Zejun LI

Deputy Director

一、Introduction

Prof. Zejun Li, Ph.D., doctoral supervisor. He is currently serve as the Deputy Director of Shanghai Veterinary Research Institute,CAAS. Prof. Li is a member of the National Biosafety Expert Committee for Pathogenic Microorganisms, Chairman of the Veterinary Public Health Branch of the Chinese Society of Animal Husbandry and Veterinary Medicine, Chairman of the Veterinary Immunology Professional Committee of the Shanghai Immunology Society, and an expert in the Animal Drug Evaluation Expert Database. Prof. Li has been selected as a national leading talent in scientific and technological innovation, a national outstanding agricultural research talent, a young and middle-aged leading talent in scientific and technological innovation under the "Innovative Talent Promotion Program" of the Ministry of Science and Technology, and a leading talent in Shanghai etc. He has received numerous awards, including the National Natural Science Award (second class) and the Shanghai May Day Labor Medal in 2015.

Prof. Li has been engaged in the research of avian viral infectious diseases for more than 20 years. He has hosted more than 20 national and provincial projects and supervised over 40 master's and doctoral students. He has published over 100 papers in domestic and international journals, including over 50 SCI papers, which have been cited more than 900 times. He has published two books and has been granted more than 10 invention patents. Prof. Li has also obtained two new veterinary drug registration certificates and one agricultural industry standard.

二、Contact

Tel: 021-34293446

E-mail: lizejun@shvri.ac.cn

三、Representative Publications

1. Yan D, Shi Y, Wang H, Li G, Li X, Wang B, Su X, Wang J, Teng Q, Yang J, Chen H, Liu Q, Ma W, Li Z*.A Single Mutation at Position 156 in the Envelope Protein of Tembusu Virus Is Responsible for Virus Tissue Tropism and Transmissibility in Ducks.J Virol. 2018 Aug 16;92(17):e00427-18.

2. Zhao K, Rong G, Teng Q, Li X, Lan H, Yu L, Yu S, Jin Z, Chen G, Li Z*.Dendrigraft poly-L-lysines delivery of DNA vaccine effectively enhances the immunogenic responses against H9N2 avian influenza virus infection in chickens.Nanomedicine. 2020 Jul;27:102209.

3. Bao D, Xue R, Zhang M, Lu C, Ma T, Ren C, Zhang T, Yang J, Teng Q, Li X, Li Z*, Liu Q*. N-Linked Glycosylation Plays an Important Role in Budding of Neuraminidase Protein and Virulence of Influenza Viruses. J Virol. 2021 Jan 13;95(3):e02042-20.

4. Yang J*, Zhang P, Huang M, Qiao S, Liu Q, Chen H, Teng Q, Li X, Zhang Z, Yan D, Sun H, Li Z*. Key Amino Acids of M1-41 and M2-27 Determine Growth and Pathogenicity of Chimeric H17 Bat Influenza Virus in Cells and in Mice. J Virol. 2021 Sep 9;95(19):e0101921.

5. Teng Q, Xu D, Shen W, Liu Q, Rong G, Li X, Yan L, Yang J, Chen H, Yu H, Ma W, Li Z*. A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice. J Virol. 2016 Oct 14;90(21):9806-9825.

6. Yan D, Wang B, Shi Y, Ni X, Wu X, Li X, Liu X, Wang H, Su X, Teng Q, Yang J, Liu Q*, Li Z*. A Single Mutation at Position 120 in the Envelope Protein Attenuates Tembusu Virus in Ducks.Viruses. 2022 Feb 22;14(3):447. doi: 10.3390/v14030447.

7. Ma T, Nagy A, Xu G, Xin L, Bao D, Lu C, Niu S, Wu Z, Ren C, Zhang T, Yang J, Teng Q, Li X, Li Z*, Liu Q*. RNA-Seq Analysis of Influenza A Virus-Induced Transcriptional Changes in Mice Lung and Its Possible Implications for the Virus Pathogenicity in Mice. Viruses. 2021 Oct 8;13(10):2031. doi: 10.3390/v13102031.

8. Zhang M, Zhao C, Chen H, Teng Q, Jiang L, Feng D, Li X, Yuan S, Xu J*, Zhang X*, Li Z*. Internal Gene Cassette From a Human-Origin H7N9 Influenza Virus Promotes the Pathogenicity of H9N2 Avian Influenza Virus in Mice. Front Microbiol. 2020 Jul 22;11:1441.Molecular and Antigenic Characterization of Avian H9N2 Viruses in Southern China.

9.Yan W, Cui H, Engelsma M, Beerens N, van Oers MM, de Jong MCM, Li X, Liu Q, Yang J, Teng Q, Li Z. Microbiol Spectr. 2022 Feb 23;10(1):e0082221. doi: 10.1128/spectrum.00822-21. Epub 2022 Jan 12.PMID: 35019707 Free PMC article.

10. Li X, Shi Y, Liu Q, Wang Y, Li G, Teng Q, Zhang Y, Liu S, Li Z*. Airborne Transmission of a Novel Tembusu Virus in Ducks. J Clin Microbiol. 2015, 53(8):2734-6.

四、Representative Patents and Standards

1. Stable Expression of Highly Pathogenic Avian Influenza Virus HA Protein in MDCK Cells and Its Applications, Chinese Patent No. ZL201010106774.4, 2013.

2. Monoclonal Antibodies against Duck Tembusu Virus, Hybridoma Cell Lines, and the Applications, Chinese Patent No. ZL201210030412.0, 2012.

3. A kind of Duck Flaviviruses and the Vaccine, Reagent Kit, Chinese Patent No. ZL201010601050.7, 2014.

4. Duck Tembusu Virus Attenuated Strain and Its Applications, Chinese Patent No. L201210279232.6, 2015.

5. Reagent Kit for Differentiating Virulent Strains of Duck Tembusu Virus and Attenuated Vaccine Strains, and Its Applications, Chinese Patent No. ZL201410142794.5, 2016.

6. Recombinant Protein of the Domain III of E Protein of Duck Tembusu Virus and Its Applications, Chinese Patent No. ZL201410067680.9, 2017.

7. Monoclonal Antibody Against Duck Tembusu Virus, Hybridoma Cell Line, and Application Thereof, United States Patent No. US 9,500,652 B2.

8. Infectious Clone of Attenuated Duck Tembusu Virus Vaccine and Its Production and Application, Chinese Patent No. ZL201410283544.3, 2019.

9. Monoclonal Antibodies Against H9 Subtype Avian Influenza Virus, Hybridoma Cell Lines, and Their Applications, Chinese Patent No. ZL2015108235758, 2019.

10. "Duck Tembusu Virus Disease Diagnostic Technology" Agricultural Industry Standard (NY/T 3233-2018), published on May 7, 2018, implemented on September 1, 2018.

五、Awarded Achievements

1. Second Prize of the National Natural Science Award, Research on the Evolution, Cross-Species Infection, and Pathogenicity Molecular Mechanism of Avian Influenza Virus, ranked fifth, Certificate No. 2013-Z-105-2-04-R05, 2013.

2. National New Veterinary Drug Registration Certificate, Duck Tembusu virus Disease Live Vaccine (FX2010-180P Strain), Certificate No. (2018) New Veterinary Drug Certificate No. 41, 2018.

3. National New Veterinary Drug Registration Certificate, Duck Tembusu Virus ELISA Antibody Detection Kit, Certificate No. (2021) New Veterinary Drug Certificate No. 45, 2021.