Recently, innovation team of Early Warning and Prevention of Swine Infectious Disease of SHVRI CAAS has published a review, entitled with Mechanistic role of TRIM26 in ViralInfection and Host Defense in Genes.
Background
TRIM proteins are a subfamily within the RING-type E3 ubiquitin ligase family, which plays a key role in various cellular processes, including innate immune responses. TRIM26, a member of the TRIM family has been reported to be important in various viral infections. To know mechanistic role of TRIM26 in viral infection would provide the meaningful information of understanding viral pathogenesis.
Review
In this review, they provide a detailed analysis of TRIM26’s structure and function, discussing known cellular processes and molecular mechanisms conferring the antiviral response, current constraints, and potential future applications, focusing primarily on TRIM26’s role in the antiviral response across various cellular contexts.
Funding
Mona Sharma, a PhD student from the Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences is the first author of the paper. Prof. Yafeng Qiu is the corresponding author. This study was supported by the National Key Research and Development Program of China (no. 2022YFD1800104), the National Natural Science Foundation of China (32273024), and the Natural Science Foundation of Shanghai (22ZR1475900).
