一、个人简历

孔宁，博士，研究员，博士生导师，"农科英才"院级优秀青年英才，动物生物安全共性技术研究团队科研骨干。

长期从事猪流行性腹泻病毒致病性与宿主免疫机制方向的研究。主持国家自然科学基金、中国农业科学院青年创新专项任务、上海市自然科学基金、中国博士后科学基金、上海市兽医生物技术重点实验室开放课题研究基金和中央级公益性科研院所基本科研业务费专项资金等项目。在《Autophagy》、《Journal of Virology》、《Journal of Biological Chemistry》和《Microbiology Spectrum》等国内外发表论文80余篇，其中第一或通讯作者SCI论文27篇，获国家发明专利1项。获得中国畜牧兽医学会“猪肠道病”研究进步奖，中国农业科学院优秀博士后。

二、联系方式

办公电话：021-34293773

邮      箱：kongning@shvri.ac.cn

三、代表论著

（1） Ning Kong#, Tongling Shan#, Hua Wang, Yajuan Jiao, Yewen Zuo, Liwei Li, Wu Tong, Lingxue Yu, Yifeng Jiang, Yanjun Zhou, Guoxin Li, Fei Gao, Hai Yu, Hao Zheng & Guangzhi Tong. BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy. Autophagy 2020; 16:1737-52. IF=16.0

（2） Xiaoquan Wang #, Wu Tong #, Xinyu Yang #, Huanjie Zhai #, Wenzhen Qin, Changlong Liu, Hao Zheng, Hai Yu, Guangzhi Tong, Zhendong Zhang*, Ning Kong*, Tongling Shan*. RBM14 inhibits the replication of porcine epidemic diarrhea virus by recruiting p62 to degrade nucleocapsid protein through the activation of autophagy and interferon pathway. Journal of Virology. 2024 Mar 19;98(3):e0018224. IF=3.8

（3） Xueying Zhai#, Ning Kong#, Yu Zhang#, Yiyi Song#, Wenzhen Qin#, Xinyu Yang, Chenqian Ye, Manqing Ye, Wu Tong, Changlong Liu, Hao Zheng, Hai Yu, Wen Zhang, Xia Yang, Gaiping Zhang*, Guangzhi Tong*, Tongling Shan*. N protein of PEDV plays chess game with host proteins by selective autophagy. Autophagy. 2023;19(8):2338-2352. IF=13.3

（4） Xinyu Cao#, Yingyu Liu#, Wu Tong#, Wenzhen Qin, Xinyu Yang, Hai Yu, Hao Zheng, Wen Zhang, Guangzhi Tong, Ning Kong*, Tongling Shan*. POLM inhibits porcine epidemic diarrhea virus replication by degrading multiple viral structural proteins. Journal of Virology. 2025 Mar 18;99(3):e0227824. IF=3.8

（5） Yahe Wang #, Wu Tong #, Wenzhen Qin #, Xinyu Yang , Hai Yu, Hao Zheng, Wen Zhang, Guangzhi Tong, Chunmei Wang*, Ning Kong*, Tongling Shan*. Midnolin inhibits coronavirus proliferation by degrading viral proteins. Journal of Virology. 2025 Jun 17;99(6):e0036625. IF=3.8

（6） He Sun, Yuchang Liu, Xinyu Yang, Wenzhen Qin, Xiaoxiao Lu, Yizhen Wang, Wu Tong, Hai Yu, Hao Zheng, Guangzhi Tong, Tongling Shan*, Ning Kong*. Bovine coronavirus Nsp14 protein promotes viral replication by degrading TRAF3 to inhibit interferon production. Veterinary Microbiology. 2025 Nov;310:110708. IF= 2.7

（7） Xinyu Yang, Wenzhen Qin, Wu Tong, Hai Yu, Hao Zheng, Guangzhi Tong, Yu Zhang*, Ning Kong*, Tongling Shan*. PGAM5 suppresses porcine epidemic diarrhea virus replication via selective autophagy-mediated degradation of the viral nucleocapsid protein. Veterinary Microbiology. 2025 Dec:311:110765.

（8） Xinyu Yang#, Ning Kong#, Wenzhen Qin#, Xueying Zhai, Yiyi Song, Wu Tong, Liwei Li, Changlong Liu, Hao Zheng, Hai Yu, Wen Zhang*, Guangzhi Tong*, Tongling Shan*. PGAM5 degrades PDCoV N protein and activates type I interferon to antagonize viral replication. Journal of Virology. 2023;97(11):e0147023. IF=5.3

（9） Wenzhen Qin#, Ning Kong#, Yu Zhang#, Chunmei Wang#, Sujie Dong, Huanjie Zhai, Xueying Zhai, Xinyu Yang, Chenqian Ye, Manqing Ye, Wu Tong, Changlong Liu, Lingxue Yu, Hao Zheng, Hai Yu, Wen Zhang, Daoliang Lan, Guangzhi Tong*, Tongling Shan*. PTBP1 suppresses porcine epidemic diarrhea virus replication via inducing protein degradation and IFN production. Journal of Biological Chemistry. 2023;299(8):104987. IF=4.8

（10） Xingya Wang #, Ning Kong #, Chen Wang #, Wenzhen Qin, Xinyu Yang, Hai Yu, Wu Tong, Guangzhi Tong, Lin Li, Hao Zheng*, Tongling Shan*, Xuelan Liu*. Japanese encephalitis virus NS3 captures the protein translation element by interacting with HNRNPH1 to promote viral replication. International Journal of Biological Macromolecules. 2025 Feb;289:138826. IF= 8.4

四、专利标准

【抗猪流行性腹泻病毒N蛋白的单克隆抗体及其应用】，授权公告日：2019年03月29日，国家发明专利，专利号：ZL201410384478.9

五、奖励成果

1. 中国畜牧兽医学会，BI“猪肠道病”研究进步奖，2020年

2. 中国农业科学院优秀博士后，2019年