SHENGQING YU   Ph. D, Professor, Head of Division of Veterinary Public Health    E-mail: yus@shvri.ac.cn Tel: 021-34293461 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   1999-2002 Ph.D, Preventive Veterinary Medicine, Yamaguchi University, Yamaguchi, Japan 1985-1988 MS, Department of Veterinary Medicine, Jiangsu Agricultural College, Yangzhou, China 1978-1982 DVM, Department of Veterinary Medicine, Jiangsu Agricultural College, Yangzhou, China   Professional Experience   2008-Present, Professor, Head of Division of Veterinary Public Health, Shanghai Veterinary Research Institute, CAAS 2003-2008 Postdoctor, Bacterial Pathogenesis and Vaccine Research, National Institutes of Health (NIH), MD, USA 1988-2003, Professor, Head of Division of Veterinary Biological Technology, Jiangsu Institute of Poultry Sciences, Yangzhou, China 1982-1985, Veterinarian, Xuzhou Livestock Breeding Station, Xuzhou, China   Current Research Topics   Pathogenesis and vaccine research on waterfowl important pathogenic bacteria. Molecular mechanism for Brucella infection and cellular survival. Pathogenesis, immune mechanism, prevention and control technology research on Foodborne pathogenic bacteria.   Publications   1. Zou J, Wang X, Ding C, Tian M, Han X, Wang S, Yu S*. Characterization and cross-protection evaluation of M949_1603 gene deletion Riemerella anatipestifer mutant RA-M1. Appl Microbiol Biotechnol. 2015 Aug 13. [Epub ahead of print]   2. Han X, Liu L, Fan G, Zhang Y, Xu D, Zuo J, Wang S, Wang X, Tian M, Ding C, Yu S*. Riemerella anatipestifer lacks luxS, but can uptake exogenous autoinducer-2 to regulate biofilm formation. Res Microbiol. 2015 Jul-Aug;166(6):486-93. doi: 10.1016/j.resmic.2015.06.004. Epub 2015 Jun 24.   3. Wang X, Ding C, Wang S, Han X, Yu S*. Whole-Genome Sequence Analysis and Genome-Wide Virulence Gene Identification of Riemerella anatipestifer Strain Yb2. Appl Environ Microbiol. 2015 Aug 1;81(15):5093-102. doi: 10.1128/AEM.00828-15. Epub 2015 May 22.   4. Han X, Bai H, Tu J, Yang L, Xu D, Wang S, Qi K, Fan G, Zhang Y, Zuo J, Tian M, Ding C, Yu S*. Deletion of luxS further attenuates the virulence of the avian pathogenic Escherichia coli aroA mutant. Microb Pathog. 2015 Aug 10;88:39-47. doi: 10.1016/j.micpath.2015.08.003. [Epub ahead of print]   5. Hou W, Wang S, Wang X, Han X, Fan H, Cao S, Yue J, Wang Q, Jiang W, Ding C, Yu S*. Development of colloidal gold immunochromatographic strips for detection of Riemerella anatipestifer. PLoS One. 2015 Mar 30;10(3):e0122952. doi: 10.1371/journal.pone.0122952. eCollection 2015.   6. Zou J, Wang X, Tian M, Cao S, Hou W, Wang S, Han X, Ding C, Yu S*. The M949_1556 gene plays a role on the bacterial antigenicity and pathogenicity of Riemerella anatipestifer. Vet Microbiol. 2015 May 15;177(1-2):193-200. doi: 10.1016/j.vetmic.2015.03.003. Epub 2015 Mar 14.   7. Wang X, Ding C, Han X, Wang S, Yue J, Hou W, Cao S, Zou J, Yu S*. Complete Genome Sequence of Riemerella anatipestifer Serotype 1 Strain CH3. Genome Announc. 2015 Feb 19;3(1). pii: e01594-14. doi: 10.1128/genomeA.01594-14.   8. Wang S, Dai J, Meng Q, Han X, Han Y, Zhao Y, Yang D, Ding C, Yu S*. DotU expression is highly induced during in vivo infection and responsible for virulence and Hcp1 secretion in avian pathogenic Escherichia coli. Front Microbiol. 2014 Nov 7;5:588. doi: 10.3389/fmicb.2014.00588. eCollection 2014.   9. Wang X, Ding C, Wang S, Han X, Hou W, Yue J, Zou J, Yu S*. The AS87_04050 gene is involved in bacterial lipopolysaccharide biosynthesis and pathogenicity of Riemerella anatipestifer. PLoS One. 2014 Oct 10;9(10):e109962. doi: 10.1371/journal.pone.0109962. eCollection 2014.   10. Cao S, Han X, Ding C, Wang S, Tian M, Wang X, Hou W, Yue J, Wang G, Yu S*. Molecular cloning of the duck mitogen-activated protein kinase 1 (MAPK1) gene and the development of a quantitative real-time PCR assay to detect its expression. Poult Sci. 2014 Sep;93(9):2158-67. doi: 10.3382/ps.2013-03796. Epub 2014 Jun 28.   11. Han Y, Han X, Wang S, Meng Q, Zhang Y, Ding C, Yu S*. The waaL gene is involved in lipopolysaccharide synthesis and plays a role on the bacterial pathogenesis of avian pathogenic Escherichia coli. Vet Microbiol. 2014 Aug 27;172(3-4):486-91. doi: 10.1016/j.vetmic.2014.05.029. Epub 2014 Jun 6.   12. Han X, Tong Y, Tian M, Zhang Y, Sun X, Wang S, Qiu X, Ding C, Yu S*. Enzymatic activity analysis and catalytic essential residues identification of Brucella abortus malate dehydrogenase. Scientific World Journal. 2014;2014:973751. doi: 10.1155/2014/973751. Epub 2014 May 7.   13. Wang S, Meng Q, Dai J, Han X, Han Y, Ding C, Liu H, Yu S*. Development of an allele-specific PCR assay for simultaneous sero-typing of avian pathogenic Escherichia coli predominant O1, O2, O18 and O78 strains. PLoS One. 2014 May 7;9(5):e96904. doi: 10.1371/journal.pone.0096904. eCollection 2014.   14. Tian M, Qu J, Han X, Ding C, Wang S, Peng D, Yu S*. Mechanism of Asp24 upregulation in Brucella abortus rough mutant with a disrupted O-antigen export system and effect of Asp24 in bacterial intracellular survival. Infect Immun. 2014 Jul;82(7):2840-50. doi: 10.1128/IAI.01765-14. Epub 2014 Apr 21.   15. Han X, Tong Y, Tian M, Sun X, Wang S, Ding C, Yu S*. Characterization of the immunogenicity and pathogenicity of malate dehydrogenase in Brucella abortus. World J Microbiol Biotechnol. 2014 Jul;30(7):2063-70. doi: 10.1007/s11274-014-1631-2. Epub 2014 Mar 8.   16. Han X, Sun X, Shan X, Zhang M, Song J, Tian M, Fan G, Wang S, Tong Y, Ding C, Yu S*. In vivo-induced argininosuccinate lyase plays a role in the replication of Brucella abortus in RAW264.7 cells. Microbiology. 2014 Mar;160(Pt 3):567-75. doi: 10.1099/mic.0.072926-0. Epub 2014 Jan 13.   17. Tian M, Qu J, Han X, Zhang M, Ding C, Ding J, Chen G, Yu S*. Microarray-based identification of differentially expressed genes in intracellular Brucella abortus within RAW264.7 cells. PLoS One. 2013 Aug 7;8(8):e67014. doi: 10.1371/journal.pone.0067014. eCollection 2013.   18. Zhang M, Han X, Liu H, Tian M, Ding C, Song J, Sun X, Liu Z, Yu S*. Inactivation of the ABC transporter ATPase gene in Brucella abortus strain 2308 attenuated the virulence of the bacteria. Vet Microbiol. 2013 Jun 28;164(3-4):322-9. doi: 10.1016/j.vetmic.2013.02.017. Epub 2013 Feb 28.   19. Liu H, Wang X, Ding C, Han X, Cheng A, Wang S, Yu S*. Development and evaluation of a trivalent Riemerella anatipestifer-inactivated vaccine. Clin Vaccine Immunol. 2013 May;20(5):691-7. doi: 10.1128/CVI.00768-12. Epub 2013 Mar 6.   20. Han X, Bai H, Liu L, Dong H, Liu R, Song J, Ding C, Qi K, Liu H, Yu S*. The luxS gene functions in the pathogenesis of avian pathogenic Escherichia coli. Microb Pathog. 2013 Feb;55:21-7. doi: 10.1016/j.micpath.2012.09.008. Epub 2012 Oct 6.   21. Hu Q, Zhu Y, Tu J, Yin Y, Wang X, Han X, Ding C, Zhang B, Yu S*. Identification of the genes involved in Riemerella anatipestifer biofilm formation by random transposon mutagenesis. PLoS One. 2012;7(6):e39805. doi: 10.1371/journal.pone.0039805. Epub 2012 Jun 29.   22. Hu Q, Ding C, Tu J, Wang X, Han X, Duan Y, Yu S*. Immunoproteomics analysis of whole cell bacterial proteins of Riemerella anatipestifer. Vet Microbiol. 2012 Jun 15;157(3-4):428-38. doi: 10.1016/j.vetmic.2012.01.009. Epub 2012 Jan 17.   23. Han X, Hu Q, Ding S, Chen W, Ding C, He L, Wang X, Ding J, Yu S*. Identification and immunological characteristics of chaperonin GroEL in Riemerella anatipestifer. Appl Microbiol Biotechnol. 2012 Feb;93(3):1197-205. doi: 10.1007/s00253-011-3635-2. Epub 2011 Oct 27.   24. Han X, Ding C, He L, Hu Q, Yu S*. Development of loop-mediated isothermal amplification (LAMP) targeting the GroEL gene for rapid detection of Riemerella anatipestifer. Avian Dis. 2011 Sep;55(3):379-83.   25. Hu Q, Tu J, Han X, Zhu Y, Ding C, Yu S*. Development of multiplex PCR assay for rapid detection of Riemerella anatipestifer, Escherichia coli, and Salmonella enterica simultaneously from ducks. J Microbiol Methods. 2011 Oct;87(1):64-9. doi: 10.1016/j.mimet.2011.07.007. Epub 2011 Jul 21.   26. Han X, Ding C, Chen H, Hu Q, Yu S*. Enzymatic and biological characteristics of enolase in Brucella abortus A19. Mol Biol Rep. 2012 Mar;39(3):2705-11. doi: 10.1007/s11033-011-1025-6. Epub 2011 Jun 15.   27. Hu Q, Han X, Zhou X, Ding C, Zhu Y, Yu S*. OmpA is a virulence factor of Riemerella anatipestifer. Vet Microbiol. 2011 Jun 2;150(3-4):278-83. doi: 10.1016/j.vetmic.2011.01.022. Epub 2011 Feb 1.   28. Hu Q, Han X, Zhou X, Ding S, Ding C, Yu S*. Characterization of biofilm formation by Riemerella anatipestifer. Vet Microbiol. 2010 Aug 26;144(3-4):429-36. doi: 10.1016/j.vetmic.2010.02.023. Epub 2010 Feb 21.   29. Yu S, Xie H, Datta A, Naidu N, Gu XX. Galactose residues on the lipooligosaccharide of Moraxella catarrhalis 26404 form the epitope recognized by the bactericidal antiserum from conjugate vaccination. Infect Immun. 2008 Sep;76(9):4251-8. doi: 10.1128/IAI.01570-07. Epub 2008 Jun 16.   30. Yu S, Gu XX. Biological and immunological characteristics of lipooligosaccharide-based conjugate vaccines for serotype C Moraxella catarrhalis. Infect Immun. 2007 Jun;75(6):2974-80. Epub 2007 Mar 19.   31. Yu S, Gu XX. Synthesis and characterization of lipooligosaccharide-based conjugate vaccines for serotype B Moraxella catarrhalis. Infect Immun. 2005 May;73(5):2790-6   32. Yu S, Shinya K, Otsuki K, Ito H, Ito T. Isolation of myxoviruses from migratory waterfowls in San-in district, western Japan in winters of 1997-2000. J Vet Med Sci. 2002 Nov;64(11):1049-52.   33. Yu S, Kishida N, Ito H, Kida H, Otsuki K, Kawaoka Y, Ito T. Generation of velogenic Newcastle disease viruses from a nonpathogenic waterfowl isolate by passaging in chickens. Virology. 2002 Sep 30;301(2):206-11.