Zhiyong MA
Director/Deputy Secretary of the Party Committee
一、Introduction
Prof. Zhiyong Ma, Ph.D., doctoral supervisor, and the Chief Scientist of Risk Warning and Blocking Techniques for Swine Infectious Diseases Team. Prof. Ma is currently the Director and Deputy Secretary of the Party Committee of the Shanghai Institute of Veterinary Medicine, Chinese Academy of Agricultural Sciences, and the Chairman of the Shanghai Society of Animal Husbandry and Veterinary Medicine.
Engaged in long-term research on zoonotic diseases such as Japanese encephalitis and porcine respiratory infectious diseases, exploring the innate antiviral response mechanism and virus escape mechanism of hosts, searching for target molecules for antiviral drug design, and developing new diagnostic technologies and vaccines. Hosted over 20 national and provincial level projects. Published over 150 papers in domestic and foreign journals such as PLoS Pathgenes, Journal of Virology, and Journal of Biological Chemistry, including over 100 SCI papers and over 16 patents.
二、Contact
Tel:021-34293139
E-mail:zhiyongma@shvri.ac.cn
三、Representative Works
1. Ma X, Li C, Xia Q, Zhang Y, Yang Y, Wahaab A, Liu K, Li Z, Li B, Qiu Y, Wei J, Ma Z. Construction of a Recombinant Japanese Encephalitis Virus with a Hemagglutinin-Tagged NS2A: A Model for an Analysis of Biological Characteristics and Functions of NS2A during Viral Infection. Viruses. 2022 Mar 29;14(4):706. doi: 10.3390/v14040706. PMID: 35458436; PMCID: PMC9024733.
2. Hameed M, Wahaab A, Nawaz M, Khan S, Nazir J, Liu K, Wei J, Ma Z. Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift. Viruses. 2021 Feb 24;13(3):357. doi: 10.3390/v13030357. PMID: 33668224; PMCID: PMC7996159.
3. Wang X, Wu Z, Li Y, Yang Y, Xiao C, Liu X, Xiang X, Wei J, Shao D, Liu K, Deng X, Wu J, Qiu Y, Li B, Ma Z. p53 promotes ZDHHC1-mediated IFITM3 palmitoylation to inhibit Japanese encephalitis virus replication. PLoS Pathog. 2020 Oct 27;16(10):e1009035. doi: 10.1371/journal.ppat.1009035. Epub ahead of print. PMID: 33108395.
4. Li C, Di D, Huang H, Wang X, Xia Q, Ma X, Liu K, Li B, Shao D, Qiu Y, Li Z, Wei J, Ma Z. NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings. PLoS Pathog. 2020 Sep 3;16(9):e1008773. doi: 10.1371/journal.ppat.1008773. PMID: 32881988; PMCID: PMC7494076.
5. Liu K, Xiao C, Xi S, Hameed M, Wahaab A, Shao D, Li Z, Li B, Wei J, Qiu Y, Miao D, Zhu H, Ma Z. Mosquito Defensins Enhance Japanese Encephalitis Virus Infection by Facilitating Virus Adsorption and Entry within the Mosquito. J Virol. 2020 Oct 14;94(21):e01164-20. doi: 10.1128/JVI.01164-20.
6. Wei J, Hameed M, Wang X, Zhang J, Guo S, Anwar MN, Pang L, Liu K, Li B, Shao D, Qiu Y, Zhong D, Zhou B, Ma Z. Antiviral activity of phage display-selected peptides against Japanese encephalitis virus infection in vitro and in vivo. Antiviral Res. 2020 Feb;174:104673. doi: 10.1016/j.antiviral.2019.104673. Epub 2019 Dec 5. PMID: 31812636.
7. Anwar MN, Wang X, Hameed M, Wahaab A, Li C, Sharma M, Pang L, Malik MI, Liu K, Li B, Qiu Y, Wei J, Ma Z. Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain. Viruses. 2020 May 16;12(5):552. doi: 10.3390/v12050552. PMID: 32429445; PMCID: PMC7290960.
8. Hameed M, Khan S, Xu J, Zhang J, Wang X, Di, Chen Z, Anwar MN, Wahaab A, Ma X, Nawaz M, Liu K, Li B, Shao D, Qiu Y, Wei J, Ma Z. Detection of Japanese Encephalitis Virus in Mosquitoes from Xinjiang during Next Generation Sequencing Arboviral Surveillance. Transbound Emerg Dis. 2020 Jul 2. doi: 10.1111/tbed.13697. Epub ahead of print. PMID: 32614516.
9. Hameed M, Liu K, Anwar MN, Wahaab A, Safdar A, Di D, Boruah P, Xu J, Wang X, Li B, Zhu H, Nawaz M, Shao D, Qiu Y, Wei J, Ma Z. The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in Culex pipiens mosquitoes from China. PLoS Negl Trop Dis. 2019 Sep 26;13(9):e0007716. doi: 10.1371/journal.pntd.0007716. eCollection 2019 Sep.
10. Wei J, Wang X, Zhang J, Guo S, Pang L, Shi K, Liu K, Shao D, Qiu Y, Liu L, Widén F, Li B, Ma Z. Partial cross-protection between Japanese encephalitis virus genotype I and III in mice. PLoS Negl Trop Dis. 2019 Aug 2;13(8):e0007601. doi: 10.1371/journal.pntd.0007601. eCollection 2019 Aug.
四、Representative Patents and Standards
1. A Recombinant Vector and its Application in the Preparation or Screening of Anti Influenza Drugs, authorized on April 2, 2019, invention patent number: ZL2016101410142.9
2. A Recombinant Vector and its Application in the Preparation or Screening of Anti Influenza Drugs, authorized on April 2, 2019, invention patent number: ZL201610139667.9
3. SiRNA for Inhibiting Influenza Virus Related Genes and its Application, authorized on February 13, 2018, invention patent number: ZL201210019712.9
4. Host Related Genes that Inhibit Influenza Virus Replication and Their Screening Methods and Applications, authorized on April 6, 2018, invention patent number: ZL201210019736.4
5. SiRNA for Inhibiting Influenza Virus Related Genes and its Application, authorized on August 31, 2018, invention patent number: ZL201610139670.0
6. A Class of Anti Japanese Encephalitis Virus Infection Composition and its Application, authorized on October 23, 2018, invention patent number: ZL201510391532.7
7. Application of a Class of N - (2-thiazole) Benzamide Derivatives, authorized on September 11, 2013, invention patent number: ZL201010237252.8
8. Real Time Fluorescence Quantitative PCR Method and its Kit for One-Step Detection of Z/S Subtype of Ebola Virus, authorized on March 22, 2017, invention patent number: ZL201110312855.4
9. A Fluorescence Quantitative PCR Detection Method for Detecting Ebola Virus and its Primers and Reagent Kit, authorized on June 8, 2016, invention patent number: ZL201110312915.2
10. A Specialized Primer, Method, and Reagent Kit for Identifying Meishan Pigs or Their Meat Products, authorized on August 24, 2016, and invention patent number: ZL201510088708.1