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人才队伍

孙英杰


一、个人简历

孙英杰,1985年12月生,江苏省丹阳人,博士,研究员,博士生导师,现任禽病研究室副主任、上海兽医研究所团委书记,国家优秀青年科学基金获得者,入选中国农业科学院青年英才、领军人才(B类)计划,上海领军人才“后备队”。担任国际期刊CIMID编委,病毒学报编委,中国畜牧兽医学会动物传染病学分会青年学者专业组委员。

长期从事新城疫病毒和其他家禽重要病毒分子致病机制方向的研究。筛选家禽重要病毒感染宿主关键因子及抗病毒靶点,探明宿主代谢与免疫在家禽重要病毒感染中的作用,探索新型广谱抗病毒策略,为禽病防控和高效细胞疫苗的制备提供理论支撑。主持国家和省部级项目7项。以第一或通讯作者在《mBio》、《Plos Pathogens》、《iScience》、《Journal of Virology》、《FASEB Journal》等国内外发表论文25篇,其中SCI论文15篇,获专利4件。

二、联系方式

办公电话:021-34293426

邮   箱:sunyingjie@shvri.ac.cn

三、教育经历

2003.09-2007.06  扬州大学    动物医学      学士

2007.09-2010.06  中国农业科学院研究生院  预防兽医学    硕士

2010.09-2013.06  中国农业科学院研究生院  预防兽医学    博士

四、工作经历

2013.07-2016.12 中国农科院上海兽医研究所 助理研究员

2016.07-2020.12 中国农科院上海兽医研究所 副研究员

2021.01至今 中国农科院上海兽医研究所 研究员

2020.12-2022.03 中国农科院上海兽医研究所 科研管理处副处长

2022.03至今 中国农科院上海兽医研究所 禽病研究室副主任

五、代表论著

[1] Wei Wu, Yang Qu, Shengqing Yu, Sa Wang, Yuncong Yin, Qinfang Liu, Chunchun Meng, Ying Liao, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Weiwei Liu, Chan Ding*, Yingjie Sun*, Caspase-Dependent Cleavage of DDX21 Suppresses Host Innate Immunity, mBio, 2021

[2] Shanhui Ren, Zaib Ur Rehman, Bo Gao, Zengqi Yang, Jiyong Zhou, Chunchun Meng, Cuiping Song, Venugopal Nair, Yingjie Sun*, Chan Ding*, ATM-mediated DNA double-strand break response facilitated oncolytic Newcastle disease virus replication and promoted syncytium formation in tumor cells, Plos Pathogens, 2020, 16(6):e1008514.

[3] Yuan Zhan, Shengqing Yu, Shen Yang, Xusheng Qiu, Chunchun Meng, Lei Tan, Cuiping Song, Ying Liao, Weiwei Liu, Yingjie Sun*, Chan Ding*, Newcastle Disease virus infection activates PI3K/Akt/mTOR and p38 MAPK/Mnk1 pathways to benefit viral mRNA translation via interaction of the viral NP protein and host eIF4E, Plos Pathogens, 2020, 16(6):e1008610.

[4] Xianjin Kan, Yuncong Yin, Cuiping Song, Lei Tan, Xusheng Qiu, Ying Liao, Weiwei Liu, Songshu Meng, Yingjie Sun,* and Chan Ding*, Newcastle-disease-virus-induced ferroptosis through nutrient deprivation and ferritinophagy in tumor cells, iScience, 2021, 24(8): 102837.

[5] Yingjie Sun†, Hang Zheng†, Shengqing Yu, Yunlei Ding, Wei Wu, Xuming Mao, Ying Liao, Chunchun Meng, Zaib Ur Rehman, Lei Tan, Cuiping Song, Xusheng Qiu, Fengyun Wu, and Chan Ding*, Newcastle disease virus V protein degrades mitochondrial antiviral-signaling protein to inhibit host type I interferon production via E3 ubiquitin ligase RNF5, Journal of Virology, 2019;93(18):e00322-19

[6] Yingjie Sun, Luna Dong, Shengqing Yu, Xiaoxu Wang, Hang Zheng, Pin Zhang, Chunchun Meng, Yuan Zhan, Lei Tan, Cuiping Song, Xusheng Qiu, Guijun Wang, Ying Liao, and Chan Ding*, Newcastle disease virus induces stable formation of bona fide stress granules to facilitate viral replication through manipulating host protein translation, FASEB Journal, 2017, 31 (4)

[7] Yingjie Sun, Shengqing Yu, Na Ding, Chunchun Meng, Songshu Meng, Shilei Zhang, Yuan Zhan, Xusheng Qiu, Lei Tan, Hongjun Chen, Cuiping Song, Chan Ding*. Autophagy Benefits the Replication of Newcastle Disease Virus in Chicken Cells and Tissues. Journal of Virology, 2014, 88(1): 525-537.

[8] Shanhui Ren, Chan Ding* Yingjie Sun*, Morphology Remodeling and Selective Autophagy of Intracellular Organelles during Viral Infections, International Journal of Molecular Sciences, 2020, 21(10): 3689.

[9] Hui Jiang, Xianjin Kan, Chan Ding* Yingjie Sun*, The multi-faceted role of autophagy during animal virus infection. Frontiers Cellular and Infection Microbiology, 2022.

[10]  Yingjie Sun, Na Ding, Siyu Serena Ding, Shengqing Yu, Chunhun Meng, Hongjun Chen, Xusheng Qiu, Shilei Zhang, Yang Yu, Yuan Zhan, Chan Ding*. Goose RIG-I functions in innate immunity against Newcastle disease virus infection, Molecular Immunology 53.4(2013):321-327.

六、专利标准

[1] Chan Ding, Huabin Shao, Lei Tan, Guoyuan Wen, Shengqing Yu, Xusheng Qiu, Ying Liao, Chunchun Meng, Yingjie Sun, Cuiping Song, A COMPOSITE MULTI-EPITOPE EXPRESSION CASSETTE, A RECOMBINANT VIRUS COMPOSED THEREOF AND APPLICATION THEREOF, 授权时间:2022.04.19,美国专利号:US 11,305,007,B2

[2] 丁铲,邵华斌,谭磊,温国元,于圣青,仇旭升,廖瑛,孟春春,孙英杰,宋翠萍,一种复合多表位表达盒、其组成的重组病毒及应用。授权时间:2022.06.10,中国专利号:ZL201810394542.

[3] 丁铲,孙英杰,仇旭升,谭磊,宋翠萍,一种具有抗新城疫病毒活性的鹅源基因RIG-I及应用,2015-12-22,中国,ZL201210281895.1

[4] 丁铲,孙英杰,谭磊,孟春春,仇旭升,廖瑛,宋翠萍;于圣青,郑航,一种鹅源线粒体抗病毒信号蛋白及其应用,2021-08-03,中国,ZL201810367202.8

[5] 丁铲,谭磊,仇旭升,宋翠萍,孙英杰,于圣青,范瑾,鸡IBV S1蛋白的CD8+ T细胞抗原表位多肽,2015-04-15,中国,201310317878.3

[6] 于圣青,田明星,丁铲,韩先干,王少辉,孙英杰,翟晶,鲍衍清,高建鹏,pTM系列质粒载体其构建方法以及在布鲁菌表达外源基因中的应用,2019-01-11,中国,ZL201510690461.0