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人才队伍

廖瑛


研究领域:动物病毒学
电话/传真:021-34680291/021-54081818
电子邮件:liaoying@shvri.ac.cn
更多信息:比如实验室主页等

简历(200-500字):
廖瑛,女,2007年获得新加坡南洋理工大学生物学博士学位,先后在新加坡科技局和南洋理工大学工作。2013年12月被中国农业科学院引进为青年英才,现任中国农业科学院上海兽医研究所研究员,中国农业科学院博士研究生导师。主要从事新城疫病毒和猪禽冠状病毒的研究,研究领域包括RNA病毒的入侵和释放、内质网压力应激、蛋白翻译调控、细胞凋亡、天然免疫应答的启动机制、病毒逃逸天然免疫反应的机理等。目前主持科技部重点研发计划课题和国家自然科学基金面上项目,承担中国农业科学院水禽病毒病创新团队课题任务。在国外核心期刊发表研究论文20多篇,影响因子均为3分以上,为Sci收录。


承担科研项目情况:
1.国家自然科学基金面上项目,31772724,应激颗粒作为抗病毒天然免疫信号枢纽的研究,58万元,2018.01-2021.12,在研,主持。
2.科技部重点研发计划,2017YFD0500802, 鹅和番鸭重要疫苗及免疫增强剂研究和应用,483万元,2017.07-2020.12,在研,主持。
3.国家自然科学基金重点项目,31530074,新城疫病毒劫持宿主细胞蛋白翻译系统的机制研究,2016.01-2020.12,283万,在研,参与。
4.中央公益性科研院所基本科研业务费专项资金项目“传染性支气管炎病毒限制干扰素反应的分子机制研究”,2018.1-2020.12,30万,在研。
5.中国农业科学院“青年英才计划”资助项目:300万,2015.01-2018.12,结题,主持。
6.上海市自然科学基金,15ZR1449600,鸡新城疫病毒诱导细胞产生的内质网压力应激,2015/01-2017/12,10万元,结题,主持。
7.中央公益性科研院所基本科研业务费专项资金项目“传染性支气管炎病毒的入胞方式和脱壳位点的研究”,2017.1-2017.12,15万,结题。
8.留学人员科技活动项目择优资助“鸡新城疫病毒与宿主细胞内质网压力应激关系的研究”(2016.1-2016.12),3万,结题。

代表论著:
1.Wang H, Yuan X, Sun Y, Mao X, Meng C, Tan L, Song C, Qiu X, Ding C, Liao Y *. Infectious bronchitis virus entry mainly depends on clathrin mediated endocytosis and requires classical endosomal/lysosomal system. Virology. 2019; 528:118-136. (责任作者)
2.Fan XX#, Han SC#, Yan D, Gao Y, Wei YQ, Liu XT, Liao Y*, Guo HC*, Sun SQ*. Foot-and–mouth disease virus infection suppresses autophagy and NF-кB antiviral responses via degradation of ATG5-ATG12 by 3Cpro 2017. Cell Death & Disease. (#First authors, *Corresponding authors)(责任作者)
3.Liao Y#*, Wang HX#, Mao X, Fang H, Wang H, Li Y, Sun Y, Meng C, Tan L, Song C, Qiu X, Ding C*. RIP1 is a central signaling protein in regulation of TNF-α/TRAIL mediated apoptosis and necroptosis during Newcastle disease virus infection. Oncotarget. 2017. 8 (26): 43201-43217. (第一作者,责任作者)
4.Wang X, Wang R, Luo M, Li C, Wang HX, Huan CC, Qu YR, Liao Y*, Mao X*.  (DEAD)-box RNA helicase 3 modulates NF-κB signal pathway by controlling the phosphorylation of PP2A-C subunit. Oncotarget. 2017 May16;8(20):33197-33213. (*Corresponding authors) (通讯作者)
5.Liao Y#*, Gu F#, Mao X, Niu Q, Wang H, Sun Y, Song C, Qiu X, Tan L, Ding C*. 2016. Regulation of de novo Translation of Host Cells by Manipulation of PERK/PKR and GADD34-PP1 Activity during Newcastle Disease Virus Infection. J Gen Virol. 2016 Apr;97(4):867-79. doi: 10.1099/jgv.0.000426. (第一作者,责任作者)
6.Fung TS, Liao Y*, Liu DX*. Regulation of Stress Responses and Translational Control by Coronavirus. Viruses. 2016 Jul 4;8(7). pii: E184. doi: 10.3390/v8070184. (*Corresponding authors) (影响因子:3.04) (通讯作者)
7.Liao Y, Zhang SM, Neo TL, Tam JP. Tryptophan-dependent membrane interaction and heteromerization with the internal fusion peptide by the membrane proximal external region of SARS-CoV spike protein. Biochemistry. 2015. 54(9):1819-30.
8.Liao Y, Fung TS, Huang M, Fang SG, Zhong YX, Liu DX.RNA Isolation and Northern Blot Analysis. Bio-protocol. 2014. Vol 4, Iss 6
9.Liao Y, Fung TS, Huang M, Fang SG, Zhong Y, Liu DX. Up-regulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway. J Virol. 2013. 87(14):8124-34. May 15.
10.Liao Y, Wang X, Huang M, Tam JP, Liu DX. Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus. Virology. 2011. 420 (2):106-16.
11.Wang, X.X.#, Liao,Y.#, Yap PL, Png KJ, Tam JP, Liu DX. Inhibition of protein kinase R activation and upregulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells. J Virol. 2009. 83(23):12462-72. (#Co-first author)
12.Liao, Y, Yuan, Q, Torres, J, Tam, J. P, and Liu, D. X. Biochemical and functional characterization of the membrane association and membrane permeabilizing activity of the severe acute respiratory syndrome coronavirus envelope protein. Virology. 2006. 349:264-275.
13.Liao, Y., Lescar, J., Tam, P. J., and Liu, D. X. Expression of SARS-coronavirus envelope protein in Escherichia coli cells alters membrane permeability. BBRC. 325: 374-380.
14.Liao, Y., Tam, J. P., and Liu, D. X. 2005. Viroporin activity of SARS-CoV E protein. 2004. Adv. Exp. Med. Biol.199-202.
15.Fung TS, Liao Y, Liu DX. The endoplasmic reticulum stress sensor IRE1α protects cells from apoptosis induced by the coronavirus infectious bronchitis virus. J Virol. 2014 Nov; 88(21):12752-64.
16.Tan L, Liao Y, Fan J, Zhang Y, Mao X, Sun Y, Song C, Qiu X, Meng C, Ding C. Prediction and identification of novel IBV S1 protein derived CTL epitopes in chicken. Vaccine. 2016 Jan 12;34 (3):380-6.
17.Song C, Liao Y, Gao W, Yu S, Sun Y, Qiu X, Tan L, Cheng A, Wang M, Ma Z, Ding C. Virulent and attenuated strains of duck hepatitis A virus elicit discordant innate immune responses in vivo. J Gen Virol. 2014 Dec; 95 (Pt 12):2716-26.
18.Zhong Y, Liao Y, Fang S, Tam JP, Liu DX. 2012. Up-regulation of Mcl-1 and Bak by coronavirus infection of human, avian and animal cells modulates apoptosis and viral replication. PLoS One. 7(1):e30191.
19.Liu, D. X., Yuan, Q., and Liao, Y. 2007. Coronavirus envelope protein: A small membrane protein with multiple functions. Cell Mol Life Sci. 64(16):2043-2048. Review.
20.Yuan, Q., Liao, Y., Torres, J., Tam, J. P., and Liu, D. X. 2006. Biochemical evidence for the presence of mixed membrane topologies of the severe acute respiratory syndrome coronavirus envelope protein expressed in mammalian cells. FEBS. Letter. 580(13): 3192-3200.
21.Wang, X. X., Liao, Y., Wong, S. M., and Liu, D. X. 2005. Identification and characterization of a unique ribosomal frameshifting signal in SARS-CoV ORF 3a. Adv. Exp. Med. Biol. 89-92.