Yang Hong   Ph.D, Associate professor   E-mail: hongyang_7@126.com Tel: 021-34293618 (O) Address: No. 518, Ziyue Road, Minhang District, Shanghai, 200241, China;   Education   2006-2011 Ph.D, Veterinary Parasitology, Nanjing Agriculture University                        (NAU), Nanjing, China 2002-2006 B.S. in Veterinary Medicine, Nanjing Agriculture University                        (NAU), Nanjing, China.   Professional Experience   2013-Present, Associate Professor, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science (CAAS), Key Laboratory of Animal Parasitology, Ministry of Agriculture of China 2011-2013, Post-doctoral, Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science (CAAS), Key Laboratory of Animal Parasitology, Ministry of Agriculture of China    Current Research Topics   The relationship between schistosomes and hosts Proteomics, immunoproteomic, post-translational modifications (PTMs) analysis of schistosomes Screening diagnostic markers, vaccine candidates and drug targets for schistosomiasis     Publications   1.Yang Hong, Min Zhang, Jianmei Yang, Xiaodan Cao, Qian Han, Yanhui Han, Chunhui Qiu, Chuangang Zhu, Ke Lu, Hao Li, Zhiqiang Fu, Jiaojiao Lin. Immunoproteomic analysis of Schistosoma japonicum schistosomulum proteins recognized by immunoglobulin G in the sera of susceptible and non-susceptible hosts. J Proteomics, 2015, 124: 25-38. 2.Min Zhang, Zhiqiang Fu, Changjian Li, Yanhui Han, Xiaodan Cao, Hongxiao Han, Yantao Liu, Ke Lu, Yang Hong*, Jiaojiao Lin*. Screening Diagnostic Candidates for Schistosomiasis from Tegument Proteins of Adult Schistosoma japonicum Using an Immunoproteomic Approach. PLoS Negl Trop Dis, 2015, 9 (2): e0003454. 3.Yang Hong1, Lini Huang1, Jianmei Yang, Xiaodan Cao, Qian Han, Min Zhang, Yanhui Han, Zhiqiang Fu, Chuangang Zhu, Ke Lu, Xiangrui Li, Jiaojiao Lin. Cloning, expression and enzymatic characterization of 3-phosphoglycerate kinase from Schistosoma japonicum. Exp Parasitol, 2015, 159: 37-45. 4.Yang Hong1, Anguo Sun1, Min Zhang, Fei Gao, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jiaojiao Lin. Proteomics analysis of differentially expressed proteins in schistosomula and adult worms of Schistosoma japonicum. Acta Trop, 2013, 126(1): 1-10. 5.Yang Hong, Yanhui Han, Zhiqiang Fu, Hongxiao Han, Chunhui Qiu, Min Zhang, Jianmei Yang, Yaojun Shi, Xiangrui Li, Jiaojiao Lin. Characterization and expression of the Schistosoma japonicum thioredoxin peroxidase-2 gene. J Parasitol, 2013, 99(1): 68-76.  6.Yang Hong, Jinbiao Peng, Weibin Jiang, Zhiqiang Fu, Jinming Liu, Yaojun Shi, Xiangrui Li, Jiaojiao Lin. Proteomic analysis of Schistosoma japonicum schistosomulum proteins that are differentially expressed among hosts differing in their susceptibility to the infection. Molecular & Cellular Proteomics, 2011, 10(8): M110006098 7.Yang Hong, Hongxiao Han, Jinbiao Peng, Ye Li, Yaojun Shi, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin, Xiangrui Li. Schistosoma japonicum: Cloning, expression and characterization of a gene encoding the α5-subunit of the proteasome. Exp Parasitol, 2010, 126(4): 517-525. 8.Xiaodan Cao, Yang Hong, Min Zhang, Yanhui Han, Miaoli Wu, Xinzhuo Wang, Xiaoyong Guo, Changjian Li, Ke Lu, Hao Li, Zhiqiang Fu, Jiaojiao Lin. Cloning, expression and characterization of protein disulfide isomerase of Schistosoma japonicum. Exp Parasitol, 2014, 146C: 43-51. 9.Min Zhang, Yang Hong, Yanhui Han, Hongxiao Han, Jinbiao Peng, Chunhui Qiu, Jianmei Yang, Ke Lu, Zhiqiang Fu, Jiaojiao Lin. Proteomic Analysis of Tegument-Exposed Proteins of Female and Male Schistosoma japonicum Worms. J Proteome Res, 2013, 12 (11): 5260-5270. 10.Jianmei Yang, Yang Hong, Chunxiu Yuan, Zhiqiang Fu, Yaojun Shi, Min Zhang, Liuhong Shen, Yanhui Han, Chuangang Zhu, Hao Li, Ke Lu, Jinming Liu, Xingang Feng, Jiaojiao Lin. Microarray Analysis of Gene Expression Profiles of Schistosoma japonicum Derived from Less-Susceptible Host Water Buffalo and Susceptible Host Goat. PLoS One, 2013, 8 (8): e70367. 11.Chunhui Qiu, Yang Hong, Yan Cao, Fei Wang, Zhiqiang Fu, Yaojun Shi, Meimei Wei, Shengfa Liu, Jiaojiao Lin. Molecular cloning and characterization of glutamine synthetase, a tegumental protein from Schistosoma japonicum. Parasitol Res, 2012, 111(6):2367-2376. 12.Weibin Jiang, Yang Hong, JinbiaoPeng, Zhiqiang Fu, Xingang Feng, Jinming Liu, Yaojun Shi, Jiaojiao Lin . Study on differences in the pathology, T cell subsets and gene expression in susceptible and non-susceptible hosts infected with Schistosoma japonicum, PLoS One, 2010, 5(10): e13494. 13.Jianmei Yang, Zhiqiang Fu, Yang Hong, Haiwei Wu, Yamei Jin, Chuangang Zhu, Hao Li, Ke Lu, Yaojun Shi, Chunxiu Yuan, Guofeng Cheng, Xingang Feng, Jinming Liu, Jiaojiao Lin. The Differential Expression of Immune Genes between Water Buffalo and Yellow Cattle Determines Species-Specific Susceptibility to Schistosoma japonicum Infection. PLoS One, 2015, 10 (6): e0130344. 14.Hongxiao Han, Jinbiao Peng, Yang Hong, Zhiqiang Fu, Ke Lu, Hao Li, Chuangang Zhu, Qiuhua Zhao, Jiaojiao Lin. Comparative characterization of microRNAs in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice. Parasitol Res, 2015, 114 (7): 2639-2647. 15.Yanhui Han, Zhiqiang Fu, Yang Hong, Min Zhang, Hongxiao Han, Ke Lu, Jianmei Yang, Xiangrui Li, Jiaojiao Lin. Inhibitory effects and analysis of RNA interference on thioredoxin glutathione reductase expression in Schistosoma japonicum. J Parasitol, 2014, 100 (4): 463-469. 16.Hongxiao Han, Jinbiao Peng, Yang Hong, Min Zhang, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jinjun Xu, Jianping Tao, Jiaojiao Lin. Comparison of the differential expression miRNAs in Wistar rats before and 10 days after S. japonicum infection. Parasit Vectors, 2013, 6(1): 120. 17.Hongxiao Han, Jinbiao Peng, Yang Hong, Min Zhang, Yanhui Han, Dandan Liu, Zhiqiang Fu, Yaojun Shi, Jinjun Xu, Jianping Tao, Jiaojiao Lin. MicroRNA expression profile in different tissues of BALB/c mice in the early phase of Schistosoma japonicum infection. Mol Biochem Parasitol, 2013, 188(1): 1-9. 18.Yanian Xiong, Min Zhang, Yang Hong, Meimei Wei, Dezhou Ai, Peipei Meng, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jianmei Yang, Jiaojiao Lin. Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin. PLoS One, 2013, 8 (6): e66396. 19.Chunhui Qiu, Shengfa Liu, Yang Hong, Zhiqiang Fu, Meimei Wei, Dezhou Ai, Jiaojiao Lin. Molecular characterization of thyroid hormone receptor beta from Schistosoma japonicum and assessment of its potential as a vaccine candidate antigen against schistosomiasis in BALB/c mice. Parasit Vectors, 2012, 5: 172. 20.Xiujuan Wu, Bin Zhao, Yang Hong, Xuezhen Li, Jinbiao Peng, Juan Zhang, Fei Wang, Yaojun Shi, Zhiqiang Fu, Jiaojiao Lin. Characterization of Schistosoma japonicum estrogen-related receptor beta like 1 and immunogenicity analysis of the recombinant protein. Exp Parasitol, 2012, 131(3): 383-392. 21.Yanhui Han, Min Zhang, Yang Hong, Zhu Zhu, Dong Li, Xiangrui Li, Zhiqiang Fu, Jiaojiao Lin. Characterization of thioredoxin glutathione reductase in Schiotosoma japonicum. Parasitol Int, 2012, 61(3): 475-480. 22.Hongxiao Han, Jinbiao Peng, Yang Hong, Zhiqiang Fu, Jinjun Xu, Jiaojiao Lin, Jianping Tao. Molecular cloning and characterization of a cyclophilin A homologue from Schistosoma japonicum. Parasitol Res, 2012, 111(2): 807-817. 23.Yanian Xiong, Min Zhang, Yang Hong, Meimei Wei, Dezhou Ai, Peipei Meng, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jianmei Yang, Jiaojiao Lin. Characterization Analysis of Schistosoma japonicum Plasma Membrane Repair Relative Gene Myoferlin. PLoS One, 2013, 8 (6): e66396. 24.Jinbiao Peng, Geoffrey N. Gobert, Yang Hong, Weibin Jiang, Hongxiao Han, Donald P. McManus, Xinzhi Wang, Jinming Liu, Zhiqiang Fu, Yaojun Shi, Jiaojiao Lin. Apoptosis Governs the Elimination of Schistosoma japonicum from the Non-Permissive Host Microtus fortis. PLoS One, 2011, 6(6): e21109. 25.Jinbiao Peng, Hongxiao Han, Yang Hong, Zhiqiang Fu, Jinming Liu, Jiaojiao Lin. Molecular cloning and characterization of a gene encoding methionine aminopeptidase 2 of Schistosoma japonicum. Parasitology Research, 2010, 107(4): 939-946. 26.Chunhui Qiu, Zhiqiang Fu, Yaojun Shi, Yang Hong, Shengfa Liu, Jiaojiao Lin. A retinoid X receptor (RXR1) homolog from Schistosoma japonicum: Its ligand-binding domain may bind to 9-cis-retinoic acid. Mol Biochem Parasitol, 2013, 188(1): 40-50. 27.Hongxiao Han, Jinbiao Peng, Geoffrey N Gobert, Yang Hong, Min Zhang, Yanhui Han, Zhiqiang Fu, Yaojun Shi, Jinjun Xu, Jiaojiao Lin, Jianping Tao. Apoptosis phenomenon in the schistosomulum and adult worm lifecycle stages of Schistosoma japonicum. Parasitol Int, 2013, 62(2): 100-108. 28.Jinbiao Peng, Hongxiao Han, Geoffrey N. Gobert, Yang Hong, Weibin Jiang, Xinzhi Wang, Zhiqiang Fu, Jinming Liu, Yaojun Shi, Jiaojiao Lin. Differential gene expression in Schistosoma japonicum schistosomula from Wistar rats and BALB/c mice. Parasit Vectors, 2011, 4(1): 155. 29.Min Zhang, Yanhui Han, Zhu Zhu, Dong Li, Yang Hong, Xiujuan Wu, Zhiqiang Fu, Jiaojiao Lin. Cloning, expression, and characterization of Schistosoma japonicum tegument protein phosphodiesterase-5. Parasitol Res, 2012, 110(2): 775-786. 30.Zhu Zhu, Zhiqiang Fu, Min Zhang, Yanhui Han, Yang Hong, Dong Li, Zhixin Zhao, Yaojun Shi, Xiangrui Li, Jiaojiao Lin. Protective efficacy evaluation induced by recombinant protein LHD-Sj23-GST of Schistosoma japonicum emulsified with three different adjuvants. Parasite Immunol, 2012, 34(6): 341-344. 31.Yanian Xiong, Dezhou Ai, Peipei Meng, Meimei Wei, Yang Hong, Min Zhang, Lini Huang, Zhiqiang Fu, Yaojun Shi, Jiaojiao Lin. Cloning, expression, and preliminary characterization of the dysferlin tegument protein in Schistosoma japonicum. Parasitol Int, 2013, 62 (6): 522-529. 32.Jianmei Yang, Xingang Feng, Zhiqiang Fu, Chunxiu Yuan, Yang Hong, Yaojun Shi, Min Zhang, Jinming Liu, Hao Li, Ke Lu, Jiaojiao Lin. Ultrastructural Observation and Gene Expression Profiling of Schistosoma japonicum Derived from Two Natural Reservoir Hosts, Water Buffalo and Yellow Cattle. PLoS One, 2012, 7(10): e47660. 33.Na Ta, Xingang Feng, Lingling Deng, Zhiqiang Fu, Yang Hong, Jinming Liu, Hao Li, Ke Lu, Jiaojiao Lin, Chunxiu Yuan. Characterization and expression analysis of Wnt5 in Schistosoma japonicum at different developmental stages. Parasitol Res, 2015, 114 (9): 3261-3269. 34.Jianmei Yang, Zhiqiang Fu, Xingang Feng, Yaojun Shi, Chunxiu Yuan, Jinming Liu, Yang Hong, Hao Li, Ke Lu, Jiaojiao Lin. Comparison of worm development and host immune responses in natural hosts of Schistosoma japonicum, yellow cattle and water buffalo. BMC Vet Res, 2012, 8: 25. 35.Yan Cao, Bin Zhao, Yanhui Han, Juan Zhang, Xuezhen Li, Chunhui Qiu, Xiujuan Wu, Yang Hong, Dezhou Ai, Jiaojiao Lin, Zhiqiang Fu. Gene gun bombardment with DNA-coated golden particles enhanced the protective effect of a DNA vaccine based on thioredoxin glutathione reductase of Schistoma japonicum. Biomed Res Int, 2013, 2013: 952416.