral Signaling.  Journal of Immunology.  2019 Jul 15;203 (2):429-440.

[7] Wang H^#, Yuan X, Sun Y, Mao X, Meng C, Tan L, Song C, Qiu X, Ding C, Liao Y^*. Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system.  Virology.  2019; 158:118-136.

[8] Fan XX^#, Han SC^#, YanD, GaoY, WeiYQ, LiuXT, Liao Y^*, Guo HC^*, Sun SQ^*. Foot-and–mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3C^pro.  Cell Death & Disease.  2017. Jan 19;8(1):e2561.

[9] Fung TS^#, Liao Y^*，Liu DX^*. Regulation of Stress Responses and Translational Control by Coronavirus. Viruses. 2016 Jul 4;8(7). pii: E184. doi: 10.3390/v8070184.

[10]  Liao Y^#*, Gu F^#, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C^*. 2016. Regulation of de novo Translation of Host Cells by Manipulation of PERK/PKR and GADD34-PP1 Activity during Newcastle Disease Virus Infection. J Gen Virol. 2016 Apr; 97 (4):867-79.

四、专利标准

[1] A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF.授权时间：2022.04.19，美国专利号：US 11,305,007,B2

[2] 一种复合多表位表达盒、其组成的重组病毒及应用。授权时间：2022.06.10，中国专利授权号：ZL201810394542.

[3] 一种鹅源线粒体抗病毒信号蛋白及其应用。授权时间：2021-08-03，中国专利授权号：ZL201810367202.8

[4] 稳定表达仓鼠TIGAR基因的BHK细胞系及其构建方法和应用。授权时间：2021.8, 中国专利授权号：ZL201910344592.1

[5] 一种表达Furin蛋白的细胞株及其在禽传染性支气管炎病毒培养中的应用。中国专利申请号：202011211170.6，2021年进入实审2021021000943510