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人才队伍

魏建超


研究方向:虫媒人畜共患病毒病及兽医公共卫生学

电话:021-34510616

邮箱:jianchaowei@shvri.ac.cn

 

 

1、个人简历

魏建超,男,博士,副研究员,硕士导师,中国农业科学院上海兽医研究所猪呼吸道传染病创新团队骨干专家20107月至今,在中国农业科学院上海兽医研究所猪呼吸道传染病创新团队工作,从事虫媒和动物虫媒病毒的基础和应用研究,特别是流行性乙型脑炎病毒、非洲猪瘟病毒的致病机制、新型诊断技术和疫苗的研究近年来,先后主持国家自然科学基金、“973”计划子课题、上海市自然基金面上项目,上海市农业领域重点项目等国家、省部级科研课题15发表学术论文90多篇,其中第一作者或通讯作者PLoS PathogTransbound Emerg DisFront MicrobiolAntiviral Research等杂志上发表SCI论文20其中JCR1篇,JCR二区13)。主编、参编《动物解剖生理》《动物防疫与检疫技术》等教材3部。申请专利17项目,已获得授权专利13项。

 

2、教育经历

1999.09-2003.06  湖北农学院       畜牧兽医专业     学士

2003.09-2006.06  南京农业大学      预防兽医学专业    硕士

   2007.09-2010.06 南京农业大学      预防兽医学专业   博士

 

3、工作经历

时间              单位        职务/职称                   

2010.07-2016.12    中国农业科学院上海兽医研究所   助理研究员

2017.01至今       中国农业科学院上海兽医研究所     副研究员

 

4、主持项目和承担课题

主持项目(11项,总经费547.08万元)

  • 国家自然科学基金委员会,应急项目,31941012,非洲猪瘟病毒流行特征、毒株的遗传演化、溯源与早诊检技术,2020-012022-1230万元,子任务负责人;
  • 上海市科学技术委员会,农业领域项目,20392002400,便携式恒温基因扩增仪及其配套的非洲猪瘟现场快速检测试剂的研制,2020-062023-1070万;
  • 上海市农业委员会,科技兴农技术创新项目,2021-02-08-00-12-F00770养殖场专用蚊蝇驱避剂的研究与应用示范2021-52024-499.68万;
  • 上海市科学技术委员会,自然基金面上项目,19ZR1469000p53调控ZDHHC1抗乙型脑炎病毒机制的研究,2019-072022-0620万;
  • 中国农业科学院基本科研业务费专项院级统筹项目,Y2020PT40,重组乙型脑炎病毒技术研究,2020 -012021 -1283万元;
  • 中国农业科学院基本科研业务费专项院级统筹项目,Y2020YJ15抗非洲猪瘟病毒新型基因工程疫苗创制2021-12021-1240万元,子任务负责人;
  • 横向课题:上海罗克环控节能科技股份有限公司,消毒屋、防疫卫士、抑菌湿帘、消毒除臭剂等畜牧业用防疫、环保产品的开发,2020-102022-1015万元;
  • 横向课题:广西壮族自治区中医药研究院--壮瑶药挥发油抗病毒筛选及效果鉴定,负责抗流感病毒药物的筛选及效果评价,2020-012021-1215万元;
  • 横向课题:创澳(上海)环保科技发展有限公司-- APEX澳飘克斯®植物精油除臭剂对蚊蝇的驱避效果,2020-012021-125万元;
  • 科学技术部,国家重点基础研究发展计划(973计划)课题,2014CB542703-2PRRSVPCV2等病原共感染在调控炎症反应及致病性中的作用,2014-012018-1286.4万元;(已结题
  • 国家自然科学基金委员会,青年基金,31302116,整合素β3在日本脑炎病毒进入血管内皮细胞过程中的作用研究,2014-012016-1220万元;(已结题
  • 中央级公益性科研院所基本科研业务费专项资金项目,2019JB10JEV感染猪/小鼠引发睾丸炎的分子机制,2019-012021-1212;(已结题
  • 中央级公益性科研院所基本科研业务费专项资金项目,2017JB10,基因型与基因JEV毒株间交叉保护作用研究,2017-012018-1215万元;(已结题
  • 中央级公益性科研院所基本科研业务费2013JB08展示日本脑炎病毒B细胞表位和T细胞表位的猪细小病毒颗粒样疫苗的研制2013-012014-1218万;(已结题
  • 中央级公益性科研院所基本科研业务费2011JB06,泛素蛋白酶体通路在猪流感病毒感染中作用的解析,2011-012012-1218万;(已结题

 

作为项目骨干参与项目(5项):

  • 科学技术部,国家重点研发计划项目政府间国际科技创新合作重点专项,2018YFE0101300,新型高效安全的猪链球菌BoHV-4 活载体疫苗研究,2019-012021-12495万元,在研,项目骨干,负责BoHV-4 活载体疫苗在猪体上免疫原性评价;
  • 上海市科学技术委员会,农业重点科技攻关项目,17391901600,乙型脑炎病毒基因I型弱毒苗研究,2017-122021-1280万元,在研,项目骨干,负责乙型脑炎病毒基因I型弱毒苗研制与新兽药证书申报;
  • 中国农业科学院基本科研业务费专项院级统筹项目,Y2019YJ07-02,非洲猪瘟联合攻关-诊断与检测技术与产品研发,2019-112020-12100万元,项目骨干,负责非洲猪瘟现场快速检测试剂及其便携式恒温基因扩增仪的研制;
  • 科学技术部,国家国际科技合作专项,2014DEF30140,乙脑病毒优势型别变化的生态流行病学及风险,2014-112017-12127万元,已结题,项目骨干,负责乙脑病毒生态流行病学调查与风险评估。
  • 上海市农业农村委员会,科技兴农重点攻关项目,沪农科攻字(2013)第5-6号,红斑疹病病原学及防控技术研究2014-12016-12100万元,已结题,项目骨干,负责猪红斑疹病流行病学调查与防控技术研究

 

5、代表论文与著作

  • Chenxi Li, Di Di, Hui Huang, Xin Wang, Qiqi Xia, Xiaochun Ma, Ke Liu, Beibei Li,Donghua Shao, Yafeng Qiu, Zongjie Li, Jianchao Wei*, Zhiyong Ma*. NS5-V372A and NS5-H386Y variations are responsible for differences in interferon α/β induction and co-contribute to the replication advantage of Japanese encephalitis virus genotype I over genotype III in ducklings[J].PLoS Pathog,2020,16(9): e1008773.JCR区,IF=6.218
  • Deng Xufang#, Wei Jianchao#, Shi Zixue, Yan Wenjun, Wu Zhuanchang, Shao Donghua, Li Beibei, Liu Ke, Wang Xiaodu, Qiu Yafeng, Ma Zhiyong*.Tumor suppressor p53 functions as an essential antiviral molecule against Japanese encephalitis virus[J].J Genet Genomics. 2016, 43(12):709-712. doi: 10.1016/j.jgg.2016.07.002. JCR区,IF=5.065
  • Jianchao Wei#, Muddassar Hameed#, Xin Wang#, Junjie Zhang, Shuang Guo, Muhammad Naveed Anwar, Linlin Pang, Ke Liu, Beibei Li, Donghua Shao , Yafeng Qiu , Dengke Zhong*, Bin Zhou*, Zhiyong Ma*.Antiviral activity of phage display-selected peptides against Japanese encephalitis virus infection in vitro and in vivo[J].Antiviral Research,2020,174:104673. JCR二区,IF=4.13
  • Jianchao Wei, Xin Wang, Junjie Zhang, Shuang Guo, Linlin Pang, Kun Shi, Ke Liu,Donghua Shao, Yafeng Qiu, Lihong Liu, Frederik Wide′n, Beibei Li*, Zhiyong Ma*.Partial cross-protection between Japanese encephalitis virus genotype I and III in mice[J].PLoS Negl Trop Dis,2019,13(8):e0007601. JCR二区,IF=4.487
  • Muddassar Hameed,Ke Liu,Muhammad Naveed Anwar,Abdul Wahaab,Chenxi Li, Di Di,Xin Wang,Sawar Khan,Jinpeng Xu,Beibei Li,Mohsin Nawaz,Donghua Shao,Yafeng Qiu,Jianchao Wei*,Zhiyong Ma*.A viral metagenomic analysis reveals rich viral abundance and diversity in mosquitoes from pig farms[J]. Transbound Emerg Dis,2020,00:1-16. doi: 10.1111/tbed.13355. JCR二区,IF=4.188
  • Muddassar Hameed,Sawar Khan,Jinpeng Xu,Junjie Zhang,Xin Wang,Di Di,Zheng Chen,Muhammad Naveed Anwar,Abdul Wahaab,Xiaochun Ma,Mohsin Nawaz,Ke Liu,Beibei Li,Donghua Shao,Yafeng Qiu,Jianchao Wei*,Zhiyong Ma*.Detection of Japanese Encephalitis Virus in Mosquitoes from Xinjiang during Next Generation Sequencing Arboviral Surveillance[J]. Transbound Emerg Dis. 2020 Jul 2. doi: 10.1111/tbed.13697. JCR二区,IF=4.188
  • Muddassar Hameed, Ke Liu, Muhammad Naveed Anwar, Abdul Wahaab,Anum Safdar, Di Di, Prerona Boruah, Jinpeng Xu, Xin Wang, Beibei Li, Huaimin Zhu,Mohsin Nawaz, Donghua Shao, Yafeng Qiu, Jianchao Wei*, Zhiyong Ma*.The emerged genotype I of Japanese encephalitis virus shows an infectivity similar to genotype III in Culex pipiens mosquitoes from China. PLoS Negl Trop Dis,2019, 13(9):e0007716. JCR二区,IF=4.487
  • Changguang Xiao, Xin Wang, Guanghui Cui, Linlin Pang, Jinpeng Xu, Chenxi Li,  Junjie Zhang, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Wei Jianchao*, Ma Zhiyong*,Possible pathogenicity of Japanese encephalitis virus in newly hatched domestic ducklings[J].Vet Microbiol. 2018,227:8-11. doi: 10.1016/j.vetmic.2018.10.016. JCR二区,IF=2.791
  • Changguang Xiao, Chenxi Li, Di Di, Julien Cappelle, Lihong Liu, Xin Wang, Linlin Pang, Jinpeng Xu, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Weijie Ren, Frederik Wide´n, Ve´ronique Chevalier, Jianchao Wei*, Xiaodong Wu*, Zhiyong Ma*,Differential replication efficiencies between Japanese encephalitis virus genotype I and III in avian cultured cells and young domestic ducklings[J].PLoS Negl Trop Dis. 2018,12(12):e0007046. JCR二区,IF=4.487
  • Muddassar Hameed†, Abdul Wahaab†, Tongling Shan†, Xin Wang, Sawar Khan, Di Di,Liu Xiqian, Jun-Jie Zhang, Muhammad Naveed Anwar, Mohsin Nawaz, Beibei Li, Ke Liu,Donghua Shao, Yafeng Qiu, Jianchao Wei* and Zhiyong Ma*. A Metagenomic Analysis of Mosquito Virome Collected From Different Animal Farms at Yunnan-Myanmar Border of China[J]. .Front Microbiol. 2021 Feb 8;11:591478. JCR二区,IF=4.235
  • Muhammad Naveed Anwar, Xin Wang, Muddassar Hameed, Abdul Wahaab, Chenxi Li ,Mona Sharma, Linlin Pang, Muhammad Irfan Malik, Ke Liu, Beibei Li, Yafeng Qiu,Jianchao Wei*, Zhiyong Ma*.Phenotypic and Genotypic Comparison of a Live-Attenuated Genotype I Japanese Encephalitis Virus SD12-F120 Strain with Its Virulent Parental SD12 Strain[J].Viruses 2020, 12, 552; doi:10.3390/v12050552. JCR二区,IF=3.811
  • Di Di, Chenxi Li, Junjie Zhang, Muddassar Hameed , Xin Wang, Qiqi Xia, Hui Li, Shumin Xi,Zongjie Li, Ke Liu, Beibei Li, Donghua Shao, Yafeng Qiu, Jianchao Wei*,Zhiyong Ma*. Experimental Infection of Newly Hatched Domestic Ducklings via Japanese Encephalitis Virus-Infected Mosquitoes[J].Pathogens, 2020, 9, 371; doi:10.3390/pathogens9050371. JCR三区,IF=3.405
  • Xin Wang, Shuang Guo, Muddassar Hameed, Junjie Zhang, Linlin Pang, Beibei Li,Yafeng Qiu, Ke Liu, Donghua Shao, Zhiyong Ma, Dengke Zhong*, Jianchao Wei*,Peng Li*. Rapid differential detection of genotype I and III Japanese encephalitis virus from clinical samples by a novel duplex TaqMan probe-based RT-qPCR assay[J].Journal of Virological Methods, 2020,279,113841JCR四区,IF=1.746
  • Zongjie Li#, Jianchao Wei#, Di Di, Xin Wang, Chenxi Li, Beibei Li,Yafeng Qiu, Ke Liu, Feng Gu, Minglong Tong, Shuiming Wang,Xiaodong Wu*,Zhiyong Ma*,Rapid and accurate detection of African swine fever virus by DNA endonuclease-targeted CRISPR trans reporter assay.Acta Biochim Biophys Sin (Shanghai). 2020 Dec 29;52(12):1413-1419.  JCR区,IF=2.836
  • Muhammad Naveed Anwar, Shuang Guo, Wang Xin, Muddassar Hameed, Abdul Wahaab, Xiaochun Ma, Aman Ullah Khan, Sajid Ur Rahman, Donghua Shao, Zongjie Li, Ke Liu, Beibei Li, Yafeng Qiu, Zhiyong Ma*, Jianchao Wei*.Adaptation of a live-attenuated genotype I Japanese encephalitis virus to vero cells is associated with mutations in structural protein genes.Virus Res. 2021 Jan 15;292:198256. JCR区,IF=2.934
  • Muddassar Hameed*, Abdul Wahaab, Mohsin Nawaz, Sawar Khan, Jawad Nazir, Ke Liu, Jianchao Wei*,Zhiyong Ma *.Potential Role of Birds in Japanese Encephalitis Virus Zoonotic Transmission and Genotype Shift.Viruses. 2021 Feb 24;13(3):357. JCR二区,IF=3.811
  • Di Di, Li Chen-xi, Li Zong-jie, Wang Xin, Xia Qi-qi, Mona SHARMA, Li Bei-bei, Liu Ke, Shao Dong-hua, Qiu Ya-feng, Soe-Soe WAI, Yang Shi-biao, Wei Jian-chao*, Ma Zhi-yong*. Detection of arboviruses in Culicoides (Diptera: Ceratopogonidae) collected from animal farms in the border areas of Yunnan Province,Chin.Journal of Integrative Agriculture,2021, 20(0): 2–12. JCR二区,IF=2.848.
  • Yan Wenju#, Wei Jianchao#, Deng Xufang, Shi Zixue, Zhu Zixiang, Shao Donghua, Li Beibei, Wang Shaohui, Tong Guangzhi, Ma Zhiyong.Transcriptional analysis of immune-related gene expression in p53-deficient mice with increased susceptibility to influenza A virus infection[J].BMC Med Genomics. 2015,8:52. JCR区,IF=1.746
  • Zixue Shi#, Jianchao Wei#, Xufang Deng, Shuqing Li, Yafeng Qiu, Donghua Shao, Beibei Li, Keyu Zhang,Feiqun Xue, Xiaodu Wang,Zhiyong Ma. Nitazoxanide inhibits the replication of Japanese encephalitis virus in cultured cells and in a mouse model[J].Virol J. 2014,11:10. JCR区,IF=2.503
  • Jianchao Wei#;Yizhu Huang#;Dengke Zhong#;Le Kang;Hassan Ishag;Xiang Mao;Ruibing Cao;Bin Zhou;Puyan Chen*, Design and evaluation of a multi-epitope peptide against Japanese encephalitis virus infection in BALB/c mice,Biochem Biophys Res Commun,2010,396(4): 787-92. JCR三区IF=2.75
  • 钟登科、魏建超 主编, 动物解剖生理,中国农业出版社,ISBN97871092173482017-02-01 1.
  • 魏建超 参编,动物防疫与检疫技术,中国农业出版社,ISBN978710921745420171 1.

 

6、专利和标准

魏建超,马志永,史子学,邵东华,李蓓蓓,晏文君,朱紫祥,抑制流感病毒相关基因的siRNA及其应用,2018.8.31,中国,ZL201610139670.0

马志永,魏建超,史子学,邵东华,李蓓蓓,晏文君,朱紫祥,一种重组载体及其在制备或筛选抗流感药物中的应用,2019.4.2,中国,ZL201610139667.9

马志永,魏建超,史子学,邵东华,李蓓蓓,晏文君,朱紫祥,一种重组载体及其在制备或筛选抗流感药物中的应用,2019.4.2,中国,ZL201610141142.9

马志永,魏建超,史子学,薛飞群,李蓓蓓,一类抗乙型脑炎病毒感染的组合物及其应用,2018.10.23,中国,ZL201510391532.7

马志永,史子学,魏建超,邵东华,王少辉,李蓓蓓,刘阳,一步法检测Z/S亚型埃博拉病毒的实时荧光定量PCR方法及其试剂盒,2017.3.22,中国,ZL201110312855.4

马志永,史子学,魏建超,邵东华,王少辉,李蓓蓓,刘阳,王宗尧,一种检测埃博拉病毒的荧光定量PCR检测方法及其引物和试剂盒,2016.06.08,中国,ZL201110312915.2

马志永,史子学,魏建超,邵东华,王少辉,李蓓蓓,晏文君,朱紫祥,抑制流感病毒相关基因的siRNA及其应用,2018.2.13,中国,ZL201210019712.9

马志永,史子学,魏建超,邵东华,王少辉,李蓓蓓,晏文君,朱紫祥,抑制流感病毒复制的宿主相关基因及其筛选方法和应用,2018.4.6,中国,ZL201210019736.4

马志永,史子学,魏建超,邵东华,薛飞群,王少辉,李蓓蓓,一类抗乙型脑炎病毒感染的组合物及其应用,2015.9.16,中国,ZL201110329906.4