李丽薇

一、个人简历

李丽薇，博士，副研究员，硕士生导师，猪病毒性繁殖障碍疫病防控技术研究团队科研助理。

长期从事猪繁殖与呼吸综合症病毒对宿主致病机制、诱导的宿主免疫反应、以及病毒蛋白与宿主之间的相互作用等研究工作。主持国家自然科学基金青年科学基金项目1项，上海市农委科技兴农项目1项，上海市兽医生物技术重点实验室开放课题研究基金1项，中央级公益性科研院所基本科研业务费专项资金项目2项，在《Frontiers in immunology》、《Veterinary Microbiology》、《Virus Research》等国内外学术期刊发表论文20余篇，其中第一或共同第一作者SCI论文13篇，授权专利4项。

二、联系方式

办公电话：021-34293773

邮       箱：liliwei@shvri.ac.cn

三、教育经历

2006.09-2010.06 东北农业大学 动物医学（本硕）专业 学士

2010.09-2015.06 中国农业科学院上海兽医研究所 预防兽医学专业 博士

四、工作经历

2015.07-2018.07 中国农科院上海兽医研究所 博士后

2018.07-2018.12 中国农科院上海兽医研究所 助理研究员

2019.01至今 中国农科院上海兽医研究所 副研究员

五、代表论著

1. Liwei Li^#, Jinxia Chen^#, Zhengda Cao, Yunlei Cao, Ziqiang Guo, Wu Tong, Yanjun Zhou, Guoxin Li, Yifeng Jiang, Changlong Liu, Lingxue Yu, Sina Qiao, Jiachen Liu, Guangzhi Tong^*, Fei Gao^*. Recombinant bivalent live vectored vaccine against CSF and HP-PRRS revealed adequate heterogeneous protection against NADC30-like strain. Frontiers in Microbiology, 2022, 12:822749. doi: 10.3389/fmicb.2021.822749.

2. Xiaona Liu#, Liwei Li#, Fei Gao,Yifeng Jiang, Wanzhe Yuan, Guoxin Li, Lingxue Yu, Yanjun Zhou, Guangzhi Tong, Kuan Zhao*. cGAS Restricts PRRSV Replication by Sensing the mtDNA to Increase the cGAMP Activity. Frontiers in immunology, 2022, 13:887054. doi: 10.3389/fimmu.2022.887054.

3. Zhengda Cao^#, Jinxia Chen^#, Liwei Li^#, Jiachen Liu, Wu Tong, Yanjun Zhou, Guangzhi Tong, Guihua Wang*, Fei Gao*. A rescued NADC30-like virus by reverse genetic manipulation exhibits moderate virulence and a promising application perspective. Virus Research, 2022, 316:198801. doi: 10.1016/j.virusres.2022.198801.

4. Jia Li^#, Yewei Xie^#, Liwei Li^#, Xiaobing Li, Li Shen, Jin Gong, Rufang Zhang*, 2021. MicroRNA-30a Modulates Type I Interferon Responses to Facilitate Coxsackievirus B3 Replication via Targeting Tripartite Motif Protein 25. Frontiers in immunology, 2021, 11:603747. doi: 10.3389/fimmu.2020.603437

5. Yuanzhe Bai^#, Liwei Li^#, Tongling Shan, Xiaoyong Chen, Yujiao Zhang, Fei Gao, Yifeng Jiang, Yanjun Zhou, Guoxin Li, Lingxue Yu, Ning Kong, Zhiyong Ma, Guangzhi Tong*. Proteasomal degradation of nonstructural protein 12 by RNF114 suppresses porcine reproductive and respiratory syndrome virus replication. Veterinary microbiology, 2020, 246, 108746.

6. Liwei Li^#, Kuan Zhao^#, Fei Gao, Yifeng Jiang, Tongling Shan, Wu Tong, Hao Zheng, Lingxue Yu, Guoxin Li, Zhiyong Ma, Guangzhi Tong*. Restriction of porcine reproductive and respiratory syndrome virus replication by galectin-1. Veterinary microbiology, 2019, 235: 310-318.

7. Kuan Zhao^#, Liwei Li^#, Yifeng Jiang, Fei Gao, Yujiao Zhang, Wenying Zhao, Guoxin Li, Lingxue Yu, Yanjun Zhou, Guangzhi Tong*. Nucleocapsid protein of porcine reproductive and respiratory syndrome virus antagonizes the antiviral activity of TRIM25 by interfering with TRIM25-mediated RIG-I ubiquitination. Veterinary microbiology, 2019, 233: 140-146.

8. Liwei Li, Fei Gao, Hao Zheng, Yifeng Jiang, Wu Tong, Yanjun Zhou, Guangzhi Tong*. Utilizing Host Endogenous microRNAs to Negatively Regulate the Replication of Porcine Reproductive and Respiratory Syndrome Virus in MARC-145 cells. PLOS ONE, 2018, 13(7):e0200029. doi: 10.1371/journal.pone.0200029.

9. Liwei Li, Yanjun Zhou, Yifeng Jiang, Fei Gao, Tongling Shan, Kuan Zhao, Yujiao Zhang, Lin Li, Guangzhi Tong*. Galectin-3 inhibits replication of porcine reproductive and respiratory syndrome virus by interacting with viral Nsp12 in vitro. Virus Research, 2018, 253:87-91. doi: 10.1016/j.virusres.2018.06.006.

10. Liwei Li, Fei Gao, Yifeng Jiang, Wu Tong, Hao Zheng, Tongling Shan, Ning Kong, Hai Yu, Deqiang Yang, Kuan Zhao, Yujiao Zhang, Guangzhi Tong*. Development of Monoclonal Antibodies Specifically Recognizing the Non-structural Protein 12 of type 2 Porcine Reproductive and Respiratory Syndrome Virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy, 2018, 37: 2, doi: 10.1089/mab.2017.0060.

六、 专利标准

1、 高飞，张玉娇，童光志，郑浩，李丽薇，虞凌雪，姜一峰，童武，张宽. 【猪CD163蛋白单克隆抗体的制备方法、表位鉴定及应用】. 2020，中国国家知识产权局发明专利，ZL202010629062.4.

2、 高飞，童光志，周艳君，姜一峰，曲泽慧，李丽薇，虞凌雪，郑浩. 【表达海肾或萤火虫荧光素酶基因的PRRSV重组质粒的构建方法及应用】. 2015，中国国家知识产权局发明专利，ZL201510069182.2.

3、 童光志，高飞，姜一峰，李国新，周艳君，虞凌雪，李丽薇，童武，郑浩，杨莘. 【表达猪瘟病毒E2蛋白重组PRRS病毒基因工程疫苗的构建方法和应用】. 2014，中国国家知识产权局发明专利，ZL201410801939.8.

4、 童光志，周艳君，李慧春，张文超，陈鹏飞，李先斌，虞凌雪，姜一峰，高飞，李丽薇. 【猪Delta冠状病毒N蛋白单克隆抗体及其抗原表位和应用】. 2022，中国国家知识产权局发明专利，ZL201711127879.6.