一、个人简历

叶文冲，广州中医药大学中药学博士，助理研究员，中国农业科学院上海兽医研究所博士后，入选闵行区春申金字塔人才（青年创新人才），长期从事候选小分子的成药性评价及微生物耐药应对研究，主持完成中央级公益性科研院所基本科研业务费专项资金项目1项，作为主要完成人参与国家自然科学基金、国家重点研究计划项目、上海市农业科技创新项目等多个项目。在《European Journal of Medicinal Chemistry》、《Archiv der Pharmazie》、《Bioorganic chemistry》等发表SCI论文15篇，参编专著1部。

二、 联系方式

办公电话：021-34293396

邮   箱：yewenchong5722@163.com

三、代表论著

1. Lv S.#, Ma R.M.#, Tang Q.#, Wang X.Y., Wang C.M., Zhang K.Y. Li H.K., Ye W.C.* and Zhou W.*, Discovery of 3,4-dihydropyrimidine derivatives as novel Anti-PEDV agents targeting viral internalization through a unique calcium homeostasis disruption mechanism, Eur J Med Chem 291 (2025) 117637. https://doi.org/10.1016/j.ejmech.2025.117637.

2. Yang X.P., Jiao Z.R., Fan C.C., Ye W.C., Sai Lv, Wang X.Y., Wang C.M., Zhang K.Y., Ke X.S.* and Zhou W.*, Macrocyclic Compounds: Unveiling Their Distinctive Antiviral Advantages in Medicinal Research, J Med Chem 68(20) (2025) 21035-21071. https://doi.org/10.1021/acs.jmedchem.5c02430.

3. Qiu F.M.#, Fan C.C#, Tang Q., Chandarajoti K., Wang X.Y., Zhang K.Y., Ye W.C., Wang C.M.* and Zhou W.*, Traditional Chinese Medicine: Dual Antibacterial Actions via Host Defense Balance and Bacterial Inhibition, Phytother Res  (2026). https://doi.org/10.1002/ptr.70235.

4. Ye W.C. #, Tang Q.#, Zhou T., Zhou C., Fan C., Wang X.Y., Wang C.M., Zhang K.Y., Liao G.C.* and Zhou W.*, Design, synthesis and biological evaluation of the positional isomers of the galactose conjugates able to target hepatocellular carcinoma cells via ASGPR-mediated cellular uptake and cytotoxicity, Eur J Med Chem 264 (2024) 115988. https://doi.org/10.1016/j.ejmech.2023.115988.

5. Chen W.M., Ye W.C., Long Y.H., Zhang Y., Zhou W., Wang W, Discovery of 2-phenylethyl chromones as potent and selective CYP1B1 inhibitors, J Enzyme Inhib Med Chem 41(1) (2026) 2598738. https://doi.org/10.1080/14756366.2025.2598738.

6. Zhou T.T., Hao J.K., Tang Q., Chandarajoti. K., Ye W.C., Fan C., Wang X.Y., Wang C.M., Zhang K.Y., Han X.G., Zhou W.*, and Ge Y.W.*, Antimicrobial activity and structure-activity relationships of molecules containing mono- or di- or oligosaccharides: An update, Bioorg Chem 148 (2024) 107406. https://doi.org/10.1016/j.bioorg.2024.107406.

7. Ge R.L., Zhou H.Y., Tang Q., Chandarajoti. K., Bai H. Wang X.Y., Zhang K.Y., Ye W.C., Han X.G., Wang C.M.* and Zhou W*. A novel alpha-mangostin derivative synergistic to antibiotics against MRSA with unique mechanisms, Microbiol Spectr 12(12) (2024) e0163124. https://doi.org/10.1128/spectrum.01631-24.

8. Zhou C.#, Ye W. C.#, Cao Y.J.#, Wang M.Z., Qi D.X., Liao G.C., Li H.K., Huang W.P., Chen W.M.* Wang X.Y.* and Zhou W.* A gulose moiety contributes to the belomycin (BLM) disaccharide selective targeting to lung cancer cells, Eur J Med Chem 226 (2021) 113866. https://doi.org/10.1016/j.ejmech.2021.113866.

9. He X.G.#, Li M.L.#, Ye W.C.# and Zhou W.*, Discovery of degradable niclosamide derivatives able to specially inhibit small cell lung cancer (SCLC), Bioorg Chem 107 (2021) 104574. https://doi.org/10.1016/j.bioorg.2020.104574.

10. Chen P.#, Wang S. B.#, Cao C. Y.#, Ye W. C., Wang M.Z., Zhou C., Chen W.M., Zhang X., Zhang K.Y.* and Zhou W.*, alpha-naphthoflavone-derived cytochrome P450 (CYP)1B1 degraders specific for sensitizing CYP1B1-mediated drug resistance to prostate cancer DU145: Structure activity relationship, Bioorg Chem 116 (2021) 105295. https://doi.org/10.1016/j.bioorg.2021.105295.

11. Li, M.L.#, Ye, W.C.#, Fu, K.S.#, Zhou, C.; Shi, Y.H., Huang, W.P., Chen, W.M., Hu, J.L., Jiang, Z.L.*, Zhou, W.*, Oligosaccharide-camptothecin conjugates as potential antineoplastic drugs: Design, synthesis and biological evaluation, Eur J Med Chem 202 (2020) 112509. https://doi.org/10.1016/j.ejmech.2020.112509.

12. Zhou, W.#, Ye, W.C.#, Degraders of membrane-associated proteins, in: Targeted Protein Degradation Technologies, Qin, J.J., Luan, X., Zhang, W.D. (Eds.), Academic Press, 2025, pp. 171-190. DOI: 10.1016/C2022-0-02752-5.